Permethrin
Elimite, Nix, Permethrin (permethrin) is a small molecule pharmaceutical. Permethrin was first approved as Nix on 1986-03-31. It is used to treat lice infestations and scabies in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Elimite, Nix (generic drugs available since 1998-01-23)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Permethrin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ELIMITE | Aurobindo Pharma | N-019855 RX | 1989-08-25 | 1 products, RLD |
| NIX | MedTech Products | N-019918 OTC | 1990-05-02 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| elimite | New Drug Application | 2024-01-24 |
| good neighbor pharmacy lice treatment | ANDA | 2017-10-31 |
| good sense lice killing creme rinse | ANDA | 2022-11-21 |
| health mart lice treatment | ANDA | 2020-07-09 |
| leader lice treatment | ANDA | 2021-06-17 |
| lice treatment | ANDA | 2022-04-27 |
| nix | New Drug Application | 2021-12-02 |
| nix complete lice treatment | New Drug Application | 2020-04-23 |
| nix lice killing creme rinse | New Drug Application | 2022-02-07 |
| permethrin | ANDA | 2024-07-29 |
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P03: Ectoparasiticides, incl. scabicides, insecticides and repellents
— P03A: Ectoparasiticides, incl. scabicides
— P03AC: Pyrethrines, incl. synthetic compounds, ectoparasiticides, incl. scabicides
— P03AC04: Permethrin
— P03AC54: Permethrin, combinations
HCPCS
No data
Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Scabies | D012532 | — | B86 | 2 | 3 | 10 | 2 | 3 | 20 |
| Lice infestations | D010373 | — | B85.2 | 1 | 2 | 6 | 2 | 3 | 14 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | 1 | 1 | 7 | 9 |
| Pediculus | D010374 | — | — | — | 2 | 1 | 1 | 3 | 7 |
| Tinea capitis | D014006 | — | B35.0 | — | 1 | 1 | 1 | 2 | 5 |
| Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | 1 | 2 | — | 3 |
| Impetigo | D007169 | EFO_1000714 | L01 | — | — | — | 1 | 1 | 2 |
| Trachoma | D014141 | — | A71 | — | 1 | — | 1 | — | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | 1 | — | 2 |
| Yaws | D015001 | EFO_0007548 | A66 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | 1 | — | — | 1 |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | — | 1 | — | — | 1 |
| Lyme disease | D008193 | — | A69.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 1 | 1 | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | — | — | 2 | 2 |
| Tick-borne diseases | D017282 | — | — | — | — | — | — | 2 | 2 |
| Tick bites | D064927 | — | — | — | — | — | — | 2 | 2 |
| Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | — | — | — | — | 1 | 1 |
| Filariasis | D005368 | — | B74 | — | — | — | — | 1 | 1 |
| Elephantiasis | D004604 | EFO_0004711 | — | — | — | — | — | 1 | 1 |
| Masculinity | D057228 | — | — | — | — | — | — | 1 | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | — | — | — | — | 1 | 1 |
| Chest pain | D002637 | HP_0100749 | R07.9 | — | — | — | — | 1 | 1 |
| Chronic pain | D059350 | HP_0012532 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Permethrin |
| INN | permethrin |
| Description | Permethrin is a cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups. It has a role as a pyrethroid ester insecticide, a pyrethroid ester acaricide, an agrochemical, an ectoparasiticide and a scabicide. It is a member of cyclopropanes and a cyclopropanecarboxylate ester. It is functionally related to a 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 52645-53-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1525 |
| ChEBI ID | 34911 |
| PubChem CID | 40326 |
| DrugBank | DB04930 |
| UNII ID | 509F88P9SZ (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Permethrin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,141 adverse events reported
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