Pevonedistat
Pevonedistat is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 14 | 7 | 2 | — | — | 20 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 12 | 8 | 2 | — | — | 19 |
| Myeloid leukemia | D007951 | — | C92 | 12 | 6 | 2 | — | — | 17 |
| Myelodysplastic syndromes | D009190 | — | D46 | 8 | 6 | 1 | — | 1 | 14 |
| Preleukemia | D011289 | — | — | 6 | 2 | 1 | — | 1 | 10 |
| Syndrome | D013577 | — | — | 3 | 2 | 1 | — | 1 | 7 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 2 | 2 | 1 | — | — | 4 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 1 | 2 | 1 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 8 | 2 | — | — | — | 8 |
| Lymphoma | D008223 | — | C85.9 | 4 | 1 | — | — | — | 4 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 2 | — | — | — | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | 1 | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 1 | — | — | — | 2 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 2 | 1 | — | — | — | 2 |
| B-cell lymphoma | D016393 | — | — | 2 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 4 | — | — | — | — | 4 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | — | — | — | — | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 2 | — | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | — | — | — | — | 2 |
| Plasma cell neoplasms | D054219 | — | — | 2 | — | — | — | — | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
| Nervous system neoplasms | D009423 | — | — | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pevonedistat |
| INN | pevonedistat |
| Description | Pevonedistat is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. It has a role as an apoptosis inducer and an antineoplastic agent. It is a pyrrolopyrimidine, a secondary amino compound, a member of cyclopentanols, a sulfamidate and a member of indanes. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)OC[C@@H]1C[C@@H](n2ccc3c(N[C@H]4CCc5ccccc54)ncnc32)C[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 905579-51-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1231160 |
| ChEBI ID | — |
| PubChem CID | 16720766 |
| DrugBank | DB11759 |
| UNII ID | S3AZD8D215 (ChemIDplus, GSRS) |
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Safety
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520 adverse events reported
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