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Drug ReportsPelabresib
Pelabresib
Pelabresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 4.
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Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80211——3
Essential thrombocythemiaD013920—D47.3111——2
Primary myelofibrosisD055728—D47.4111——2
ThrombocytosisD013922—D75.83111——2
Hematologic neoplasmsD019337——1—1——2
Polycythemia veraD011087—D45——1——1
PolycythemiaD011086EFO_0005804D75.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C9511———1
Myelodysplastic syndromesD009190—D4611———1
Myeloid leukemia acuteD015470—C92.011———1
Myeloproliferative disordersD009196—D47.111———1
Hematologic diseasesD006402EFO_0005803D75.911———1
Precancerous conditionsD011230——11———1
Myelodysplastic-myeloproliferative diseasesD054437——11———1
Myeloid leukemiaD007951—C9211———1
PreleukemiaD011289——11———1
Bone marrow diseasesD001855——11———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101—C90.01————1
Plasma cell neoplasmsD054219——1————1
LymphomaD008223—C85.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePelabresib
INNpelabresib
Description
Pelabresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 4.
Classification
Small molecule
Drug classextra-terminal motif (BET) family of bromodomain (BRD) proteins
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Structure (InChI/SMILES or Protein Sequence)
Cc1noc2c1-c1ccccc1C(c1ccc(Cl)cc1)=N[C@H]2CC(N)=O
Identifiers
PDB—
CAS-ID1380087-89-7
RxCUI—
ChEMBL IDCHEMBL4303404
ChEBI ID—
PubChem CID57389999
DrugBankDB17129
UNII IDU4017GUQ06 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
BRD4
BRD4
Organism
Homo sapiens
Gene name
BRD4
Gene synonyms
HUNK1
NCBI Gene ID
Protein name
bromodomain-containing protein 4
Protein synonyms
chromosome-associated protein, female sterile homeotic related gene 4, mitotic chromosome-associated protein, Protein HUNK1
Uniprot ID
Mouse ortholog
Brd4 (57261)
bromodomain-containing protein 4 (Q9ESU6)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 506 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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33 adverse events reported
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