Papaverine
Papaverine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| papaverine hydrochloride | unapproved drug other | 2025-02-11 |
Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03A: Drugs for functional gastrointestinal disorders
— A03AD: Papaverine and derivatives containing drugs for functional gastrointestinal disorders
— A03AD01: Papaverine
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04B: Urologicals
— G04BE: Drugs used in erectile dysfunction
— G04BE02: Papaverine
— G04BE52: Papaverine, combinations
HCPCS
Code | Description |
|---|---|
| J2440 | Injection, papaverine hcl, up to 60 mg |
Clinical
Clinical Trials
47 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | — | 1 | — | 1 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | — | — | 1 | — | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | — | — | 1 | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | — | — | 1 | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | — | — | 1 | — | 1 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | 1 | — | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | 1 | — | 1 |
| Virus diseases | D014777 | — | B34 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | 1 | — | — | 1 |
| Traumatic stress disorders | D040921 | — | — | — | — | 1 | — | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | — | 1 | — | — | 3 | 4 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 1 | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | — | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | 1 | 2 |
| Vasculogenic impotence | D018783 | EFO_1001234 | — | 1 | — | — | — | — | 1 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | — | — | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | — | — | — | — | 1 |
| Cognition disorders | D003072 | — | — | 1 | — | — | — | — | 1 |
| Neurocognitive disorders | D019965 | — | F09 | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Patellofemoral pain syndrome | D046788 | EFO_1001092 | — | — | — | — | — | 5 | 5 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | — | 5 | 5 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 3 | 3 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 3 | 3 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 3 | 3 |
| Oligospermia | D009845 | — | N46.1 | — | — | — | — | 2 | 2 |
| Peroneal neuropathies | D020427 | EFO_1001102 | G57.3 | — | — | — | — | 2 | 2 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | — | — | — | — | 1 | 1 |
| Penile neoplasms | D010412 | — | C60 | — | — | — | — | 1 | 1 |
| Joint diseases | D007592 | — | M12.9 | — | — | — | — | 1 | 1 |
Show 26 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Papaverine |
| INN | — |
| Description | Papaverine is a benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. It has a role as a vasodilator agent and an antispasmodic drug. It is a benzylisoquinoline alkaloid, a member of isoquinolines and a dimethoxybenzene. |
| Classification | Small molecule |
| Drug class | spasmolytic agents (papaverine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 58-74-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19224 |
| ChEBI ID | 28241 |
| PubChem CID | 4680 |
| DrugBank | DB01113 |
| UNII ID | — |
Target
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Variants
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Financial
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Estimated US medical usage
Papaverine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Tabular view
Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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512 adverse events reported
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