Pelabresib
Pelabresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 4.
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FDA approval date
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Study first post date
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Commercial
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Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 1 | 1 | — | — | 3 |
| Essential thrombocythemia | D013920 | — | D47.3 | 1 | 1 | 1 | — | — | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | 1 | 1 | — | — | 2 |
| Thrombocytosis | D013922 | — | D75.83 | 1 | 1 | 1 | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | 1 | — | — | 2 |
| Polycythemia vera | D011087 | — | D45 | — | — | 1 | — | — | 1 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 1 | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | 1 | — | — | — | 1 |
| Precancerous conditions | D011230 | — | — | 1 | 1 | — | — | — | 1 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 1 | 1 | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 1 | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | 1 | — | — | — | 1 |
| Bone marrow diseases | D001855 | — | — | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pelabresib |
| INN | pelabresib |
| Description | Pelabresib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bromodomain-containing protein 4. |
| Classification | Small molecule |
| Drug class | extra-terminal motif (BET) family of bromodomain (BRD) proteins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1noc2c1-c1ccccc1C(c1ccc(Cl)cc1)=N[C@H]2CC(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1380087-89-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4303404 |
| ChEBI ID | — |
| PubChem CID | 57389999 |
| DrugBank | DB17129 |
| UNII ID | U4017GUQ06 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
BRD4
BRD4
Organism
Homo sapiens
Gene name
BRD4
Gene synonyms
HUNK1
NCBI Gene ID
Protein name
bromodomain-containing protein 4
Protein synonyms
chromosome-associated protein, female sterile homeotic related gene 4, mitotic chromosome-associated protein, Protein HUNK1
Uniprot ID
Mouse ortholog
Brd4 (57261)
bromodomain-containing protein 4 (Q9ESU6)
Variants
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 510 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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33 adverse events reported
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