Odanacatib
Odanacatib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cathepsin K. In addition, it is known to target cathepsin Z and cathepsin S.
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Commercial
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Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 6 | 3 | 5 | — | — | 14 |
| Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | — | 1 | 2 | — | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone diseases | D001847 | — | M89.9 | — | 1 | — | — | — | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver failure | D017093 | HP_0001399 | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Odanacatib |
| INN | odanacatib |
| Description | Odanacatib (INN; codenamed MK-0822) is an investigational treatment for osteoporosis and bone metastasis. It is an inhibitor of cathepsin K, an enzyme involved in bone resorption.
|
| Classification | Small molecule |
| Drug class | cathespin inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(F)C[C@H](N[C@@H](c1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(F)(F)F)C(=O)NC1(C#N)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 603139-12-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL481611 |
| ChEBI ID | — |
| PubChem CID | 10152654 |
| DrugBank | — |
| UNII ID | N673F6W2VH (ChemIDplus, GSRS) |
Target
Alternate
CTSZ
CTSZ
CTSS
CTSS
Organism
Homo sapiens
Gene name
CTSZ
Gene synonyms
NCBI Gene ID
Protein name
cathepsin Z
Protein synonyms
carboxypeptidase LB, cathepsin B2, cathepsin IV, Cathepsin P, Cathepsin X, cathepsin Y, cathepsin Z1, cysteine-type carboxypeptidase, lysosomal carboxypeptidase B, preprocathepsin P
Uniprot ID
Mouse ortholog
Ctsz (64138)
cathepsin Z (Q9WUU7)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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