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AboutPricing
Drug ReportsPhytonadione
Phytonadione
M.v.i, Phytonadione, Vitamin K1, Vitaped (phytonadione) is a small molecule pharmaceutical. Phytonadione was first approved as Mephyton on 1982-01-01.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Phytonadione, Vitamin k1 (discontinued: Aquamephyton, Konakion, Mephyton, Phytonadione, Vitamin k1)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phytonadione
Tradename
Company
Number
Date
Products
MEPHYTONBausch Health CompaniesN-010104 DISCN1982-01-01
1 products, RLD
AQUAMEPHYTONPAI PharmaN-012223 DISCN1982-01-01
2 products, RLD
KONAKIONRocheN-011745 DISCN1982-01-01
2 products
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Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
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Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
adult infuvite multiple vitaminsNew Drug Application2025-08-18
mephytonNew Drug Application2020-11-17
pediatric infuvite multiple vitaminsNew Drug Application2025-08-18
phytonadioneANDA2025-09-11
vitalipid nunapproved drug for use in drug shortage2023-09-07
vitamin k1ANDA2024-12-06
vitamin k1 - phytonadioneANDA2024-01-30
vitamin k1 phytonadioneANDA2024-01-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypercholesterolemia—D006937—
hypophosphatemiaHP_0002148D017674—
hypertriglyceridemiaEFO_0004211D015228—
peripheral vascular diseasesEFO_0003875D016491I73.9
dermatitis—D003872L30.9
alcoholic neuropathyEFO_1000803D020269G62.1
common coldEFO_0007214D003139J00
seizures—D012640G40.4
vitamin a deficiencyEFO_1001237D014802E50
hypoparathyroidism—D007011E20
Show 18 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
Code
Description
J3430
Injection, phytonadione (vitamin k), per 1 mg
Clinical
Clinical Trials
470 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MelanomaD008545——1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.0————11
Liver cirrhosisD008103EFO_0001422K74.0————11
FibrosisD005355——————11
Hepatocellular carcinomaD006528—C22.0————11
Liver neoplasmsD008113EFO_1001513C22.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePhytonadione
INNphytomenadione
Description
Phylloquinone is a member of the class of phylloquinones that consists of 1,4-naphthoquinone having methyl and phytyl groups at positions 2 and 3 respectively. The parent of the class of phylloquinones. It has a role as a cofactor, a plant metabolite and a human metabolite. It is a vitamin K and a member of phylloquinones.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CC1=C(C/C=C(\C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=O)c2ccccc2C1=O
Identifiers
PDB—
CAS-ID84-80-0
RxCUI—
ChEMBL IDCHEMBL1550
ChEBI ID18067
PubChem CID5284607
DrugBankDB01022
UNII IDS5Z3U87QHF (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Phytonadione – Amphastar Pharmaceuticals
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Estimated US medical usage
Phytonadione
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,362 documents
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Safety
Black-box Warning
Black-box warning for: Phytonadione, Vitamin k1, Vitamin k1 - phytonadione, Vitamin k1 phytonadione
Adverse Events
Top Adverse Reactions
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1,902 adverse events reported
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