Paromomycin - PharmaKB

Paromomycin

Paromomycin (paromomycin) is a small molecule pharmaceutical. Paromomycin was first approved as Humatin on 1982-01-01. It is used to treat amebiasis, cryptosporidiosis, and protozoan infections in the USA.

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Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
digestive system diseases	D004066
animal diseases	D000820

Trade Name

FDA

EMA

Paromomycin (discontinued: Humatin, Paromomycin)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

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Labels

FDA

EMA

Brand Name	Status	Last Update
emergency preparedness	OTC monograph final	2010-06-02
good neighbor pharmacy emergency preparedness and first aid contains 167 pieces	OTC monograph final	2010-06-11
humatin	ANDA	2025-11-13
madecassol	unapproved drug other	2019-10-08
paromomycin sulfate	ANDA	2017-11-07

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
cryptosporidiosis	—	D003457	A07.2
protozoan infections	—	D011528	B50-B64
amebiasis	EFO_0007144	D000562	A06

Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

A: Alimentary tract and metabolism drugs

— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents

— A07A: Intestinal antiinfectives

— A07AA: Antibiotics, intestinal

— A07AA06: Paromomycin

HCPCS

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Clinical

Clinical Trials

1249 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Infections	D007239	EFO_0000544	—	14	25	39	63	58	193
Communicable diseases	D003141	—	—	6	19	21	23	32	97
Hiv infections	D015658	EFO_0000764	B20	11	23	33	8	20	91
Healthy volunteers/patients	—	—	—	60	2	1	7	8	77
Covid-19	D000086382	—	U07.1	6	26	31	4	11	70
Helicobacter infections	D016481	EFO_1000961	—	—	5	17	23	13	56
Pneumonia	D011014	EFO_0003106	J18	1	7	18	13	16	52
Mycobacterium avium-intracellulare infection	D015270	EFO_0007386	—	1	8	9	5	10	32
Mycobacterium infections	D009164	—	A31.9	1	8	10	2	11	30
Lung diseases	D008171	EFO_0003818	J98.4	1	6	10	9	3	28

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Lymphoma	D008223	—	C85.9	9	19	9	—	3	37
Multiple myeloma	D009101	—	C90.0	3	20	4	—	—	25
Large b-cell lymphoma diffuse	D016403	—	C83.3	7	12	7	—	—	22
B-cell lymphoma	D016393	—	—	8	9	5	—	1	21
Plasma cell neoplasms	D054219	—	—	2	15	4	—	—	20
Leukemia	D007938	—	C95	5	9	1	—	2	16
Cutaneous leishmaniasis	D016773	—	B55.1	1	11	5	—	2	16
Falciparum malaria	D016778	EFO_0007444	B50	1	12	8	—	—	15
Pulmonary tuberculosis	D014397	EFO_1000049	A15	—	9	4	—	2	14
Coronavirus infections	D018352	EFO_0007224	B34.2	1	6	6	—	1	13

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Neoplasms	D009369	—	C80	9	7	—	—	2	16
Myeloid leukemia acute	D015470	—	C92.0	7	7	—	—	—	12
Myelodysplastic syndromes	D009190	—	D46	4	8	—	—	—	11
B-cell lymphoma marginal zone	D018442	—	C88.4	1	5	—	—	3	9
Precursor cell lymphoblastic leukemia-lymphoma	D054198	—	C91.0	1	6	—	—	1	7
Myeloid leukemia	D007951	—	C92	4	2	—	—	1	6
Squamous cell carcinoma of head and neck	D000077195	—	—	1	6	—	—	—	6
Chronic hepatitis b	D019694	EFO_0004239	B18.1	1	6	—	—	—	6
Cryptosporidiosis	D003457	—	A07.2	1	2	—	—	3	5
Bcr-abl positive chronic myelogenous leukemia	D015464	EFO_0000340	—	1	4	—	—	1	5

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Drug interactions	D004347	—	—	8	—	—	—	—	8
Bacterial eye infections	D015818	—	—	5	—	—	—	—	5
Long qt syndrome	D008133	HP_0001657	I45.81	1	—	—	—	2	3
Kidney diseases	D007674	EFO_0003086	N08	1	—	—	—	2	3
Myelomonocytic leukemia juvenile	D054429	—	C93.3	2	—	—	—	1	3
Chronic renal insufficiency	D051436	—	N18	1	—	—	—	1	2
Autoimmune diseases	D001327	EFO_0000540	M30-M36	2	—	—	—	—	2
Myelomonocytic leukemia acute	D015479	—	C92.5	1	—	—	—	1	2
Major depressive disorder	D003865	EFO_0003761	F22	1	—	—	—	1	2
Depressive disorder	D003866	EFO_1002014	F32.A	1	—	—	—	1	2

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Dermatitis	D003872	—	L30.9	—	—	—	—	3	3
Apnea	D001049	—	R06.81	—	—	—	—	3	3
Hypertension	D006973	EFO_0000537	I10	—	—	—	—	2	2
Hyperaldosteronism	D006929	—	E26	—	—	—	—	2	2
Drug-related side effects and adverse reactions	D064420	—	T88.7	—	—	—	—	2	2
Nutrition disorders	D009748	EFO_0001069	—	—	—	—	—	2	2
Opportunistic infections	D009894	—	—	—	—	—	—	2	2
Staphylococcal infections	D013203	—	A49.01	—	—	—	—	2	2
Staphylococcus aureus	D013211	NCBITaxon_1280	—	—	—	—	—	2	2
Hypercholesterolemia	D006937	—	—	—	—	—	—	2	2

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Paromomycin
INN	paromomycin
Description	Paromomycin sulfate is an aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. It has a role as an antibacterial drug, an antiprotozoal drug, an anthelminthic drug and an antiparasitic agent. It is functionally related to a paromomycin.
Classification	Small molecule
Drug class	antibiotics (Streptomyces strain)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O