Triapine
Triapine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
240 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Whooping cough | D014917 | EFO_0000650 | A37 | — | — | 2 | 1 | 1 | 4 |
| Diphtheria | D004165 | EFO_0005549 | A36 | — | — | 2 | 1 | — | 3 |
| Poliomyelitis | D011051 | EFO_0007450 | A80 | — | — | 2 | 1 | — | 3 |
| Tetanus | D013742 | EFO_0005593 | A35 | — | — | 1 | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis b | D006509 | — | — | — | — | 2 | — | — | 2 |
| Hepatitis | D006505 | — | K75.9 | — | — | 2 | — | — | 2 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | — | 1 | — | — | 1 |
| Haemophilus infections | D006192 | EFO_1001127 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Triapine |
| INN | — |
| Description | 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, also called Triapine) is substance of interest for the treatment of cancer. It is a thiosemicarbazone derivative of 3-aminopyridine-2-carboxaldehyde. It presents an N-N-S array of donor sites that strongly bind iron, robbing iron-containing enzymes of their prosthetic group.
|
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=S)N/N=C/c1ncccc1N |
Identifiers
| PDB | — |
| CAS-ID | 143621-35-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL231616 |
| ChEBI ID | — |
| PubChem CID | 9571836 |
| DrugBank | — |
| UNII ID | — |
Target
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Variants
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Financial
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Safety
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Adverse Events
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