Phentermine
Adipex-p, Ionamin, Lomaira, Phentermine, Qsymia (phentermine) is a small molecule pharmaceutical. Phentermine was first approved as Fastin on 1982-01-01. It is used to treat obesity in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Adipex-p, Phentermine (discontinued: Adipex-p, Fastin, Ionamin, Obestin, Oby-trim, Phentermine, Phentermine resin complex, Suprenza, Tora, Wilpo)
CombinationsPhentermine topiramate, Qsymia
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phentermine hydrochloride
Phentermine hydrochloride
+
Topiramate
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adipex-p | ANDA | 2024-09-03 |
| lomaira | ANDA | 2025-07-21 |
| phentermine | ANDA | 2025-04-24 |
| phentermine and topiramate | ANDA | 2025-06-24 |
| phentermine and topiramate extended-release | ANDA | 2025-05-21 |
| phentermine hcl | ANDA | 2024-10-15 |
| phentermine hcl c-iv | ANDA | 2025-01-22 |
| phentermine hcl c-iv phentermine hydrochloride | ANDA | 2023-04-12 |
| phentermine hydrochloride | ANDA | 2025-08-01 |
| qsymia | New Drug Application | 2024-10-03 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
PHENTERMINE HYDROCHLORIDE / TOPIRAMATE, QSYMIA, VIVUS | |||
| 2025-06-24 | NPP | ||
HCPCS
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Clinical
Clinical Trials
78 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 4 | 11 | 8 | 20 | 7 | 50 |
| Weight loss | D015431 | — | — | 1 | 2 | — | 5 | 3 | 11 |
| Overweight | D050177 | — | E66.3 | — | 3 | — | 5 | 3 | 11 |
| Pediatric obesity | D063766 | — | — | 1 | 3 | 1 | 3 | — | 8 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | 1 | 1 | 1 | 5 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | 3 | — | 2 | — | 5 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 2 | 1 | — | 4 |
| Bariatric surgery | D050110 | — | — | — | 2 | — | 1 | — | 3 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | 1 | — | 2 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | 1 | — | 1 | 2 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | 1 | — | — | 1 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 1 | — | — | 1 |
| Urinary calculi | D014545 | — | N20.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | — | — | 3 |
| Bulimia | D002032 | — | F50.2 | 1 | 1 | — | — | — | 2 |
| Feeding and eating disorders | D001068 | — | F50 | 1 | 1 | — | — | — | 2 |
| Binge-eating disorder | D056912 | — | F50.2 | 1 | 1 | — | — | — | 2 |
| Body weight | D001835 | EFO_0004338 | — | — | 1 | — | — | 1 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | — | — | — | 1 |
| Nephritis | D009393 | — | N05 | — | 1 | — | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 3 | — | — | — | — | 3 |
| Bulimia nervosa | D052018 | EFO_0005204 | F50.2 | 1 | — | — | — | — | 1 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 2 | 2 |
| Hyperglycemia | D006943 | — | R73.9 | — | — | — | — | 2 | 2 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Diet therapy | D004035 | — | — | — | — | — | — | 1 | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
| Severe acute malnutrition | D000067011 | — | — | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 1 | 1 |
| Enteral nutrition | D004750 | — | — | — | — | — | — | 1 | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Phentermine |
| INN | phentermine |
| Description | Phentermine is a primary amine. It has a role as a dopaminergic agent, an adrenergic agent, a sympathomimetic agent, an appetite depressant, a central nervous system stimulant and a central nervous system drug. It is a conjugate base of a phentermine(1+). |
| Classification | Small molecule |
| Drug class | Appetite suppressant |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(N)Cc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 122-09-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1574 |
| ChEBI ID | 8080 |
| PubChem CID | 4771 |
| DrugBank | DB00191 |
| UNII ID | C045TQL4WP (ChemIDplus, GSRS) |
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Qsymia – Vivus
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Estimated US medical usage
Phentermine
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Trends
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Safety
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No Black-box warning
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6,574 adverse events reported
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