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Drug ReportsPerindopril
Perindopril
Perindopril Erbumine, Prestalia (perindopril) is a small molecule pharmaceutical. Perindopril was first approved as Aceon on 1993-12-30. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. The pharmaceutical is active against angiotensin-converting enzyme.
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EMA approval date
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Study first post date
Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name
Status
Last Update
aceonNew Drug Application2013-03-11
perindopril erbumineANDA2024-03-13
prestaliaNew Drug Application2019-10-25
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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Patent Expiration
Patent
Expires
Flag
FDA Information
Amlodipine Besylate / Perindopril Arginine, Prestalia, Adhera
78469612029-10-05DS, DPU-3
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA04: Perindopril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA04: Perindopril and diuretics
— C09BB: Ace inhibitors and calcium channel blockers
— C09BB04: Perindopril and amlodipine
— C09BX: Ace inhibitors, other combinations in atc
— C09BX01: Perindopril, amlodipine and indapamide
— C09BX02: Perindopril and bisoprolol
— C09BX04: Perindopril, bisoprolol and amlodipine
— C10: Lipid modifying agents
— C10B: Lipid modifying agents, combinations
— C10BX: Lipid modifying agents in combination with other drugs
— C10BX11: Atorvastatin, amlodipine and perindopril
— C10BX12: Atorvastatin, acetylsalicylic acid and perindopril
— C10BX13: Rosuvastatin, perindopril and indapamide
— C10BX14: Rosuvastatin, amlodipine and perindopril
— C10BX15: Atorvastatin and perindopril
HCPCS
No data
Clinical
Clinical Trials
96 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Essential hypertensionD000075222—I10————22
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePerindopril
INNperindopril
Description
Perindopril is an alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is an alpha-amino acid ester, a dicarboxylic acid monoester, an organic heterobicyclic compound and an ethyl ester. It is a conjugate acid of a perindopril(1-).
Classification
Small molecule
Drug classantihypertensives (ACE inhibitors)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCC[C@H](N[C@@H](C)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21)C(=O)OCC
Identifiers
PDB—
CAS-ID82834-16-0
RxCUI—
ChEMBL IDCHEMBL1581
ChEBI ID8024
PubChem CID107807
DrugBankDB00790
UNII IDY5GMK36KGY (ChemIDplus, GSRS)
Target
Agency Approved
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Prestalia – Adhera Therapeutics
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Estimated US medical usage
Perindopril
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,082 documents
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Safety
Black-box Warning
Black-box warning for: Aceon, Perindopril erbumine, Prestalia
Adverse Events
Top Adverse Reactions
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14,670 adverse events reported
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