Tradename | Company | Number | Date | Products |
---|---|---|---|---|
VISINE L.R. | Johnson & Johnson | N-019407 OTC | 1989-03-31 | 1 products, RLD, RS |
RHOFADE | Mayne Group | N-208552 RX | 2017-01-18 | 1 products, RLD, RS |
UPNEEQ | RVL Pharmaceuticals | N-212520 RX | 2020-07-08 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
KOVANAZE | St Renatus | N-208032 RX | 2016-06-29 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
mucinex | OTC monograph final | 2010-10-07 |
mucinex childrens stuffy nose | OTC monograph final | 2022-01-11 |
mucinex sinus-max | OTC monograph final | 2022-01-07 |
mucinex sinus-max pressure, pain and cough and mucinex sinus-max severe congestion relief clear and cool | C200263 | 2023-10-02 |
nasal decongestant | C200263 | 2024-01-01 |
vicks sinex | C200263 | 2023-10-16 |
vicks sinex severe | C200263 | 2023-10-16 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
common cold | EFO_0007214 | D003139 | J00 |
conjunctivitis | — | D003231 | H10 |
rhinitis | EFO_0008521 | D012220 | J31 |
sinusitis | EFO_0007486 | D012852 | J32 |
Expiration | Code | ||
---|---|---|---|
OXYMETAZOLINE HYDROCHLORIDE, UPNEEQ, RVL PHARMS | |||
2023-07-08 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Oxymetazoline Hydrochloride, Upneeq, Rvl Pharms | |||
10799481 | 2039-12-16 | U-2849 | |
10814001 | 2039-12-16 | DP | |
10898573 | 2039-12-16 | DP | |
10940138 | 2039-12-16 | U-2849 | |
11103482 | 2039-12-16 | DP | |
11311515 | 2039-12-16 | DP | |
11324722 | 2039-12-16 | U-2849 | |
11541036 | 2039-12-16 | DP | |
8357714 | 2031-08-26 | U-2849 | |
9867808 | 2031-08-26 | U-2849 | |
10912765 | 2031-08-26 | U-2849 | |
Oxymetazoline Hydrochloride, Rhofade, Mayne Pharma | |||
9974773 | 2035-06-11 | U-2306 | |
10335391 | 2035-06-11 | U-2567 | |
10751325 | 2035-06-11 | U-2921 | |
11517560 | 2035-06-11 | U-3494 | |
8883838 | 2031-12-01 | DP | |
7812049 | 2028-05-02 | U-1959 | |
8420688 | 2024-08-02 | U-1959 | |
8815929 | 2024-01-22 | U-1959 | |
Oxymetazoline Hydrochloride / Tetracaine Hydrochloride, Kovanaze, St Renatus | |||
8580282 | 2030-04-02 | DP | U-1876 |
9308191 | 2030-04-02 | DP | U-1876 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 119 | 1 | — | 2 | 8 | 129 |
Hypotension | D007022 | EFO_0005251 | I95 | 3 | 5 | 5 | 17 | 23 | 50 |
Asthma | D001249 | EFO_0000270 | J45 | 15 | 8 | 2 | 1 | 1 | 27 |
Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 9 | 6 | 4 | 2 | 1 | 22 |
Anesthesia | D000758 | — | — | 1 | 5 | 4 | 5 | 7 | 22 |
Spinal anesthesia | D000775 | — | — | — | 2 | 1 | 8 | 4 | 15 |
Cataract | D002386 | HP_0000518 | H26.9 | — | — | 3 | 5 | 5 | 13 |
Blood pressure | D001794 | EFO_0004325 | — | 2 | 1 | 1 | 2 | 6 | 11 |
Vasoconstriction | D014661 | — | — | 5 | — | — | 1 | 5 | 11 |
Allergic rhinitis | D065631 | — | J30.9 | 2 | 3 | 1 | 3 | 1 | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Presbyopia | D011305 | — | H52.4 | 3 | — | 1 | — | 2 | 6 |
Respiratory tract infections | D012141 | — | J06.9 | 1 | — | 4 | — | — | 5 |
Rhinitis | D012220 | EFO_0008521 | J31 | 1 | 1 | 2 | — | 1 | 5 |
Spinal cord injuries | D013119 | EFO_1001919 | — | 1 | 1 | 1 | — | 3 | 5 |
Cold temperature | D003080 | — | — | — | — | 3 | — | — | 3 |
