Pheniramine
Naphazoline / Pheniramine, Naphcon-a, Opcon-a, Visine (pheniramine) is a small molecule pharmaceutical. Pheniramine was first approved as Naphcon-a on 1994-06-08. It is used to treat allergic rhinitis perennial, pruritus, and urticaria in the USA.
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Commercial
Trade Name
FDA
EMA
Combinations
Naphcon-a, Opcon-a, Visine (generic drugs available since 2010-09-27)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Naphazoline hydrochloride
+
Pheniramine maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NAPHCON-A | Alcon Research | N-020226 OTC | 1994-06-08 | 1 products, RLD, RS |
| OPCON-A | Bausch Health Companies | N-020065 OTC | 1994-06-08 | 1 products, RLD, RS |
| VISINE | Johnson & Johnson | N-020485 OTC | 1996-01-31 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alahist d | unapproved drug other | 2024-01-27 |
| alahist dm | unapproved drug other | 2024-01-27 |
| cvs pharmacy cold and sore throat | OTC monograph final | 2013-04-01 |
| quality choice cold and sore throat | OTC monograph final | 2016-01-07 |
| theraflu cold and flu | Export only | 2024-01-29 |
| topcare cold and sore throat | OTC monograph final | 2014-05-20 |
| walgreens wal-flu cold and sore throat | OTC monograph final | 2016-03-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| allergic rhinitis perennial | EFO_1001417 | D012221 | J30.89 |
| pruritus | HP_0000989 | D011537 | L29 |
| urticaria | EFO_0005531 | D014581 | L50 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AA: Antihistamines for topical use
— D04AA16: Pheniramine
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB05: Pheniramine
HCPCS
Code | Description |
|---|---|
| J0945 | Injection, brompheniramine maleate, per 10 mg |
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Allergic conjunctivitis | D003233 | EFO_0007141 | H10.44 | — | — | 2 | 1 | — | 3 |
| Dry eye syndromes | D015352 | — | H04.12 | — | — | — | 2 | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pterygium | D011625 | — | H11.0 | — | — | 1 | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 1 | — | — | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Cold temperature | D003080 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Fuchs' endothelial dystrophy | D005642 | EFO_0003946 | H18.51 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Presbyopia | D011305 | — | H52.4 | — | — | — | — | 2 | 2 |
| Intracranial hypertension | D019586 | EFO_1000992 | — | — | — | — | — | 1 | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 1 | 1 |
| Neck pain | D019547 | HP_0030833 | M54.2 | — | — | — | — | 1 | 1 |
| Vitreous detachment | D020255 | EFO_1001238 | H43.81 | — | — | — | — | 1 | 1 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | — | — | 1 | 1 |
| Ocular vision | D014785 | — | — | — | — | — | — | 1 | 1 |
| Renal colic | D056844 | EFO_1001412 | N23 | — | — | — | — | 1 | 1 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pheniramine |
| INN | pheniramine |
| Description | N,N-dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine is a tertiary amino compound and a member of pyridines. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCC(c1ccccc1)c1ccccn1 |
Identifiers
| PDB | — |
| CAS-ID | 86-21-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1193 |
| ChEBI ID | — |
| PubChem CID | 4761 |
| DrugBank | DB01620 |
| UNII ID | 134FM9ZZ6M (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Revenue by drug
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Estimated US medical usage
Pheniramine
+
Naphazoline
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 774 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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9,789 adverse events reported
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