PHENDIMETRAZINE
Bontril Pdm, Phendimetrazine (phendimetrazine) is a small molecule pharmaceutical. Phendimetrazine was first approved as Phendimetrazine tartrate on 1982-01-01. It is used to treat obesity in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Bontril pdm, Phendimetrazine (discontinued: Adphen, Alphazine, Bontril, Cam-metrazine, Di-metrex, Metra, Phendimetrazine, Plegine, Sprx, Statobex, X-trozine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phendimetrazine tartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PHENDIMETRAZINE TARTRATE | Virtus Pharmaceuticals | N-018074 RX | 1982-01-01 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| phendimetrazine | ANDA | 2021-12-31 |
| phendimetrazine tartrate | ANDA | 2024-10-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| obesity | EFO_0001073 | D009765 | E66.9 |
Agency Specific
FDA
EMA
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 2 | 1 | — | — | 1 | 3 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | 2 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | 2 | — | — | — | — | 2 |
| Cicatrix | D002921 | HP_0100699 | L90.5 | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver transplantation | D016031 | EFO_0010682 | — | — | — | — | — | 5 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 1 | 1 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | — | 1 | 1 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
| Hypothermia | D007035 | HP_0002045 | T68 | — | — | — | — | 1 | 1 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | — | — | 1 | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Overweight | D050177 | — | E66.3 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PHENDIMETRAZINE |
| INN | phendimetrazine |
| Description | Phendimetrazine (Bontril, Adipost, Anorex-SR, Appecon, Melfiat, Obezine, Phendiet, Plegine, Prelu-2, Statobex) is a stimulant drug of the morpholine chemical class used as an appetite suppressant.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1C(c2ccccc2)OCCN1C |
Identifiers
| PDB | — |
| CAS-ID | 634-03-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1744 |
| ChEBI ID | — |
| PubChem CID | 12460 |
| DrugBank | DB01579 |
| UNII ID | AB2794W8KV (ChemIDplus, GSRS) |
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Financial
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Estimated US medical usage
Phendimetrazine
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Additional graphs summarizing 15,807 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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2,783 adverse events reported
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