Patupilone
Patupilone is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
142 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 2 | 10 | 8 | 4 | — | 23 |
| Renal insufficiency | D051437 | — | N19 | 1 | 2 | 3 | 1 | — | 7 |
| Kidney transplantation | D016030 | — | — | — | — | — | 1 | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | 1 | — | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | 1 | — | 1 |
| Aneurysm | D000783 | — | I72.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 18 | 7 | 5 | — | — | 29 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 12 | 3 | — | — | 17 |
| Lymphoma | D008223 | — | C85.9 | 2 | 6 | 3 | — | — | 11 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 4 | 6 | 2 | — | 1 | 11 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 6 | 1 | — | 2 | 9 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 5 | 2 | — | — | 7 |
| Leukemia | D007938 | — | C95 | 1 | 3 | 3 | — | — | 7 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 3 | 2 | — | — | 6 |
| Multiple myeloma | D009101 | — | C90.0 | — | 2 | 3 | — | — | 5 |
| Plasma cell neoplasms | D054219 | — | — | — | 2 | 3 | — | — | 5 |
Show 22 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 2 | 9 | — | — | — | 9 |
| Recurrence | D012008 | — | — | 2 | 9 | — | — | — | 9 |
| Carcinoma | D002277 | — | C80.0 | — | 7 | — | — | — | 7 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | 4 | — | — | 2 | 6 |
| Healthy volunteers/patients | — | — | — | 5 | 1 | — | — | — | 5 |
| Colorectal neoplasms | D015179 | — | — | 1 | 4 | — | — | — | 4 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 3 | — | — | — | 4 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 2 | 3 | — | — | — | 4 |
| Colonic neoplasms | D003110 | — | C18 | 2 | 2 | — | — | — | 3 |
| Head and neck neoplasms | D006258 | — | — | 2 | 2 | — | — | — | 3 |
Show 86 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system neoplasms | D016543 | — | — | 2 | — | — | — | — | 2 |
| Nervous system neoplasms | D009423 | — | — | 2 | — | — | — | — | 2 |
| Neutropenia | D009503 | — | D70 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Intestinal neoplasms | D007414 | — | C26.0 | 1 | — | — | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
| Alveolar bone loss | D016301 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | — | 1 | 1 |
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | — | 1 | 1 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | — | 1 | 1 |
| Iron-deficiency anemia | D018798 | — | D50 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Reperfusion injury | D015427 | — | — | — | — | — | — | 1 | 1 |
| Myocardial reperfusion injury | D015428 | EFO_0002687 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Patupilone |
| INN | patupilone |
| Description | Epothilone B is an epithilone that is epithilone D in which the double bond in the macrocyclic ring has been oxidised to the corresponding epoxide (the S,S stereoisomer). It has a role as an apoptosis inducer, an antineoplastic agent and a microtubule-stabilising agent. It is an epothilone and an epoxide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C/C(=C\c1csc(C)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1 |
Identifiers
| PDB | — |
| CAS-ID | 152044-54-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL94657 |
| ChEBI ID | 31550 |
| PubChem CID | — |
| DrugBank | DB03010 |
| UNII ID | UEC0H0URSE (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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16 adverse events reported
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