Papaverine
Papaverine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| papaverine hydrochloride | unapproved drug other | 2025-02-11 |
Indications
FDA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03A: Drugs for functional gastrointestinal disorders
— A03AD: Papaverine and derivatives containing drugs for functional gastrointestinal disorders
— A03AD01: Papaverine
G: Genito urinary system and sex hormones
— G04: Urologicals
— G04B: Urologicals
— G04BE: Drugs used in erectile dysfunction
— G04BE02: Papaverine
— G04BE52: Papaverine, combinations
HCPCS
Code | Description |
|---|---|
| J2440 | Injection, papaverine hcl, up to 60 mg |
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | — | 1 | — | 1 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | — | — | 1 | — | 1 |
| Dysmenorrhea | D004412 | — | N94.6 | — | — | — | 1 | — | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | — | — | — | 1 | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | — | — | 1 | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | — | — | 1 | — | 1 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | 1 | — | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | 1 | — | 1 |
| Virus diseases | D014777 | — | B34 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | 1 | — | — | 1 |
| Traumatic stress disorders | D040921 | — | — | — | — | 1 | — | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | 1 | — | — | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 1 | 1 | — | — | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | 1 | 1 | — | — | 1 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | 1 | 1 | — | — | 1 |
| Regional blood flow | D012039 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | 1 | — | — | 3 | 5 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | 1 | 2 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | 1 | — | — | 1 | 2 |
| Muscle cramp | D009120 | — | — | — | 1 | — | — | — | 1 |
| Spasm | D013035 | — | M62.83 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | — | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | 1 | 2 |
| Vasculogenic impotence | D018783 | EFO_1001234 | — | 1 | — | — | — | — | 1 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | — | — | — | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | — | — | — | — | 1 |
| Cognition disorders | D003072 | — | — | 1 | — | — | — | — | 1 |
| Neurocognitive disorders | D019965 | — | F09 | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Oligospermia | D009845 | — | N46.1 | — | — | — | — | 2 | 2 |
| Penile neoplasms | D010412 | — | C60 | — | — | — | — | 1 | 1 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 1 | 1 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Acute pain | D059787 | — | R52 | — | — | — | — | 1 | 1 |
| Labor pain | D048949 | — | — | — | — | — | — | 1 | 1 |
| Induced labor | D007751 | — | — | — | — | — | — | 1 | 1 |
| Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
| Azoospermia | D053713 | EFO_0000279 | N46.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Papaverine |
| INN | — |
| Description | Papaverine is a benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. It has a role as a vasodilator agent and an antispasmodic drug. It is a benzylisoquinoline alkaloid, a member of isoquinolines and a dimethoxybenzene. |
| Classification | Small molecule |
| Drug class | spasmolytic agents (papaverine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 58-74-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL19224 |
| ChEBI ID | 28241 |
| PubChem CID | 4680 |
| DrugBank | DB01113 |
| UNII ID | — |
Target
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Variants
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Financial
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Estimated US medical usage
Papaverine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Price per prescription (USD)
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Tabular view
Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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485 adverse events reported
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