Penicillamine
Cuprimine, Depen, Penicillamine (penicillamine) is a small molecule pharmaceutical. Penicillamine was first approved as Depen on 1982-01-01. It is used to treat biliary liver cirrhosis, cystinuria, hepatolenticular degeneration, lead poisoning, and mercury poisoning amongst others in the USA. It is known to target delta-type opioid receptor and solute carrier organic anion transporter family member 1C1.
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Commercial
Therapeutic Areas
Trade Name
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Cuprimine, Depen (generic drugs available since 2019-05-07)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillamine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DEPEN | Mylan | N-019854 RX | 1982-01-01 | 1 products, RLD, RS |
| CUPRIMINE | Bausch Health Companies | N-019853 RX | 1982-01-01 | 1 products, RLD, RS |
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatolenticular degeneration | D006527 | Orphanet_905 | E83.01 | 1 | — | 2 | 1 | 1 | 5 |
| Cystinuria | D003555 | — | E72.01 | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | 1 | 1 | — | — | 1 |
| Lead poisoning | D007855 | — | T56.0 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system neoplasms | D016543 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Penicillamine |
| INN | penicillamine |
| Description | D-penicillamine is an optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning. It has a role as a chelator, an antirheumatic drug, a drug allergen and a copper chelator. It is a penicillamine and a non-proteinogenic alpha-amino acid. It is an enantiomer of a L-penicillamine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(S)[C@@H](N)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 52-67-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1430 |
| ChEBI ID | 7959 |
| PubChem CID | 5852 |
| DrugBank | DB00859 |
| UNII ID | GNN1DV99GX (ChemIDplus, GSRS) |
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Penicillamine
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566 adverse events reported
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