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AboutPricing
Drug ReportsPentamidine
Pentamidine
Nebupent, Pentam, Pentamidine Isethionate (pentamidine) is a small molecule pharmaceutical. Pentamidine was first approved as Pentam on 1984-10-16. It is used to treat pneumocystis pneumonia, protozoan infections, trypanosomiasis, and visceral leishmaniasis in the USA.
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Drug
Target
Variants
Financial
Trends
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Events Timeline
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5Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
nebupentNew Drug Application2024-10-15
pentam 300New Drug Application2022-09-13
pentamidine isethionateANDA2025-04-08
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01C: Agents against leishmaniasis and trypanosomiasis
— P01CX: Other agents against leishmaniasis and trypanosomiasis in atc
— P01CX01: Pentamidine isethionate
HCPCS
Code
Description
J2545
Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg
J7676
Pentamidine isethionate, inhalation solution, compounded product, administered through dme, unit dose form, per 300 mg
S0080
Injection, pentamidine isethionate, 300 mg
S9061
Home administration of aerosolized drug therapy (e.g., pentamidine); administrative services, professional pharmacy services, care coordination, all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
Clinical
Clinical Trials
46 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Kidney diseasesD007674EFO_0003086N0811———1
Kidney transplantationD016030——11———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePentamidine
INNpentamidine
Description
Pentamidine is a diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. It has a role as a trypanocidal drug, an antifungal agent, a NMDA receptor antagonist, an anti-inflammatory agent, a chemokine receptor 5 antagonist, an EC 2.3.1.48 (histone acetyltransferase) inhibitor, a calmodulin antagonist, a S100 calcium-binding protein B inhibitor and a xenobiotic. It is a carboxamidine, a diether and an aromatic ether. It is a conjugate base of a pentamidinium(2+).
Classification
Small molecule
Drug classpentamidine derivatives/analogues
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Structure (InChI/SMILES or Protein Sequence)
N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1
Identifiers
PDB—
CAS-ID100-33-4
RxCUI—
ChEMBL IDCHEMBL55
ChEBI ID45081
PubChem CID4735
DrugBankDB00738
UNII ID673LC5J4LQ (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,907 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,008 adverse events reported
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