Oxacillin
Bactocill, Oxacillin (oxacillin) is a small molecule pharmaceutical. Oxacillin was first approved as Prostaphlin on 1982-01-01. It is used to treat bacterial endocarditis, bacterial infections, bacterial meningitis, cellulitis, and osteomyelitis amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Bactocill, Oxacillin (discontinued: Bactocill, Oxacillin, Prostaphlin)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| oxacillin | ANDA | 2025-08-13 |
| oxacillin oxacillin | ANDA | 2025-08-13 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J2700 | Injection, oxacillin sodium, up to 250 mg |
Clinical
Clinical Trials
58 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 1 | 3 | 3 | 6 | 13 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 2 | 3 | 4 | 3 | 12 |
| Staphylococcal infections | D013203 | — | A49.01 | — | 1 | 3 | 4 | 3 | 11 |
| Communicable diseases | D003141 | — | — | — | 1 | 2 | 3 | 2 | 8 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 2 | 1 | 4 | 1 | 8 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | 1 | 2 | — | 5 |
| Wound infection | D014946 | — | — | — | 2 | — | 2 | — | 4 |
| Abscess | D000038 | EFO_0003030 | — | — | 2 | — | 2 | — | 4 |
| Infectious skin diseases | D012874 | — | — | — | — | 2 | 1 | — | 3 |
| Infectious arthritis | D001170 | EFO_1001351 | M00 | — | 1 | — | 2 | — | 3 |
Show 19 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | 1 | — | 2 | — | 2 | 5 |
| Gram-positive bacterial infections | D016908 | — | — | — | 3 | 1 | — | — | 4 |
| Methicillin-resistant staphylococcus aureus | D055624 | — | — | — | — | 2 | — | — | 2 |
| Mastitis | D008413 | EFO_1001034 | N61 | — | 1 | 1 | — | 1 | 2 |
| Staphylococcal skin infections | D013207 | EFO_1001849 | L00 | — | — | 1 | — | — | 1 |
| Bacterial skin diseases | D017192 | — | — | — | — | 1 | — | — | 1 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | 1 | — | — | 1 |
| Disease susceptibility | D004198 | — | — | — | — | 1 | — | — | 1 |
| Staphylococcus | D013210 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | 1 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | — | — | — | — | 1 |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | — | 1 | 1 |
| Neutropenia | D009503 | — | D70 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Fever | D005334 | — | R50.9 | — | — | — | — | 1 | 1 |
| Febrile neutropenia | D064147 | — | — | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 1 | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | — | 1 | 1 |
| Surgical wound infection | D013530 | — | — | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Oxacillin |
| INN | oxacillin |
| Description | Oxacillin is a penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta. It has a role as an antibacterial agent and an antibacterial drug. It is a conjugate acid of an oxacillin(1-). |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1onc(-c2ccccc2)c1C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 66-79-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL819 |
| ChEBI ID | 7809 |
| PubChem CID | 6196 |
| DrugBank | DB00713 |
| UNII ID | UH95VD7V76 (ChemIDplus, GSRS) |
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Estimated US medical usage
Oxacillin
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Trends
PubMed Central
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Additional graphs summarizing 18,861 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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4,668 adverse events reported
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