Perflubutane
Perflubutane is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
63 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | — | 3 | 1 | 1 | 5 |
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | 1 | 1 | 1 | — | 3 |
| Peptic ulcer | D010437 | HP_0004398 | K27 | — | — | — | 2 | — | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | — | 1 | 1 | — | 2 |
| Rectal diseases | D012002 | — | — | — | — | — | 1 | — | 1 |
| Anesthesia | D000758 | — | — | — | — | — | 1 | — | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | 1 | — | 1 |
| Intravesical administration | D000283 | — | — | — | — | — | 1 | — | 1 |
| Cystitis | D003556 | EFO_1000025 | N30 | — | — | — | 1 | — | 1 |
| Seroma | D049291 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | 1 | — | 6 | 7 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | 1 | — | 5 | 6 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 1 | — | 2 | 3 |
| Infertility | D007246 | HP_0000789 | — | — | 1 | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 1 | — | — | — | 2 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
| Congenital adrenal hyperplasia | D000312 | — | E25.0 | 1 | 1 | — | — | — | 1 |
| Addison disease | D000224 | — | E27.1 | 1 | 1 | — | — | — | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 1 | — | — | — | 1 |
| Cardiac catheterization | D006328 | — | — | — | 1 | — | — | — | 1 |
| Echocardiography | D004452 | — | — | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ulcer | D014456 | MPATH_579 | — | 2 | — | — | — | — | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | 1 | 2 |
| Gastric emptying | D005746 | — | — | 1 | — | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 1 | — | — | — | — | 1 |
| Vaginal neoplasms | D014625 | — | C52 | 1 | — | — | — | — | 1 |
| Vulvar neoplasms | D014846 | — | C51 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | — | 3 | 3 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | — | 1 | 1 |
| Electroretinography | D004596 | — | — | — | — | — | — | 1 | 1 |
| Colonic neoplasms | D003110 | — | C18 | — | — | — | — | 1 | 1 |
| Focal nodular hyperplasia | D020518 | — | — | — | — | — | — | 1 | 1 |
| Temporomandibular joint disorders | D013705 | — | M26.6 | — | — | — | — | 1 | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | — | 1 | 1 |
| Hepatitis b | D006509 | — | — | — | — | — | — | 1 | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | — | — | — | — | 1 | 1 |
| Nasopharyngeal carcinoma | D000077274 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Perflubutane |
| INN | perflubutane |
| Description | Perflubutane is a fluorocarbon that is butane in which all of the hydrogens have been replaced by fluorines. Microbubbles of preflubutane are used in the ultrasound contrast agent BR14. It has a role as an ultrasound contrast agent. It is a gas molecular entity, a fluorocarbon and a fluoroalkane. |
| Classification | Small molecule |
| Drug class | blood substitutes and/or diagnostics (perfluorochemicals) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 355-25-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2104979 |
| ChEBI ID | — |
| PubChem CID | 9638 |
| DrugBank | — |
| UNII ID | SE4TWR0K2C (ChemIDplus, GSRS) |
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Safety
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