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Drug ReportsPermethrin
Permethrin
Elimite, Nix, Permethrin (permethrin) is a small molecule pharmaceutical. Permethrin was first approved as Nix on 1986-03-31. It is used to treat lice infestations and scabies in the USA.
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Elimite, Nix, Permethrin (discontinued: Nix, Permethrin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Permethrin
Tradename
Company
Number
Date
Products
ELIMITEAurobindo PharmaN-019855 RX1989-08-25
1 products, RLD
NIXMedTech ProductsN-019918 OTC1990-05-02
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
elimiteNew Drug Application2024-01-24
germ nix antibacterial hand sanitizerOTC monograph not final2020-03-28
good neighbor pharmacy lice treatmentANDA2017-10-31
good sense lice killing creme rinseANDA2022-11-21
lice treatmentANDA2011-12-20
nixNew Drug Application2021-12-02
nix complete lice treatmentNew Drug Application2020-04-23
nix lice killing creme rinseNew Drug Application2022-02-07
nixoderm unguentoOTC monograph final2016-02-10
permethrinANDA2025-09-25
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
lice infestations—D010373B85.2
scabies—D012532B86
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P03: Ectoparasiticides, incl. scabicides, insecticides and repellents
— P03A: Ectoparasiticides, incl. scabicides
— P03AC: Pyrethrines, incl. synthetic compounds, ectoparasiticides, incl. scabicides
— P03AC04: Permethrin
— P03AC54: Permethrin, combinations
HCPCS
No data
Clinical
Clinical Trials
63 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ScabiesD012532—B8624112322
Lice infestationsD010373—B85.21262314
MalariaD008288EFO_0001068B54——1168
PediculusD010374———21137
Tinea capitisD014006—B35.0—11125
Parasitic diseasesD010272EFO_0001067B88——12—3
ImpetigoD007169EFO_1000714L01———112
TrachomaD014141—A71—1—1—2
InfectionsD007239EFO_0000544———11—2
YawsD015001EFO_0007548A66———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Filarial elephantiasisD004605EFO_0007272B74.0——1—12
TuberculosisD014376EFO_0000774A15-A19——1——1
Pulmonary tuberculosisD014397EFO_1000049A15——1——1
Multidrug-resistant tuberculosisD018088EFO_0007381———1——1
Extensively drug-resistant tuberculosisD054908————1——1
Lyme diseaseD008193—A69.2——1——1
StrongyloidiasisD013322EFO_0007501B78——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101—C90.011———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnemiaD000740EFO_0004272D64.9————22
Tick-borne diseasesD017282——————22
Tick bitesD064927——————22
FilariasisD005368—B74————11
ElephantiasisD004604EFO_0004711—————11
MasculinityD057228——————11
Autonomic nervous system diseasesD001342EFO_0009532G90————11
Chest painD002637—R07.9————11
Chronic painD059350——————11
DengueD003715—A90————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePermethrin
INNpermethrin
Description
Permethrin is a cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups. It has a role as a pyrethroid ester insecticide, a pyrethroid ester acaricide, an agrochemical, an ectoparasiticide and a scabicide. It is a member of cyclopropanes and a cyclopropanecarboxylate ester. It is functionally related to a 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1
Identifiers
PDB—
CAS-ID52645-53-1
RxCUI—
ChEMBL IDCHEMBL1525
ChEBI ID34911
PubChem CID40326
DrugBankDB04930
UNII ID509F88P9SZ (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Permethrin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19,828 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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37,240 adverse events reported
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