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Drug ReportsOxiglutatione
Oxiglutatione
Bss, Navstel (oxiglutatione) is a small molecule pharmaceutical. Oxiglutatione was first approved as Bss plus on 1982-01-01. The pharmaceutical is active against glutathione reductase, mitochondrial.
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2Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Combinations
Bss (discontinued: Methotrexate, Navstel)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcium chloride
+
Dextrose
+
Magnesium chloride
+
Oxiglutatione
+
Potassium chloride
+
Sodium bicarbonate
+
Sodium chloride
+
Sodium phosphate
Tradename
Company
Number
Date
Products
NAVSTELAlcon ResearchN-022193 DISCN2008-07-24
1 products
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Calcium chloride
+
Dextrose
+
Glutathione disulfide
+
Magnesium chloride
+
Potassium chloride
+
Sodium bicarbonate
+
Sodium chloride
+
Sodium phosphate
Tradename
Company
Number
Date
Products
BSS PLUSAlcon ResearchN-018469 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
jylamvoNew Drug Application2025-04-28
methotrexateANDA2025-07-30
methotrexate sodiumANDA2024-03-01
otrexupNew Drug Application2025-01-31
rasuvoNew Drug Application2024-12-06
trexallANDA2021-04-30
xatmepNew Drug Application2022-06-28
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2252 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ArthritisD001168EFO_0005856M05-M147323323113194732
Rheumatoid arthritisD001172EFO_0000685M06.96922721212481684
LeukemiaD007938—C951002701122139477
LymphomaD008223—C85.970220591132349
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.065179892131344
Lymphoid leukemiaD007945—C9158153681823285
Non-hodgkin lymphomaD008228—C85.926703027118
Graft vs host diseaseD006086—D89.811753204687
SyndromeD013577——244992881
PsoriasisD011565EFO_0000676L405513233174
Show 119 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190—D46307019—7111
Myeloid leukemia acuteD015470—C92.0284922—494
Myeloid leukemiaD007951—C92255217—491
PreleukemiaD011289——255414—687
Breast neoplasmsD001943EFO_0003869C5062932—872
NeoplasmsD009369—C8016388—1165
Myeloproliferative disordersD009196—D47.110404—451
Multiple myelomaD009101—C90.012301—441
Hematologic neoplasmsD019337——16284—240
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—4297—240
Show 109 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Plasma cell neoplasmsD054219——621——428
PlasmacytomaD010954—C90.3418——423
Myeloid leukemia chronic-phaseD015466——216———16
Blast crisisD001752——214———14
Myeloid leukemia accelerated phaseD015465——113———13
Healthy volunteers/patients———111——113
Primary myelofibrosisD055728—D47.427——211
Lymphoproliferative disordersD008232Orphanet_2442D47.917——210
Neurotoxicity syndromesD020258—G9224——49
Invasive hydatidiform moleD002820—D39.224——17
Show 130 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Retinal diseasesD012164—H35.91———12
MelanomaD008545——2————2
PharmacokineticsD010599——2————2
Drug interactionsD004347——2————2
Male breast neoplasmsD018567——1————1
HeadacheD006261—R511————1
Neck painD019547—M54.21————1
Sleep wake disordersD012893—G471————1
Plasma cell leukemiaD007952—C90.11————1
Chronic progressive multiple sclerosisD020528EFO_0003840—1————1
Show 19 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17————33
Skin diseasesD012871—L00-L99————33
Papillomavirus infectionsD030361——————22
Rheumatic feverD012213EFO_1001160I00-I02————22
Diabetes mellitusD003920EFO_0000400E08-E13————22
Chediak-higashi syndromeD002609Orphanet_167D72.0————22
Localized sclerodermaD012594EFO_1001361L94.0————11
Respiratory tract infectionsD012141—J06.9————11
PapillomaviridaeD027383——————11
PapillomaD010212——————11
Show 83 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameOxiglutatione
INNoxiglutatione
Description
Glutathione disulfide (GSSG) is a disulfide derived from two glutathione molecules.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O
Identifiers
PDB—
CAS-ID27025-41-8
RxCUI—
ChEMBL IDCHEMBL1372
ChEBI ID17858
PubChem CID11215652
DrugBankDB03310
UNII IDULW86O013H (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GSTM2
GSTM2
Organism
Homo sapiens
Gene name
GSTM2
Gene synonyms
GST4
NCBI Gene ID
2946
Protein name
glutathione S-transferase Mu 2
Protein synonyms
epididymis secretory sperm binding protein, glutathione S-alkyltransferase M2, glutathione S-aralkyltransferase M2, glutathione S-aryltransferase M2, glutathione S-transferase 4, glutathione S-transferase M1, glutathione S-transferase M2 (muscle), glutathione S-transferase mu 2 (muscle), GST class-mu 2, GST, muscle, GSTM2-2, S-(hydroxyalkyl)glutathione lyase M2
Uniprot ID
Q8WWE1
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Methotrexate – Pfizer
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Otrexup – Assertio Therapeutics
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,983 documents
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Safety
Black-box Warning
Black-box warning for: Jylamvo, Methotrexate, Methotrexate sodium, Otrexup, Rasuvo, Trexall, Xatmep
Adverse Events
Top Adverse Reactions
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253 adverse events reported
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