Palifosfamide
Palifosfamide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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527 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 40 | 119 | 35 | 8 | 7 | 189 |
| Sarcoma | D012509 | — | — | 22 | 70 | 36 | 3 | 18 | 137 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 15 | 40 | 17 | 3 | 1 | 65 |
| B-cell lymphoma | D016393 | — | — | 19 | 36 | 8 | 1 | 2 | 55 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 18 | 33 | 5 | 1 | 2 | 51 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 8 | 29 | 7 | 1 | 2 | 40 |
| Leukemia | D007938 | — | C95 | 7 | 17 | 12 | 3 | 2 | 39 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 4 | 10 | 14 | 5 | 2 | 33 |
| T-cell lymphoma | D016399 | — | — | 6 | 17 | 2 | 4 | — | 27 |
| T-cell lymphoma peripheral | D016411 | — | — | 6 | 13 | 2 | 4 | — | 23 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 26 | 24 | 9 | — | 3 | 52 |
| Osteosarcoma | D012516 | — | — | 11 | 25 | 8 | — | 7 | 44 |
| Hodgkin disease | D006689 | — | C81 | 9 | 21 | 9 | — | 1 | 33 |
| Recurrence | D012008 | — | — | 9 | 17 | 3 | — | 1 | 26 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 3 | 9 | 6 | — | 5 | 23 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 8 | 15 | 5 | — | — | 22 |
| Rhabdomyosarcoma | D012208 | — | — | 3 | 13 | 5 | — | 2 | 21 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 7 | 9 | 4 | — | 2 | 20 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 7 | 7 | — | 2 | 17 |
| Carcinoma | D002277 | — | C80.0 | — | 11 | 2 | — | 1 | 14 |
Show 72 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 8 | — | — | — | 9 |
| Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | 2 | 7 | — | — | — | 8 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | 6 | — | — | — | 6 |
| Transitional cell carcinoma | D002295 | — | — | 2 | 5 | — | — | — | 6 |
| Mantle-cell lymphoma | D020522 | — | — | 4 | 5 | — | — | — | 6 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | 3 | — | — | 2 | 5 |
| Wilms tumor | D009396 | EFO_0000212 | — | 2 | 2 | — | — | 1 | 5 |
| Penile neoplasms | D010412 | — | C60 | — | 5 | — | — | — | 5 |
| Myeloid leukemia | D007951 | — | C92 | 2 | 2 | — | — | — | 4 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | 3 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinoblastoma | D012175 | — | — | 1 | — | — | — | 1 | 2 |
| Rhabdoid tumor | D018335 | — | — | 1 | — | — | — | 1 | 2 |
| Hepatoblastoma | D018197 | — | C22.2 | 1 | — | — | — | 1 | 2 |
| Intestinal diseases | D007410 | HP_0002242 | K63.9 | 1 | — | — | — | — | 1 |
| Thymoma | D013945 | — | — | 1 | — | — | — | — | 1 |
| Neuroepithelial neoplasms | D018302 | — | — | 1 | — | — | — | — | 1 |
| Hairy cell leukemia | D007943 | — | C91.4 | 1 | — | — | — | — | 1 |
| Intraocular lymphoma | D064090 | — | — | 1 | — | — | — | — | 1 |
| Large granular lymphocytic leukemia | D054066 | — | — | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary diseases | D010900 | — | E23.7 | — | — | — | — | 2 | 2 |
| Medulloblastoma | D008527 | — | — | — | — | — | — | 1 | 1 |
| Retinal neoplasms | D019572 | — | C69.2 | — | — | — | — | 1 | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 1 | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | — | — | — | — | 1 | 1 |
| Pituitary neoplasms | D010911 | — | — | — | — | — | — | 1 | 1 |
| Sex cord-gonadal stromal tumors | D018312 | EFO_1000052 | — | — | — | — | — | 1 | 1 |
| Pinealoma | D010871 | — | — | — | — | — | — | 1 | 1 |
| Sertoli-leydig cell tumor | D018310 | — | — | — | — | — | — | 1 | 1 |
| Nodular goiter | D006044 | EFO_1001062 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Palifosfamide |
| INN | palifosfamide |
| Description | Isophosphamide mustard is a phosphorodiamide. |
| Classification | Small molecule |
| Drug class | phosphoro-derivatives; isophosphoramide mustard derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=P(O)(NCCCl)NCCCl |
Identifiers
| PDB | — |
| CAS-ID | 31645-39-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL889 |
| ChEBI ID | 80566 |
| PubChem CID | 100427 |
| DrugBank | — |
| UNII ID | 6A4U6NN813 (ChemIDplus, GSRS) |
Target
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Safety
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