Pentamidine - PharmaKB

Pentamidine

Nebupent, Pentam, Pentamidine Isethionate (pentamidine) is a small molecule pharmaceutical. Pentamidine was first approved as Pentam on 1984-10-16. It is used to treat pneumocystis pneumonia, protozoan infections, trypanosomiasis, and visceral leishmaniasis in the USA.

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
respiratory tract diseases	D012140

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EMA

Brand Name	Status	Last Update
nebupent	New Drug Application	2024-10-15
pentam 300	New Drug Application	2022-09-13
pentamidine isethionate	ANDA	2024-03-18

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ATC Codes

P: Antiparasitic products, insecticides and repellents

— P01: Antiprotozoals

— P01C: Agents against leishmaniasis and trypanosomiasis

— P01CX: Other agents against leishmaniasis and trypanosomiasis in atc

— P01CX01: Pentamidine isethionate

HCPCS

Code	Description
J2545	Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg
J7676	Pentamidine isethionate, inhalation solution, compounded product, administered through dme, unit dose form, per 300 mg
S0080	Injection, pentamidine isethionate, 300 mg
S9061	Home administration of aerosolized drug therapy (e.g., pentamidine); administrative services, professional pharmacy services, care coordination, all necessary supplies and equipment (drugs and nursing visits coded separately), per diem

Clinical

Clinical Trials

47 clinical trials

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Indications Phases 4

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Kidney diseases	D007674	EFO_0003086	N08	1	1	—	—	—	1
Kidney transplantation	D016030	—	—	1	1	—	—	—	1

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Pentamidine
INN	pentamidine
Description	Pentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. It has a role as a trypanocidal drug, an antifungal agent, a NMDA receptor antagonist, an anti-inflammatory agent, a chemokine receptor 5 antagonist, an EC 2.3.1.48 (histone acetyltransferase) inhibitor, a calmodulin antagonist, a S100 calcium-binding protein B inhibitor and a xenobiotic. It is a carboxamidine, a diether and an aromatic ether. It is a conjugate base of a pentamidinium(2+).
Classification	Small molecule
Drug class	pentamidine derivatives/analogues
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1