PINOMETOSTAT
Pinometostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone-lysine N-methyltransferase, H3 lysine-79 specific.
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Commercial
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | — | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PINOMETOSTAT |
| INN | pinometostat |
| Description | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol is a 5'-deoxyribonucleoside. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)N(C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 1380288-87-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3414626 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 8V9YR09EF3 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
DOT1L
DOT1L
Organism
Homo sapiens
Gene name
DOT1L
Gene synonyms
KIAA1814, KMT4
NCBI Gene ID
Protein name
histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein synonyms
DOT1 like histone H3K79 methyltransferase, DOT1-like histone methyltransferase, DOT1-like protein, DOT1-like, histone H3 methyltransferase, H3-K79-HMTase, Histone H3-K79 methyltransferase, histone methyltransferase DOT1L, Lysine N-methyltransferase 4
Uniprot ID
Mouse ortholog
Dot1l (208266)
histone-lysine N-methyltransferase, H3 lysine-79 specific (H9LAN6)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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