Therapeutic Area | MeSH |
---|---|
nervous system diseases | D009422 |
signs and symptoms pathological conditions | D013568 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
FYCOMPA | Catalyst Pharmaceuticals | N-202834 RX | 2012-10-22 | 6 products, RLD, RS |
FYCOMPA | Catalyst Pharmaceuticals | N-208277 RX | 2016-04-29 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
fycompa | New Drug Application | 2024-01-05 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
seizures | — | D012640 | G40.4 |
partial epilepsies | EFO_0004263 | D004828 | — |
tonic-clonic epilepsy | EFO_0007262 | D004830 | — |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Seizures | D012640 | — | G40.4 | 1 | 9 | 9 | 4 | 10 | 32 |
Epilepsy | D004827 | EFO_0000474 | G40.9 | 2 | 8 | 3 | 7 | 8 | 28 |
Healthy volunteers/patients | — | — | — | 8 | — | — | 1 | — | 9 |
Complex partial epilepsy | D017029 | EFO_1000877 | — | 2 | — | 1 | 1 | 2 | 6 |
Tonic-clonic epilepsy | D004830 | EFO_0007262 | — | — | — | — | 1 | 4 | 5 |
Partial epilepsies | D004828 | EFO_0004263 | — | — | — | — | 2 | — | 2 |
Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Parkinson disease | D010300 | EFO_0002508 | G20 | — | 6 | 5 | — | — | 11 |
Peripheral nervous system diseases | D010523 | — | G64 | — | 2 | 1 | — | — | 2 |
Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 2 | 2 | — | — | 2 |
Lennox gastaut syndrome | D065768 | — | G40.81 | — | — | 1 | — | 1 | 2 |
Neuralgia | D009437 | EFO_0009430 | — | — | 2 | 1 | — | — | 2 |
Postherpetic neuralgia | D051474 | — | — | — | 2 | 1 | — | — | 2 |
Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Dyskinesias | D020820 | — | G24 | — | 2 | — | — | — | 2 |
Epileptic syndromes | D000073376 | — | — | — | 1 | — | — | — | 1 |
Glioma | D005910 | EFO_0000520 | — | 1 | 1 | — | — | — | 1 |
Small fiber neuropathy | D000071075 | — | — | — | 1 | — | — | — | 1 |
Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | — | — | 2 | 2 |
Generalized epilepsy | D004829 | — | — | — | — | — | — | 1 | 1 |
Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | — | — | — | 1 | 1 |
Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | — | — | — | 1 | 1 |
Sclerosis | D012598 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Perampanel |
INN | perampanel |
Description | Perampanel is a member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. It has a role as an AMPA receptor antagonist and an anticonvulsant. It is a pyridone, a nitrile and a member of bipyridines. It is functionally related to a benzonitrile. |
Classification | Small molecule |
Drug class | ionotropic non-NMDA (N-methyl D-aspartate) glutamate receptors [AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor) and/or KA (kainite antagonist) receptors]: antagonists |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2ccccc2)c1=O |
PDB | — |
CAS-ID | 380917-97-5 |
RxCUI | — |
ChEMBL ID | CHEMBL1214124 |
ChEBI ID | 71013 |
PubChem CID | 9924495 |
DrugBank | DB08883 |
UNII ID | H821664NPK (ChemIDplus, GSRS) |