PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
AboutPricing
Drug ReportsPemetrexed
Alimta(pemetrexed)
Alimta, Armisarte, Axtle, Ciambra, Pemetrexed, Pemfexy (pemetrexed) is a small molecule pharmaceutical. Pemetrexed was first approved as Alimta on 2004-02-04. It is used to treat mesothelial neoplasms and non-small-cell lung carcinoma in the USA. It has been approved in Europe to treat mesothelioma and non-small-cell lung carcinoma. The pharmaceutical is active against dihydrofolate reductase. In addition, it is known to target proton-coupled folate transporter, thymidylate synthase, and trifunctional purine biosynthetic protein adenosine-3.
Download report
Favorite
Top 200 Pharmaceuticals by Retail Sales
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
respiratory tract diseasesD012140
Trade Name
FDA
EMA
Alimta, Pemetrexed, Pemetrexed ditromethamine, Pemfexy (discontinued: Pemetrexed, Pemetrexed ditromethamine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pemetrexed disodium
Tradename
Company
Number
Date
Products
PEMETREXED DISODIUMHospiraN-214218 RX2022-06-22
3 products, RLD, RS
ALIMTAEli LillyN-021462 RX2004-02-04
2 products, RLD, RS
PEMETREXED DISODIUMSandozN-214657 RX2022-05-26
3 products, RLD, RS
PEMETREXEDShilpa MedicareN-215179 RX2023-05-22
3 products, RLD, RS
Show 1 discontinued
Pemetrexed
Tradename
Company
Number
Date
Products
PEMETREXEDAllerganN-208419 RX2020-08-21
3 products, RLD, RS
PEMFEXYEagle PharmaceuticalsN-209472 RX2020-02-08
1 products, RLD, RS
Pemetrexed ditromethamine
Tradename
Company
Number
Date
Products
PEMETREXED DITROMETHAMINEHospiraN-208746 RX2022-06-10
2 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
alimtaNew Drug Application2023-05-19
axtleNew Drug Application2025-06-18
pemetrexedNew Drug Application2025-07-30
pemetrexed dipotassiumNew Drug Application2025-02-05
pemetrexed disodiumANDA2022-11-15
pemetrexed pemetrexedANDA2025-04-01
pemfexyNew Drug Application2023-05-15
pemrydi rtuNew Drug Application2024-11-11
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Pemetrexed, Pemfexy, Eagle Pharms
96049902035-10-28DP
Pemetrexed Disodium, Pemetrexed, Shilpa
111478172035-03-26DP
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01B: Antimetabolites
L01BA: Folic acid analogs, antimetabolites
L01BA04: Pemetrexed
HCPCS
Code
Description
J9304
Injection, pemetrexed (pemfexy), 10 mg
J9305
Injection, pemetrexed, not otherwise specified, 10 mg
Clinical
Clinical Trials
1377 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD0022891755292462055933
Lung neoplasmsD008175C34.901274271871245731
NeoplasmsD009369C8094451423134
MesotheliomaD008654C4536631247101
Malignant mesotheliomaD0000860023362123695
Neoplasm metastasisD009362EFO_0009708193562458
AdenocarcinomaD00023093195757
Adenocarcinoma of lungD00007719263055750
Breast neoplasmsD001943EFO_0003869C501119127
Meningeal carcinomatosisD055756EFO_10010129132320
Show 4 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277C80.0204013167
Brain neoplasmsD001932EFO_0003833C71219425
Small cell lung carcinomaD055752614322
Head and neck neoplasmsD006258814221
Ovarian neoplasmsD010051EFO_0003893C56911118
Urologic neoplasmsD014571C64-C6869113
RecurrenceD0120082101113
Transitional cell carcinomaD002295210212
Uterine cervical neoplasmsD00258334512
Stomach neoplasmsD013274EFO_0003897C1657110
Show 22 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179181829
MelanomaD0085459812
Renal cell carcinomaD002292EFO_0000376759
SarcomaD012509369
Squamous cell carcinoma of head and neckD000077195558
ImmunotherapyD007167527
Peritoneal neoplasmsD010534357
Pancreatic ductal carcinomaD021441737
Endometrial neoplasmsD016889EFO_0004230446
Prostatic neoplasmsD011471C61346
Show 75 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Primary myelofibrosisD055728D47.422
Uveal neoplasmsD014604EFO_100123022
Uveal melanomaD00009894322
Skin neoplasmsD012878EFO_0004198C4411
Cutaneous malignant melanomaD00009614211
Non-hodgkin lymphomaD008228C85.911
Hodgkin diseaseD006689C8111
PharmacokineticsD01059911
Medical sociologyD01296211
LeukemiaD007938C9511
Show 13 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PulpitisD011671EFO_1001139K04.044
DiseaseD004194EFO_0000408R6922
NeutropeniaD009503D7022
MethylationD00874511
Multiple primary neoplasmsD00937811
LasersD00783411
PeriodontitisD010518EFO_0000649K05.311
Periapical periodontitisD010485EFO_1001391K04.511
Wound healingD014945GO_004206011
Nonvital toothD01955311
Show 14 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common namePemetrexed
INNpemetrexed
Description
Pemetrexed, sold under the brand name Alimta among others, is a chemotherapy medication for the treatment of pleural mesothelioma and non-small cell lung cancer (NSCLC)..
Classification
Small molecule
Drug classantineoplastic thymidylate synthetase inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1
Identifiers
PDB
CAS-ID137281-23-3
RxCUI
ChEMBL IDCHEMBL225072
ChEBI ID63616
PubChem CID446556
DrugBankDB00642
UNII ID04Q9AIZ7NO (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Pemfexy Eagle Pharmaceuticals
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Alimta Eli Lilly
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 24,804 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
33,198 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use