Odronextamab
Odronextamab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target B-lymphocyte antigen CD20.
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Commercial
No data
Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Follicular lymphoma | D008224 | — | C82 | 1 | 3 | 3 | — | 2 | 9 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 3 | 1 | — | 2 | 7 |
| B-cell lymphoma | D016393 | — | — | — | 3 | 3 | — | 2 | 7 |
| Lymphoma | D008223 | — | C85.9 | — | 2 | 3 | — | 3 | 7 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 2 | 2 | — | 1 | 6 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | — | 1 | 1 | — | — | 2 |
| Recurrence | D012008 | — | — | 1 | — | 1 | — | — | 2 |
| Hodgkin disease | D006689 | — | C81 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mantle-cell lymphoma | D020522 | — | C83.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | 1 | — | — | — | — | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Odronextamab |
| INN | odronextamab |
| Description | Odronextamab (REGN1979) is a CD20 x CD3 bispecific monoclonal antibody that is developed by Regeneron Pharmaceuticals for B-cell non-Hodgkin lymphoma.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4298084 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB16684 |
| UNII ID | 8R5CM46UIO (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
MS4A1
MS4A1
Organism
Homo sapiens
Gene name
MS4A1
Gene synonyms
CD20
NCBI Gene ID
Protein name
B-lymphocyte antigen CD20
Protein synonyms
B-lymphocyte cell-surface antigen B1, B-lymphocyte surface antigen B1, Bp35, CD20, CD20 antigen, CD20 receptor, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, membrane-spanning 4-domains, subfamily A, member 1
Uniprot ID
Mouse ortholog
Ms4a1 (12482)
B-lymphocyte antigen CD20 (P19437)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 378 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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19 adverse events reported
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