PEPINEMAB
Pepinemab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against semaphorin-4D.
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2Y
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FDA approval date
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Study first post date
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Completion date
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Commercial
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | 2 | 1 | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | 1 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | 1 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | 2 | 1 | — | — | — | 2 |
| Recurrence | D012008 | — | — | 2 | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 2 | — | — | — | — | 2 |
| Melanoma | D008545 | — | — | 2 | — | — | — | — | 2 |
| Cutaneous malignant melanoma | D000096142 | — | — | 2 | — | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Sclerosis | D012598 | — | — | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PEPINEMAB |
| INN | pepinemab |
| Description | Pepinemab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against semaphorin-4D. |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297884 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | BPZ4A29SYE (ChemIDplus, GSRS) |
Target
Agency Approved
SEMA4D
SEMA4D
Organism
Homo sapiens
Gene name
SEMA4D
Gene synonyms
C9orf164, CD100, SEMAJ
NCBI Gene ID
Protein name
semaphorin-4D
Protein synonyms
A8, BB18, CD100, GR3, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
Uniprot ID
Mouse ortholog
Sema4d (20354)
semaphorin-4D (Q6GTM9)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 206 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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18 adverse events reported
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