Oxytocin
Oxytocin, Pitocin (oxytocin) is a protein pharmaceutical. Oxytocin was first approved as Pitocin on 1982-01-01. It is used to treat postpartum hemorrhage in the USA. The pharmaceutical is active against oxytocin receptor. In addition, it is known to target vasopressin V1b receptor, vasopressin V2 receptor, and vasopressin V1a receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Oxytocin, Pitocin (discontinued: Oxytocin, Syntocinon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oxytocin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PITOCIN | Endo | N-018261 RX | 1982-01-01 | 3 products, RLD, RS |
| OXYTOCIN | Fresenius Kabi | N-018248 RX | 1982-01-01 | 3 products, RLD, RS |
| OXYTOCIN | Hikma Pharmaceuticals | N-018243 RX | 1982-01-01 | 2 products, RLD, RS |
Show 5 discontinued
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| postpartum hemorrhage | — | D006473 | O72 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02A: Uterotonics
— G02AC: Ergot alkaloids and oxytocin incl. analogues, in combination
— G02AC01: Methylergometrine and oxytocin
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BB: Oxytocin and analogues
— H01BB02: Oxytocin
HCPCS
Code | Description |
|---|---|
| J2590 | Injection, oxytocin, up to 10 units |
Clinical
Clinical Trials
876 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postpartum hemorrhage | D006473 | — | O72 | 12 | 15 | 23 | 22 | 75 | 143 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 6 | 12 | 15 | 16 | 46 | 93 |
| Healthy volunteers/patients | — | — | — | 17 | 4 | 1 | 1 | 42 | 65 |
| Induced labor | D007751 | — | — | 2 | 4 | 3 | 8 | 23 | 40 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 9 | 9 | — | 2 | 13 | 32 |
| Autism spectrum disorder | D000067877 | — | F84.0 | 7 | 18 | 3 | 1 | 3 | 30 |
| Obstetric labor complications | D007744 | — | — | 2 | 5 | 2 | 1 | 19 | 27 |
| Cesarean section | D002585 | — | — | 2 | 1 | 3 | 3 | 15 | 23 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 2 | 2 | 15 | 20 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 3 | 8 | 1 | 3 | 4 | 19 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | 8 | 16 | 1 | — | 3 | 26 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 6 | 14 | 3 | — | — | 22 |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | 4 | 8 | 4 | — | 3 | 14 |
| Depression | D003863 | — | F33.9 | 2 | 1 | 1 | — | 10 | 13 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | 3 | 5 | 1 | — | 2 | 10 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 8 | 1 | — | — | 8 |
| Syndrome | D013577 | — | — | — | 4 | 2 | — | 2 | 7 |
| Atrophic vaginitis | D059268 | EFO_1001271 | — | — | 5 | 2 | — | — | 6 |
| Cocaine-related disorders | D019970 | — | F14 | 2 | 4 | 1 | — | 1 | 6 |
| Atrophy | D001284 | — | — | — | 3 | 1 | — | — | 4 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postpartum depression | D019052 | EFO_0007453 | F53.0 | — | 2 | — | — | 8 | 10 |
| Psychotic disorders | D011618 | — | F20.81 | 4 | 1 | — | — | 3 | 7 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 6 | 1 | — | — | — | 6 |
| Social cognition | D000083282 | — | — | 5 | 1 | — | — | — | 6 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | 5 | 6 |
| Postoperative hemorrhage | D019106 | — | — | 1 | 1 | — | — | 4 | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | 4 | 5 |
| Alcohol drinking | D000428 | EFO_0004329 | — | 1 | 4 | — | — | — | 5 |
| Frontotemporal dementia | D057180 | — | G31.0 | 1 | 2 | — | — | 1 | 4 |
| Schizophrenia spectrum and other psychotic disorders | D019967 | — | — | 1 | 1 | — | — | 3 | 4 |
Show 71 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Borderline personality disorder | D001883 | — | F60.3 | 1 | — | — | — | 5 | 6 |
| Personality disorders | D010554 | — | F60.6 | 1 | — | — | — | 5 | 6 |
| Embryo transfer | D004624 | — | — | 4 | — | — | — | — | 4 |
| Social psychology | D011593 | — | — | 3 | — | — | — | — | 3 |
| Parent-child relations | D010287 | — | — | 1 | — | — | — | 2 | 3 |
| High-risk pregnancy | D018566 | — | — | 1 | — | — | — | 2 | 3 |
| Addictive behavior | D016739 | EFO_0004347 | — | 3 | — | — | — | — | 3 |
| Antisocial personality disorder | D000987 | — | F60.2 | 1 | — | — | — | 2 | 3 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | — | — | — | 1 | 2 |
| Emotions | D004644 | — | — | 1 | — | — | — | 1 | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Placenta accreta | D010921 | EFO_0007440 | O43.2 | — | — | — | — | 5 | 5 |
| Breast feeding | D001942 | — | — | — | — | — | — | 5 | 5 |
| Vaginal birth after cesarean | D016064 | — | — | — | — | — | — | 3 | 3 |
| Gestational diabetes | D016640 | — | O24.4 | — | — | — | — | 3 | 3 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | — | 2 | 2 |
| Placebos | D010919 | — | — | — | — | — | — | 2 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 2 | 2 |
| Endometritis | D004716 | EFO_1001312 | — | — | — | — | — | 2 | 2 |
| Chorioamnionitis | D002821 | — | O41.12 | — | — | — | — | 2 | 2 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
Show 118 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Oxytocin |
| INN | oxytocin |
| Description | Oxytocin is a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour. It has a role as an oxytocic and a vasodilator agent. It is a peptide hormone and a heterodetic cyclic peptide. |
| Classification | Protein |
| Drug class | oxytocin derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 50-56-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL395429 |
| ChEBI ID | 7872 |
| PubChem CID | 439302 |
| DrugBank | DB00107 |
| UNII ID | 1JQS135EYN (ChemIDplus, GSRS) |
Target
Alternate
AVPR1B
AVPR1B
AVPR2
AVPR2
AVPR1A
AVPR1A
Organism
Homo sapiens
Gene name
AVPR1B
Gene synonyms
AVPR3, VPR3
NCBI Gene ID
Protein name
vasopressin V1b receptor
Protein synonyms
Antidiuretic hormone receptor 1b, arginine vasopressin receptor 3, AVPR V1b, AVPR V3, pituitary vasopressin receptor 3, V1B receptor, Vasopressin V3 receptor
Uniprot ID
Mouse ortholog
Avpr1b (26361)
vasopressin V1b receptor (Q9WU02)
Variants
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Financial
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Trends
PubMed Central
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Safety
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Adverse Events
Top Adverse Reactions
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2,298 adverse events reported
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