Signifor lar kit, Signifor(pasireotide)
Signifor (pasireotide) is a protein pharmaceutical. Pasireotide was first approved as Signifor on 2012-04-24. It is used to treat cushing syndrome in the USA. It has been approved in Europe to treat acromegaly and pituitary acth hypersecretion. The pharmaceutical is active against somatostatin receptor type 3, somatostatin receptor type 1, somatostatin receptor type 2, and somatostatin receptor type 5.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Signifor
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| signifor | New Drug Application | 2024-07-16 |
| signifor lar | New Drug Application | 2024-07-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| cushing syndrome | EFO_0003099 | D003480 | E24 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
PASIREOTIDE PAMOATE, SIGNIFOR LAR KIT, RECORDATI RARE | |||
| 2025-06-29 | ODE-268 | ||
HCPCS
Code | Description |
|---|---|
| J2502 | Injection, pasireotide long acting, 1 mg |
Clinical
Clinical Trials
84 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | — | — | 1 | 1 | 2 |
| Acth-secreting pituitary adenoma | D049913 | — | — | — | — | — | 1 | 1 | 2 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 1 | — | 1 | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | — | 1 | — | 1 |
| Melanoma | D008545 | — | — | — | — | — | 1 | — | 1 |
| Pituitary neoplasms | D010911 | — | — | — | — | — | 1 | — | 1 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | — | 1 | — | 1 |
| Dumping syndrome | D004377 | EFO_1001307 | K91.1 | — | — | — | 1 | — | 1 |
| Acromegaly | D000172 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Carcinoid tumor | D002276 | — | D3A.00 | — | 1 | — | — | — | 1 |
| Hypoglycemia | D007003 | — | E16.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pasireotide |
| INN | pasireotide |
| Description | Pasireotide is a six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease. It has a role as an antineoplastic agent. It is a homodetic cyclic peptide and a peptide hormone. It is a conjugate base of a pasireotide(2+). |
| Classification | Protein |
| Drug class | peptides: inhibition of growth hormone release |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 396091-73-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3039583 |
| ChEBI ID | — |
| PubChem CID | 9941444 |
| DrugBank | DB06663 |
| UNII ID | 98H1T17066 (ChemIDplus, GSRS) |
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Safety
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2,438 adverse events reported
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