Pamiparib
Pamiparib is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
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Clinical
Clinical Trials
36 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 2 | 1 | — | 2 | 11 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 7 | 1 | — | 1 | 9 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 2 | 7 | 1 | — | — | 8 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | — | 5 | — | — | — | 5 |
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | 2 | — | — | — | 4 |
| Recurrence | D012008 | — | — | 2 | 2 | — | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 2 | 1 | — | — | — | 2 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | — | 2 | — | — | — | 2 |
| Carcinosarcoma | D002296 | — | — | 1 | 2 | — | — | — | 2 |
| Mullerian mixed tumor | D018200 | — | — | 1 | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | — | 2 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancytopenia | D010198 | — | D61.81 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pamiparib |
| INN | pamiparib |
| Description | PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP).
|
| Classification | Small molecule |
| Drug class | poly-ADP-ribose polymerase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@]12CCCN1CC1=NNC(=O)c3cc(F)cc4[nH]c2c1c34 |
Identifiers
| PDB | — |
| CAS-ID | 1446261-44-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4112930 |
| ChEBI ID | — |
| PubChem CID | 135565554 |
| DrugBank | DB14769 |
| UNII ID | 8375F9S90C (ChemIDplus, GSRS) |
Target
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Safety
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Adverse Events
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