Oncaspar(pegaspargase)
Oncaspar (pegaspargase) is an enzyme pharmaceutical. Pegaspargase was first approved as Oncaspar on 1994-02-01. It is used to treat b-cell chronic lymphocytic leukemia, blast crisis, non-hodgkin lymphoma, and precursor cell lymphoblastic leukemia-lymphoma in the USA. It has been approved in Europe to treat precursor cell lymphoblastic leukemia-lymphoma.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Oncaspar
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| lyophilized pegaspargase | Export only | 2020-08-03 |
| oncaspar | Biologic Licensing Application | 2024-10-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-hodgkin lymphoma | — | D008228 | C85.9 |
| precursor cell lymphoblastic leukemia-lymphoma | — | D054198 | C91.0 |
| b-cell chronic lymphocytic leukemia | — | D015451 | C91.1 |
| blast crisis | — | D001752 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
pegaspargase, Oncaspar, Servier Pharmaceuticals LLC | |||
| 2101-02-01 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9266 | Injection, pegaspargase, per single dose vial |
Clinical
Clinical Trials
220 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 33 | 75 | 49 | 3 | 18 | 160 |
| Leukemia | D007938 | — | C95 | 32 | 70 | 46 | 3 | 15 | 149 |
| Lymphoid leukemia | D007945 | — | C91 | 29 | 62 | 39 | 2 | 14 | 132 |
| Lymphoma | D008223 | — | C85.9 | 10 | 54 | 18 | 3 | 8 | 88 |
| T-cell lymphoma | D016399 | — | — | 6 | 26 | 6 | 3 | 7 | 46 |
| T-cell lymphoma peripheral | D016411 | — | — | 4 | 25 | 6 | 2 | 7 | 42 |
| Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | 1 | 20 | 4 | 1 | 5 | 30 |
| Syndrome | D013577 | — | — | 2 | — | 1 | 1 | — | 4 |
| Hematologic neoplasms | D019337 | — | — | 1 | 1 | — | 1 | — | 3 |
| Hemophagocytic lymphohistiocytosis | D051359 | — | D76.1 | — | — | 2 | 1 | — | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 16 | 7 | — | — | 26 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 5 | 8 | 5 | — | — | 16 |
| Philadelphia chromosome | D010677 | — | — | 2 | 4 | 4 | — | — | 9 |
| Recurrence | D012008 | — | — | 3 | 6 | 1 | — | — | 9 |
| Acute disease | D000208 | — | — | 4 | 2 | 1 | — | — | 7 |
| T-cell leukemia | D015458 | — | — | 2 | 3 | 2 | — | — | 5 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | 1 | 2 | — | — | 3 |
| Central nervous system neoplasms | D016543 | — | — | — | — | 2 | — | — | 2 |
| B-cell leukemia | D015448 | — | — | — | 2 | 1 | — | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 3 | 3 | — | — | — | 6 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | — | 3 | — | — | — | 3 |
| Precursor b-cell lymphoblastic leukemia-lymphoma | D015452 | — | — | 1 | 3 | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | — | — | — | 3 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 2 | — | — | 1 | 3 |
| Myeloid leukemia | D007951 | — | C92 | — | 2 | — | — | — | 2 |
| Treatment refusal | D016312 | — | — | — | 2 | — | — | — | 2 |
| Residual neoplasm | D018365 | — | — | — | 1 | — | — | 1 | 2 |
| Inborn genetic diseases | D030342 | EFO_0000508 | — | — | 1 | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mucositis | D052016 | EFO_1001898 | — | — | — | — | — | 1 | 1 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 1 | 1 |
| Hyperlipoproteinemias | D006951 | — | — | — | — | — | — | 1 | 1 |
| Eye abnormalities | D005124 | — | Q15.9 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pegaspargase |
| INN | pegaspargase |
| Description | Pegaspargase, sold under the brand name Oncaspar, is a medication used in the treatment of acute lymphoblastic leukemia (ALL). Often it is used together with anthracycline, vincristine, and corticosteroids (for example prednisone and dexamethasone). Pegaspargase can be administered either via an intravenous infusion or a intramuscular injection.
|
| Classification | Enzyme |
| Drug class | enzymes; PEGylated compounds, covalent attachment of macrogol (polyethylene glycol) polymer |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108546 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00059 |
| UNII ID | 7D96IR0PPM (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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12,720 adverse events reported
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