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Drug ReportsOxycodone
Oxycodone
/ Oxycodone, Codoxy, Combunox, Oxycet, Oxycodone, Oxycontin, Percocet, Percodan, Percodan-demi, Roxicodone, Roxiprin, Roxybond, Targiniq, Troxyca, Tylox, Xtampza (oxycodone) is a small molecule pharmaceutical. Oxycodone was first approved as Oxycodone and acetaminophen on 1982-01-01. It is used to treat postoperative pain in the USA.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Oxycodone, Oxycontin, Roxicodone, Roxybond, Xtampza (discontinued: Oxaydo, Oxycodone, Roxicodone)
Combinations
Oxycet, Oxycodone acetaminophen, Oxycodone aspirin, Percocet, Percodan (discontinued: Codoxy, Combunox, Oxycodone, Oxycodone acetaminophen, Oxycodone aspirin, Oxycodone aspirin (half-strength), Oxycodone ibuprofen, Percocet, Percodan, Roxicet, Roxilox, Roxiprin, Targiniq, Troxyca, Tylox, Xartemis)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
OXYCODONE HYDROCHLORIDEGenus LifesciencesN-200534 RX2010-10-20
1 products, RLD, RS
OXYCODONE HYDROCHLORIDEGenus LifesciencesN-200535 RX2010-10-20
2 products, RLD, RS
ROXYBONDProtega PharmaceuticalsN-209777 RX2017-04-20
4 products
OXYCONTINPurdue PharmaN-022272 RX2010-04-05
7 products, RLD
ROXICODONESPECGXN-021011 RX2000-08-31
3 products, RLD
Show 3 discontinued
Naltrexone hydrochloride
+
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
TROXYCA ERPfizerN-207621 DISCN2016-08-19
6 products
Hide discontinued
Naloxone hydrochloride
+
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
TARGINIQPurdue PharmaN-205777 DISCN2014-07-23
3 products, RLD
Hide discontinued
Acetaminophen
+
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
XARTEMIS XRMallinckrodtN-204031 DISCN2014-03-11
1 products, RLD
Hide discontinued
Ibuprofen
+
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
COMBUNOXForest LaboratoriesN-021378 DISCN2004-11-26
1 products, RLD
Hide discontinued
Oxycodone
Tradename
Company
Number
Date
Products
XTAMPZA ERCollegium PharmaceuticalN-208090 RX2016-04-26
5 products, RLD, RS
Aspirin
+
Oxycodone hydrochloride
Tradename
Company
Number
Date
Products
PERCODANEndoN-007337 RX2005-08-05
1 products, RLD, RS
Aspirin
+
Oxycodone hydrochloride
+
Oxycodone terephthalate
Tradename
Company
Number
Date
Products
PERCODAN-DEMIEndoN-007337 DISCN1982-01-01
1 products
PERCODANEndoN-007337 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
endocetANDA2024-08-27
endodanNDA authorized generic2011-05-23
nalocetANDA2024-08-06
oxaydoNew Drug Application2024-04-24
oxycodoneANDA2022-09-22
oxycodone and acetaminophenANDA2024-09-16
oxycodone and acetaminophen oxycodone hydrochlorideANDA2023-10-24
oxycodone and aspirinANDA2023-09-18
oxycodone hclNDA authorized generic2021-10-30
oxycodone hcl controlled-releaseNew Drug Application2010-01-14
Show 15 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
feverHP_0001945D005334R50.9
postoperative pain—D010149G89.18
alcoholismEFO_0003829D000437F10.1
opioid-related disordersEFO_0005611D009293F11
drug overdose—D062787—
juvenile arthritisEFO_1002007D001171M08
menorrhagiaEFO_0003945D008595N92.0
ankylosing spondylitisEFO_0003898D013167M45
rheumatoid arthritisEFO_0000685D001172M06.9
Show 9 more
Agency Specific
FDA
EMA
Expiration
Code
OXYCODONE HYDROCHLORIDE, OXYCODONE HYDROCHLORIDE, GENUS LIFESCIENCES
2024-07-21M-14
OXYCODONE HYDROCHLORIDE, OXYCODONE HYDROCHLORIDE, VISTAPHARM
2024-07-21M-14
Patent Expiration
Patent
Expires
Flag
FDA Information
Oxycodone, Xtampza Er, Collegium Pharm Inc
97375302036-09-02DPU-1556
99685982036-09-02DPU-1556
101886442036-09-02DPU-1556
106464852036-09-02DPU-1556
96820752030-12-10DPU-1556
100047292030-12-10DPU-1556
106680602030-12-10DPU-1556
87588132025-06-10U-1556
73994882025-03-24DP
77717072025-03-24DP
84499092025-03-24DP
85572912025-03-21DP
Acetaminophen / Oxycodone Hydrochloride, Xartemis Xr, Mallinckrodt Inc
86586312032-05-16DP
87418852032-05-16DPU-1499
89929752032-05-16DP
90503352032-05-16DP
94686362032-05-16U-1499
85976812030-12-21DP
89803192030-12-21DP
83774532029-11-19DPU-1499
83724322029-03-11DPU-1499
83944082029-03-11DP
86689292029-03-11U-1499
79768702027-06-01U-1498
Oxycodone Hydrochloride, Oxycontin, Purdue Pharma Lp
88949872030-03-29DP
88087412027-08-24U-1556
88949882027-08-24DP
94923892027-08-24DP
94923912027-08-24U-1556
94923922027-08-24DP
94923932027-08-24U-1556
97639332027-08-24DP
97704162027-08-24DP
97758082027-08-24DP
113049082027-08-24DP
113049092027-08-24U-1556
104074342025-03-30DP
106966842025-03-30DP
Oxycodone Hydrochloride, Roxybond, Protega Pharms
79556192028-08-12DP
103147882028-08-12DP
Naltrexone Hydrochloride / Oxycodone Hydrochloride, Troxyca Er, Pfizer
78159342027-12-12DP
86854432025-07-03U-1508
Naloxone Hydrochloride / Oxycodone Hydrochloride, Targiniq, Purdue Pharma Lp
90739332025-03-30DP
95229192025-03-30DS, DP
