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AboutPricing
Drug ReportsOxytocin
Oxytocin
Oxytocin, Pitocin (oxytocin) is a protein pharmaceutical. Oxytocin was first approved as Pitocin on 1982-01-01. It is used to treat postpartum hemorrhage in the USA. The pharmaceutical is active against oxytocin receptor. In addition, it is known to target vasopressin V1b receptor, vasopressin V2 receptor, and vasopressin V1a receptor.
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5D
1M
3M
6M
YTD
1Y
2Y
5Y
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FDA approval date
EMA approval date
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Oxytocin, Pitocin (discontinued: Oxytocin, Syntocinon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oxytocin
Tradename
Company
Number
Date
Products
PITOCINEndoN-018261 RX1982-01-01
3 products, RLD, RS
OXYTOCINFresenius KabiN-018248 RX1982-01-01
3 products, RLD, RS
OXYTOCINHikma PharmaceuticalsN-018243 RX1982-01-01
2 products, RLD, RS
Show 5 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
oxytocinNew Drug Application2024-10-11
pitocinNew Drug Application2024-08-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
postpartum hemorrhage—D006473O72
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02A: Uterotonics
— G02AC: Ergot alkaloids and oxytocin incl. analogues, in combination
— G02AC01: Methylergometrine and oxytocin
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BB: Oxytocin and analogues
— H01BB02: Oxytocin
HCPCS
Code
Description
J2590
Injection, oxytocin, up to 10 units
Clinical
Clinical Trials
837 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemorrhageD006470MP_0001914R581617283081166
Postpartum hemorrhageD006473—O721314252373144
Healthy volunteers/patients———173114062
SchizophreniaD012559EFO_0000692F2099—21534
Induced laborD007751——24361934
Autistic disorderD001321HP_0000717F84.072031433
Autism spectrum disorderD000067877HP_0000729F84.071831330
Obstetric labor complicationsD007744——24221725
Cesarean sectionD002585——21341322
PregnancyD011247EFO_0002950Z33.11—221520
Show 67 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AlcoholismD000437EFO_0003829F10.16143——22
SyndromeD013577——395—316
Prader-willi syndromeD011218Orphanet_739Q87.11485—315
DepressionD003863—F33.9131—913
Alcohol drinkingD000428EFO_0004329—271——9
Pre-eclampsiaD011225EFO_0000668O141—2—58
Knee osteoarthritisD020370EFO_0004616M17—81——8
AtrophyD001284———62——7
Atrophic vaginitisD059268EFO_1001271——52——6
Cocaine-related disordersD019970—F14241—16
Show 16 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postpartum depressionD019052EFO_0007453F53.0—2——79
Depressive disorderD003866EFO_1002014F32.A12——69
Opioid-related disordersD009293EFO_0005611F1162———7
Diabetes mellitusD003920HP_0000819E08-E1312——47
Psychotic disordersD011618—F20.8141——37
Social cognitionD000083282——51———6
Postoperative hemorrhageD019106——11——45
DementiaD003704EFO_0003862F0313——15
Frontotemporal dementiaD057180HP_0002145G31.012——14
Primary progressive aphasiaD018888EFO_0009053G31.0112——14
Show 63 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Personality disordersD010554HP_0012075F60.61———67
Borderline personality disorderD001883HP_0012076F60.31———56
Embryo transferD004624——4————4
Social psychologyD011593——3————3
High-risk pregnancyD018566——1———23
Antisocial personality disorderD000987—F60.21———23
StrokeD020521EFO_0000712I63.91———12
EmotionsD004644——1———12
Parent-child relationsD010287——1———12
Fetal growth retardationD005317EFO_0000495—1———12
Show 25 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Placenta accretaD010921EFO_0007440O43.21————55
Breast feedingD001942——————55
Pathologic dilatationD004108——————33
Vaginal birth after cesareanD016064——————33
HypertensionD006973EFO_0000537I10————33
Gestational diabetesD016640HP_0009800O24.4————33
Morbid obesityD009767EFO_0001074—————33
InfertilityD007246HP_0000789—————22
PlacebosD010919——————22
Premature obstetric laborD007752—O60————22
Show 105 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOxytocin
INNoxytocin
Description
Oxytocin is a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour. It has a role as an oxytocic and a vasodilator agent. It is a peptide hormone and a heterodetic cyclic peptide.
Classification
Protein
Drug classoxytocin derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
Identifiers
PDB—
CAS-ID50-56-6
RxCUI—
ChEMBL IDCHEMBL395429
ChEBI ID7872
PubChem CID439302
DrugBankDB00107
UNII ID1JQS135EYN (ChemIDplus, GSRS)
Target
Agency Approved
OXTR
OXTR
Organism
Homo sapiens
Gene name
OXTR
Gene synonyms
NCBI Gene ID
5021
Protein name
oxytocin receptor
Protein synonyms
Uniprot ID
Q15071
Mouse ortholog
Oxtr (18430)
oxytocin receptor (P97926)
Alternate
AVPR1B
AVPR1B
AVPR2
AVPR2
AVPR1A
AVPR1A
Organism
Homo sapiens
Gene name
AVPR1B
Gene synonyms
AVPR3, VPR3
NCBI Gene ID
553
Protein name
vasopressin V1b receptor
Protein synonyms
Antidiuretic hormone receptor 1b, arginine vasopressin receptor 3, AVPR V1b, AVPR V3, pituitary vasopressin receptor 3, V1B receptor, Vasopressin V3 receptor
Uniprot ID
Q5TZ00
Mouse ortholog
Avpr1b (26361)
vasopressin V1b receptor (Q9WU02)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 50,102 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,070 adverse events reported
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