Pexacerfont
Pexacerfont is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target corticotropin-releasing factor receptor 1.
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Events Timeline
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Events
FDA approval date
EMA approval date
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Study first post date
Last update post date
Start date
Primary completion date
Completion date
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Commercial
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | 2 | 1 | — | 1 | 3 |
| Generalized anxiety disorder | D000098647 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | 1 | 2 | — | — | — | 3 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | — | 2 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 2 | — | — | — | 2 |
| Traumatic stress disorders | D040921 | — | — | — | 2 | — | — | — | 2 |
| Syndrome | D013577 | — | — | 1 | 1 | — | — | — | 2 |
| Alcohol-related disorders | D019973 | — | F10 | — | 1 | — | — | — | 1 |
| Depression | D003863 | — | F33.9 | 1 | 1 | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tobacco use disorder | D014029 | — | F17 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pexacerfont |
| INN | pexacerfont |
| Description | Pexacerfont is a pyrazolopyridine. |
| Classification | Small molecule |
| Drug class | CRF-1 (corticotropin releasing factor) receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@@H](C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 |
Identifiers
| PDB | — |
| CAS-ID | 459856-18-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL482950 |
| ChEBI ID | — |
| PubChem CID | 9884366 |
| DrugBank | DB12572 |
| UNII ID | LF1VBG4ZUK (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CRHR1
CRHR1
Organism
Homo sapiens
Gene name
CRHR1
Gene synonyms
CRFR, CRFR1, CRHR
NCBI Gene ID
Protein name
corticotropin-releasing factor receptor 1
Protein synonyms
corticotropin-releasing factor type 1 receptor, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, seven transmembrane helix receptor
Uniprot ID
Mouse ortholog
Crhr1 (12921)
corticotropin-releasing factor receptor 1 (P35347)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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