Definity, Optison(perflutren)
Definity, Luminity, Optison (perflutren) is a small molecule pharmaceutical. Perflutren was first approved as Optison on 1998-05-17. It has been approved in Europe to treat echocardiography.
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Commercial
Trade Name
FDA
EMA
Definity rt
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Perflutren
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DEFINITY | Lantheus Medical Imaging | N-021064 RX | 2001-07-31 | 1 products, RLD, RS |
| DEFINITY RT | Lantheus Medical Imaging | N-021064 RX | 2020-11-17 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| definity | New Drug Application | 2024-03-13 |
| definity rt | New Drug Application | 2024-03-13 |
| optison | New Drug Application | 2025-12-17 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| Q9957 | Injection, perflutren lipid microspheres, per ml |
Clinical
Clinical Trials
175 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 4 | 1 | 1 | 5 | 15 |
| Coronary artery disease | D003324 | — | I25.1 | 2 | 1 | 1 | 1 | 4 | 8 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 2 | 2 | 3 | 2 | 1 | 8 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 2 | 2 | 5 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | 1 | 1 | 1 | 2 | 5 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | 1 | 2 | 4 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | 1 | 2 | 4 |
| Coronary disease | D003327 | — | — | 1 | 1 | 1 | 1 | 1 | 4 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | 3 | 4 |
| Myocardial perfusion imaging | D055414 | — | — | 1 | — | 1 | 1 | — | 3 |
Show 15 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | 1 | 2 | — | 7 | 10 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 2 | 1 | — | 3 | 8 |
| Carcinoma | D002277 | — | C80.0 | 1 | 3 | 1 | — | 2 | 7 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | 2 | — | 1 | 5 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 1 | 1 | — | 2 | 5 |
| Proliferative vitreoretinopathy | D018630 | EFO_1001129 | — | — | 1 | 1 | — | — | 2 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | 1 | — | — | 2 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | 1 | — | 1 | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 1 | 1 | — | — | 1 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 2 | — | — | 6 | 8 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 4 | 1 | — | — | 2 | 7 |
| Infarction | D007238 | EFO_0009463 | — | — | 2 | — | — | 5 | 7 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 3 | — | — | 2 | 7 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 4 | — | — | 1 | 5 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 3 | — | — | 2 | 5 |
| Fibrosis | D005355 | — | — | 2 | 1 | — | — | 2 | 5 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 3 | — | — | 1 | 5 |
| St elevation myocardial infarction | D000072657 | — | — | — | 2 | — | — | 2 | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 2 | — | — | 2 | 4 |
Show 24 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 1 | — | — | — | 1 | 2 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | 1 | — | — | — | 1 | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | — | — | — | — | 2 |
| Pulmonary fibrosis | D011658 | — | J84.10 | 1 | — | — | — | 1 | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 2 | — | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 2 | — | — | — | — | 2 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 1 | — | — | — | — | 1 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | — | 1 |
| Lung transplantation | D016040 | — | — | 1 | — | — | — | — | 1 |
Show 22 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal perforations | D012167 | EFO_1001028 | — | — | — | — | — | 7 | 7 |
| Dissociative disorders | D004213 | — | F44.1 | — | — | — | — | 5 | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 4 | 4 |
| Chest pain | D002637 | — | R07.9 | — | — | — | — | 2 | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Proteinuria | D011507 | — | R80 | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | — | 2 | 2 |
| Endoleak | D057867 | — | — | — | — | — | — | 2 | 2 |
Show 67 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Perflutren |
| INN | perflutren |
| Description | Octafluoropropane is a fluorocarbon that is propane in which all of the hydrogens have been replaced by fluorines. It is a fluorocarbon and a fluoroalkane. It derives from a hydride of a propane. |
| Classification | Small molecule |
| Drug class | blood substitutes and/or diagnostics (perfluorochemicals) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | FC(F)(F)C(F)(F)C(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 76-19-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1663 |
| ChEBI ID | 31980 |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | CK0N3WH0SR (ChemIDplus, GSRS) |
Target
No data
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 4,662 documents
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Safety
Black-box Warning
Black-box warning for: Definity, Definity rt, Optison
Adverse Events
Top Adverse Reactions
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5,402 adverse events reported
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