Palovarotene
Sohonos (palovarotene) is a small molecule pharmaceutical. Palovarotene was first approved as Sohonos on 2023-08-16. It is used to treat heterotopic ossification in the USA. The pharmaceutical is active against retinoic acid receptor gamma.
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EMA approval date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Sohonos
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| sohonos | New Drug Application | 2025-03-18 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| heterotopic ossification | — | D009999 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
PALOVAROTENE, SOHONOS, IPSEN | |||
| 2030-08-16 | ODE-439 | ||
| 2028-08-16 | NCE | ||
HCPCS
No data
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myositis ossificans | D009221 | — | M61.1 | — | — | 1 | — | 1 | 2 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dry eye syndromes | D015352 | — | H04.12 | 1 | — | — | — | — | 1 |
| Eye diseases | D005128 | EFO_0003966 | H44 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Palovarotene |
| INN | palovarotene |
| Description | Palovarotene is a stilbenoid. |
| Classification | Small molecule |
| Drug class | arotinoid derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21 |
Identifiers
| PDB | — |
| CAS-ID | 410528-02-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105648 |
| ChEBI ID | — |
| PubChem CID | 10295295 |
| DrugBank | DB05467 |
| UNII ID | 28K6I5M16G (ChemIDplus, GSRS) |
Target
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 460 documents
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Safety
Black-box Warning
Black-box warning for: Sohonos
Adverse Events
Top Adverse Reactions
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40 adverse events reported
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