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Drug ReportsOcx-0191
Triapine
Triapine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Financial
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Whooping coughD014917EFO_0000650A372—21510
PyelonephritisD011704EFO_1001141N10-N16——71—8
PruritusD011537—L29——5117
Squamous cell carcinoma of head and neckD000077195——1311—6
DiphtheriaD004165EFO_0005549A361—21—4
Parkinson diseaseD010300EFO_0002508G20——1124
Bone fracturesD050723EFO_0003931T14.8———134
MalariaD008288EFO_0001068B541——2—3
TetanusD013742EFO_0005593A351—11—3
Chronic painD059350—————123
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C951071——16
Type 1 diabetes mellitusD003922EFO_0001359E10111—1114
NeoplasmsD009369—C80821—212
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—451——10
Myeloid leukemiaD007951—C92451——10
InfectionsD007239EFO_0000544—1—7—19
Diabetes mellitusD003920EFO_0000400E08-E13——1—89
CarcinomaD002277—C80.0231—17
Urinary tract infectionsD014552EFO_0003103N39.0——7——7
AdenocarcinomaD000230——231—17
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289——46——19
Lung neoplasmsD008175—C34.9046———8
RecurrenceD012008——53———8
Myeloproliferative disordersD009196—D47.143———5
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.031———4
Myelodysplastic syndromesD009190—D4632———4
SyndromeD013577——31——14
Myeloid leukemia accelerated phaseD015465——12———3
Blast crisisD001752——12———3
LymphomaD008223—C85.922———3
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PeriodontitisD010518EFO_0000649K05.31———23
Periapical periodontitisD010485EFO_1001391K04.51———23
Myelodysplastic-myeloproliferative diseasesD054437——2————2
Hiv infectionsD015658EFO_0000764B202————2
Gene rearrangementD015321——1————1
TrismusD014313——1————1
TetanyD013746—P71.31————1
Neoplasm metastasisD009362EFO_0009708—1————1
Hematologic neoplasmsD019337——1————1
Acquired immunodeficiency syndromeD000163EFO_0000765B201————1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoarthritisD010003EFO_0002506M15-M19————88
Knee osteoarthritisD020370EFO_0004616M17————55
Anxiety disordersD001008EFO_0006788F41.1————33
Healthy volunteers/patients———————33
RadiculopathyD011843—M54.1————33
BursitisD002062EFO_1000941M71.9————33
Intervertebral disc degenerationD055959——————22
Plantar fasciitisD036981EFO_1001909M72.2————22
FasciitisD005208HP_0100537M72.9————22
Sprains and strainsD013180——————22
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameTriapine
INN—
Description
3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, also called Triapine) is substance of interest for the treatment of cancer. It is a thiosemicarbazone derivative of 3-aminopyridine-2-carboxaldehyde. It presents an N-N-S array of donor sites that strongly bind iron, robbing iron-containing enzymes of their prosthetic group.
Classification
Small molecule
Drug classtricyclic compounds
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Structure (InChI/SMILES or Protein Sequence)
NC(=S)N/N=C/c1ncccc1N
Identifiers
PDB—
CAS-ID143621-35-6
RxCUI—
ChEMBL IDCHEMBL231616
ChEBI ID—
PubChem CID9571836
DrugBank—
UNII ID—
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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