Inflammation | D007249 | MP_0001845 | — | — | — | 3 | — | — | 3 |
Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | — | 1 | 3 |
Fecal incontinence | D005242 | — | R15 | 2 | 1 | 1 | — | — | 3 |
Erythema | D004890 | HP_0010783 | L53.9 | — | — | 3 | — | — | 3 |
Eye diseases | D005128 | EFO_0003966 | H44 | — | — | 2 | — | 1 | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Parkinson disease | D010300 | EFO_0002508 | G20 | 6 | 1 | — | — | 1 | 8 |
Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 1 | — | — | 2 | 5 |
Dental caries | D003731 | EFO_0003819 | K02 | — | 3 | — | — | — | 3 |
Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | — | 3 | — | — | — | 3 |
Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | — | 1 | 2 |
Microcirculation | D008833 | — | — | — | 1 | — | — | 1 | 2 |
Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | 1 | 2 |
Hypertriglyceridemia | D015228 | EFO_0004211 | — | 1 | 1 | — | — | — | 2 |
Vasovagal syncope | D019462 | — | R55 | 1 | 1 | — | — | — | 2 |
Regional blood flow | D012039 | — | — | — | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Therapeutic equivalency | D013810 | — | — | 9 | — | — | — | — | 9 |
Pharmacokinetics | D010599 | — | — | 8 | — | — | — | — | 8 |
Cardiovascular diseases | D002318 | HP_0001626 | — | 2 | — | — | — | 5 | 7 |
Biological availability | D001682 | — | — | 4 | — | — | — | — | 4 |
Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | — | — | — | 3 | 4 |
Hypertension | D006973 | EFO_0000537 | I10 | 2 | — | — | — | 1 | 3 |
Essential hypertension | D000075222 | — | I10 | 3 | — | — | — | — | 3 |
Orthostatic hypotension | D007024 | — | I95.1 | 2 | — | — | — | 1 | 3 |
Heart failure | D006333 | HP_0001635 | I50 | 2 | — | — | — | 1 | 3 |
Hypoxia | D000860 | HP_0012418 | R09.02 | 1 | — | — | — | 2 | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 3 | 3 |
Carotid endarterectomy | D016894 | — | — | — | — | — | — | 3 | 3 |
Overweight | D050177 | — | E66.3 | — | — | — | — | 2 | 2 |
Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 2 | 2 |
Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 2 | 2 |
Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 2 | 2 |
Sinusitis | D012852 | EFO_0007486 | J32 | — | — | — | — | 2 | 2 |
Neck pain | D019547 | HP_0030833 | M54.2 | — | — | — | — | 2 | 2 |
Autonomic dysreflexia | D020211 | EFO_1001762 | G90.4 | — | — | — | — | 2 | 2 |
Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 2 | 2 |
Drug common name | Oxymetazoline |
INN | oxymetazoline |
Description | Oxymetazoline is a member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. It has a role as an alpha-adrenergic agonist, a sympathomimetic agent, a nasal decongestant and a vasoconstrictor agent. It is a member of phenols, a carboxamidine and a member of imidazolines. It is a conjugate base of an oxymetazoline(1+). |
Classification | Small molecule |
Drug class | antihistamines/local vasoconstrictors (antazoline type) |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C(C)(C)C)c(O)c(C)c1CC1=NCCN1 |
PDB | — |
CAS-ID | 1491-59-4 |
RxCUI | — |
ChEMBL ID | CHEMBL762 |
ChEBI ID | 7862 |
PubChem CID | 4636 |
DrugBank | DB00935 |
UNII ID | 8VLN5B44ZY (ChemIDplus, GSRS) |