Oxycodone Hydrochloride, Oxaydo, Zyla
72019202025-03-16DP
94924432024-05-26DP
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02A: Opioid analgesics
— N02AA: Natural opium alkaloid analgesics
— N02AA05: Oxycodone
— N02AA55: Oxycodone and naloxone
— N02AA56: Oxycodone and naltrexone
— N02AJ: Opioids in combination with non-opioid analgesics
— N02AJ17: Oxycodone and paracetamol
— N02AJ18: Oxycodone and acetylsalicylic acid
— N02AJ19: Oxycodone and ibuprofen
HCPCS
No data
Clinical
Clinical Trials
777 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149—G89.1878346858175
PainD010146EFO_0003843R521420382729127
Healthy volunteers/patients———441—2147
Opioid-related disordersD009293EFO_0005611F111214—81042
Chronic painD059350HP_0012532—661013641
Back painD001416HP_0003418M5412227436
Low back painD017116HP_0003419M54.512197534
OsteoarthritisD010003EFO_0002506M15-M1917149334
Acute painD059787—R5257741033
Cancer painD000072716—G89.3—679527
Show 166 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnesthesiaD000758———11—78
Hip osteoarthritisD015207EFO_1000786M16——2—57
Neoplasm metastasisD009362EFO_0009708—1—2—14
Replacement arthroplasty kneeD019645——1—1—24
ArthralgiaD018771HP_0002829M25.5—13——4
Joint diseasesD007592HP_0003040M12.9——2—13
MucositisD052016EFO_1001898—1—1—13
ArthroplastyD001178————1—12
ObesityD009765EFO_0001073E66.9——1—12
Brachial plexus blockD065527————1—12
Show 31 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EmergenciesD004630———1——56
Lung neoplasmsD008175HP_0100526C34.9012——14
SyndromeD013577———1——23
Anesthesia and analgesiaD000760——22——13
AdenoidectomyD000233——22———2
LeiomyomaD007889HP_0000131D25—1——12
MyofibromaD047708———1——12
Nasopharyngeal carcinomaD000077274———1——12
Dental pinsD003772———1———1
Heroin dependenceD006556EFO_0004240——1———1
Show 19 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Obstetric labor complicationsD007744——1———34
Drug interactionsD004347——1———23
HypercapniaD006935——3————3
StomatitisD013280EFO_1001904K12.12———13
Cesarean sectionD002585——1———12
Colorectal neoplasmsD015179——1———12
Impacted toothD014095HP_0011079K01.11———12
Squamous cell carcinoma of head and neckD000077195——1———12
Anxiety disordersD001008EFO_0006788F41.11———12
Recreational drug useD000084783——2————2
Show 13 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Conduction anesthesiaD000765——————44
Heart failureD006333HP_0001635I50————33
Aortic dissectionD000784—I71.0————33
Thoracic surgical proceduresD019616——————33
LaparoscopyD010535——————33
HypertensionD006973EFO_0000537I10————22
InfectionsD007239EFO_0000544—————22
MenorrhagiaD008595EFO_0003945N92.0————22
Hemophilia aD006467EFO_0007267D66————22
PneumoniaD011014EFO_0003106—————22
Show 175 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOxycodone
INNoxycodone
Description
Oxycodone is a semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain. It has a role as an opioid analgesic, a mu-opioid receptor agonist and an antitussive. It is an organic heteropentacyclic compound and a semisynthetic derivative. It is functionally related to a thebaine. It is a conjugate base of an oxycodone(1+). It derives from a hydride of a morphinan.
Classification
Small molecule
Drug classOpioid
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
Identifiers
PDB—
CAS-ID76-42-6
RxCUI—
ChEMBL IDCHEMBL656
ChEBI ID7852
PubChem CID5284603
DrugBankDB00497
UNII IDCD35PMG570 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Xtampza – Collegium Pharmaceutical
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Oxaydo – Assertio Therapeutics
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Oxaydo – Zyla Life Sciences
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Tabular view
Estimated US medical usage
Oxycodone
+
Acetaminophen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Oxycodone
+
Aspirin
Total medical expenditures per year (USD, in millions)
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Oxycodone
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Ibuprofen
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Oxycodone
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 20,817 documents
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Safety
Black-box Warning
Black-box warning for: Endocet, Nalocet, Oxaydo, Oxycodone, Oxycodone and acetaminophen, Oxycodone and acetaminophen oxycodone hydrochloride, Oxycodone and aspirin, Oxycodone hcl, Oxycodone hcl controlled-release, Oxycodone hydrochloride, Oxycodone hydrochloride and acetaminophen, Oxycodone hydrochloride oral solution, Oxycodone/apap, Oxycontin, Percocet, Prolate, Roxicodone, Roxybond, Targiniq, Xtampza
Adverse Events
Top Adverse Reactions
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260,693 adverse events reported
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