Definity, Optison(perflutren)
Definity, Luminity, Optison (perflutren) is a small molecule pharmaceutical. Perflutren was first approved as Optison on 1998-05-17. It has been approved in Europe to treat echocardiography.
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Commercial
Trade Name
FDA
EMA
Definity rt
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Perflutren
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DEFINITY | Lantheus Medical Imaging | N-021064 RX | 2001-07-31 | 1 products, RLD, RS |
| DEFINITY RT | Lantheus Medical Imaging | N-021064 RX | 2020-11-17 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| definity | New Drug Application | 2024-03-13 |
| definity rt | New Drug Application | 2024-03-13 |
| optison | New Drug Application | 2024-01-11 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| Q9957 | Injection, perflutren lipid microspheres, per ml |
Clinical
Clinical Trials
164 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 3 | 1 | 1 | 5 | 14 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | 1 | 1 | 1 | 5 | 8 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 2 | 2 | 2 | 2 | 1 | 7 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 2 | 2 | 5 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | — | — | 1 | 3 | 5 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | 1 | 1 | 1 | 2 | 5 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | 1 | 2 | 4 |
| Coronary disease | D003327 | — | — | 1 | 1 | 1 | 1 | 1 | 4 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | 1 | 3 | 4 |
| Myocardial perfusion imaging | D055414 | — | — | — | — | 1 | 1 | 1 | 3 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | 1 | 2 | — | 6 | 9 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 1 | 1 | — | 3 | 7 |
| Carcinoma | D002277 | — | C80.0 | 1 | 3 | 1 | — | 2 | 7 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 1 | 1 | — | 2 | 5 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | 2 | — | — | 4 |
| Proliferative vitreoretinopathy | D018630 | EFO_1001129 | — | — | 1 | 1 | — | — | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | 1 | 1 | — | 1 | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | 1 | — | — | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 1 | 1 | — | — | 1 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | 1 | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 2 | — | — | 6 | 8 |
| Fibrosis | D005355 | — | — | 3 | 1 | — | — | 3 | 7 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 4 | 1 | — | — | 2 | 7 |
| Infarction | D007238 | EFO_0009463 | — | — | 2 | — | — | 5 | 7 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | 3 | — | — | 2 | 7 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 4 | — | — | 2 | 6 |
| Dissociative disorders | D004213 | — | F44.1 | — | 1 | — | — | 4 | 5 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 4 | — | — | 1 | 5 |
| St elevation myocardial infarction | D000072657 | — | — | — | 2 | — | — | 2 | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 2 | — | — | 2 | 4 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung diseases | D008171 | HP_0002088 | J98.4 | 2 | — | — | — | 1 | 3 |
| Melanoma | D008545 | — | — | 1 | — | — | — | 1 | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | — | — | — | — | 2 |
| Pulmonary fibrosis | D011658 | — | — | 1 | — | — | — | 1 | 2 |
| Pulmonary embolism | D011655 | HP_0002204 | I26 | 1 | — | — | — | — | 1 |
| Embolism | D004617 | — | — | 1 | — | — | — | — | 1 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 1 | — | — | — | — | 1 |
| Lung transplantation | D016040 | — | — | 1 | — | — | — | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
| Emphysema | D004646 | EFO_0000464 | J43 | 1 | — | — | — | — | 1 |
Show 19 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal perforations | D012167 | EFO_1001028 | — | — | — | — | — | 5 | 5 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 4 | 4 |
| Chest pain | D002637 | HP_0100749 | R07.9 | — | — | — | — | 2 | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 2 | 2 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | — | 2 | 2 |
| Endoleak | D057867 | — | — | — | — | — | — | 2 | 2 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 2 | 2 |
Show 66 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Perflutren |
| INN | perflutren |
| Description | Octafluoropropane is a fluorocarbon that is propane in which all of the hydrogens have been replaced by fluorines. It is a fluorocarbon and a fluoroalkane. It derives from a hydride of a propane. |
| Classification | Small molecule |
| Drug class | blood substitutes and/or diagnostics (perfluorochemicals) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | FC(F)(F)C(F)(F)C(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 76-19-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1663 |
| ChEBI ID | 31980 |
| PubChem CID | 6432 |
| DrugBank | DB00556 |
| UNII ID | CK0N3WH0SR (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Definity, Definity rt, Optison
Adverse Events
Top Adverse Reactions
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4,759 adverse events reported
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