Pancrelipase
Creon, Pancreaze, Pertzye, Viokace, Zenpep (pancrelipase) is an enzyme pharmaceutical. Pancrelipase was first approved as Cotazym on 1996-12-09. It is used to treat exocrine pancreatic insufficiency in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| digestive system diseases | D004066 |
Trade Name
FDA
EMA
Creon, Pancreaze, Pertzye, Viokace, Zenpep (discontinued: Cotazym)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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Clinical
Clinical Trials
208 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Exocrine pancreatic insufficiency | D010188 | — | K86.81 | 3 | 5 | 17 | 14 | 6 | 43 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 6 | 2 | 1 | 2 | 27 | 38 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 5 | 13 | 2 | 3 | 16 | 36 |
| Fibrosis | D005355 | — | — | — | 2 | 12 | 6 | 8 | 28 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 2 | 12 | 7 | 7 | 28 |
| Pancreatitis | D010195 | HP_0001733 | K85 | 6 | 3 | 4 | 6 | 6 | 24 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | 4 | 3 | 4 | 5 | 3 | 18 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | 5 | 6 |
| Pancreatic diseases | D010182 | — | K86.9 | — | — | — | 1 | 5 | 6 |
| Steatorrhea | D045602 | — | — | 1 | 1 | 3 | 1 | — | 6 |
Show 13 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 9 | 9 | 7 | — | 55 | 76 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | — | 1 | — | 2 | 3 |
| Malabsorption syndromes | D008286 | EFO_0009554 | K90 | — | 2 | 1 | — | — | 3 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | 1 | — | 2 | 3 |
| Pancreatectomy | D010180 | EFO_0002581 | — | — | — | 3 | — | — | 3 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | 1 | — | — | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | 1 | — | — | 1 |
| Child nutrition disorders | D015362 | — | — | — | 1 | 1 | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | 1 | — | — | 1 |
| Eructation | D004884 | — | R14.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | — | — | 1 | 5 | — | — | 4 | 9 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | 1 | — | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | 1 | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | 1 | 2 |
| Short bowel syndrome | D012778 | — | K90.82 | — | 1 | — | — | — | 1 |
| Cachexia | D002100 | HP_0004326 | R64 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic cyst | D010181 | HP_0001737 | K86.2 | 1 | — | — | — | 4 | 5 |
| Hypoglycemia | D007003 | HP_0001943 | E16.2 | 1 | — | — | — | 3 | 4 |
| Cysts | D003560 | — | — | 1 | — | — | — | 2 | 3 |
| Abdominal pain | D015746 | HP_0002027 | R10.9 | 1 | — | — | — | 1 | 2 |
| Graft pancreatitis | D055589 | — | — | 1 | — | — | — | — | 1 |
| Pancreaticojejunostomy | D010193 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperglycemia | D006943 | HP_0003074 | R73.9 | — | — | — | — | 3 | 3 |
| Gastrointestinal diseases | D005767 | — | — | — | — | — | — | 3 | 3 |
| Digestive system diseases | D004066 | HP_0011024 | K92.9 | — | — | — | — | 3 | 3 |
| Pancreatic fistula | D010185 | — | — | — | — | — | — | 2 | 2 |
| Fistula | D005402 | — | — | — | — | — | — | 2 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 2 | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | — | — | — | 1 | 1 |
| Kidney transplantation | D016030 | — | — | — | — | — | — | 1 | 1 |
| Organ transplantation | D016377 | — | — | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
Show 34 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pancrelipase |
| INN | — |
| Description | Pancreatic enzymes, also known as pancreases or pancrelipase and pancreatin, are commercial mixtures of amylase, lipase, protease and lactase. They are used to treat malabsorption syndrome due to certain pancreatic problems. These pancreatic problems may be due to cystic fibrosis, surgical removal of the pancreas, long term pancreatitis, pancreatic cancer, or MODY 5, among others. The preparation is taken by mouth.
|
| Classification | Enzyme |
| Drug class | enzymes |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108074 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00085 |
| UNII ID | — |
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Creon – Viatris
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Creon – AbbVie
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Zenpep – Allergan
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Zenpep – Warner Chilcott
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Pancreaze – Vivus
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Safety
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12,684 adverse events reported
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