Sandostatin, Mycapssa(octreotide)
Mycapssa, Sandostatin (octreotide) is a protein pharmaceutical. Octreotide was first approved as Sandostatin on 1988-10-21. It is used to treat acromegaly, adenoma, diarrhea, pancreatic neoplasms, and pituitary neoplasms in the USA. It has been approved in Europe to treat acromegaly. The pharmaceutical is active against somatostatin receptor type 2. In addition, it is known to target somatostatin receptor type 3 and somatostatin receptor type 5.
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Commercial
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Mycapssa, Sandostatin (generic drugs available since 2005-03-28)
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Indications
FDA
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acromegaly | — | D000172 | — |
| adenoma | — | D000236 | — |
| diarrhea | HP_0002014 | D003967 | R19.7 |
| pancreatic neoplasms | EFO_0003860 | D010190 | C25 |
| pituitary neoplasms | — | D010911 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
OCTREOTIDE ACETATE, MYCAPSSA, AMRYT | |||
| 2023-06-26 | NP | ||
Patent Expiration
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01C: Hypothalamic hormones
— H01CB: Somatostatin and analogues
— H01CB02: Octreotide
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09I: Tumour detection radiopharmaceuticals
— V09IA: Technetium (99mtc) compounds
— V09IA07: Technetium (99mtc) hynic-octreotide
Clinical
Clinical Trials
290 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acromegaly | D000172 | — | — | 5 | 11 | 16 | 17 | 9 | 57 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 10 | 24 | 10 | 3 | 7 | 50 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 3 | 1 | 4 | 4 | 11 |
| Neoplasms | D009369 | — | C80 | 2 | 5 | 3 | 2 | — | 11 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | 2 | 3 | 1 | 3 | 9 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 1 | — | 3 | 3 | 9 |
| Hepatorenal syndrome | D006530 | — | K76.7 | — | 4 | 2 | 1 | 2 | 7 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | 1 | 1 | — | 3 | 1 | 5 |
| Congenital hyperinsulinism | D044903 | — | — | 1 | 1 | — | 1 | — | 3 |
| Ascites | D001201 | HP_0001541 | R18 | — | 2 | 1 | 1 | — | 3 |
Show 9 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoid tumor | D002276 | — | D3A.00 | 4 | 5 | 4 | — | — | 11 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 5 | 1 | — | 1 | 8 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 3 | 1 | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 2 | — | 2 | 5 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 2 | 3 | — | 1 | 5 |
| Colorectal neoplasms | D015179 | — | — | — | 1 | 4 | — | — | 5 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 2 | 3 | — | 1 | 5 |
| Gastro-enteropancreatic neuroendocrine tumor | — | — | — | 1 | — | 3 | — | — | 4 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | 4 | — | — | 4 |
| Prader-willi syndrome | D011218 | Orphanet_739 | Q87.11 | — | — | 1 | — | 2 | 3 |
Show 20 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuroendocrine carcinoma | D018278 | — | — | 1 | 6 | — | — | — | 7 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 3 | 6 | — | — | — | 7 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | 2 | 3 | — | — | 1 | 6 |
| Medulloblastoma | D008527 | — | — | 1 | 4 | — | — | 1 | 5 |
| Islet cell adenoma | D007516 | EFO_0007331 | D13.7 | 2 | 3 | — | — | — | 5 |
| Esophageal neoplasms | D004938 | — | C15 | — | 1 | — | — | 4 | 5 |
| Pheochromocytoma | D010673 | — | — | 2 | 2 | — | — | — | 4 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | — | — | 2 | 4 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | 1 | — | — | 2 | 3 |
| Paraganglioma | D010235 | — | — | 2 | 2 | — | — | — | 3 |
Show 34 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Insulin resistance | D007333 | HP_0000855 | E88.819 | 3 | — | — | — | 2 | 5 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 2 | — | — | — | 1 | 3 |
| Central nervous system neoplasms | D016543 | — | — | 2 | — | — | — | — | 2 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 2 | — | — | — | — | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Von hippel-lindau disease | D006623 | — | Q85.83 | 1 | — | — | — | — | 1 |
| Multiple endocrine neoplasia type 1 | D018761 | — | E31.21 | 1 | — | — | — | — | 1 |
| Merkel cell carcinoma | D015266 | EFO_1001471 | C4A | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 2 | 2 |
| Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | — | — | 2 | 2 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | — | 1 | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | — | 1 | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | — | — | — | 1 | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | — | — | — | 1 | 1 |
| Gliosarcoma | D018316 | — | — | — | — | — | — | 1 | 1 |
| Acoustic neuroma | D009464 | HP_0009588 | — | — | — | — | — | 1 | 1 |
Show 24 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Octreotide |
| INN | octreotide |
| Description | Octreotide, sold under the brand name Sandostatin among others, is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. It was first synthesized in 1979 by the chemist Wilfried Bauer, and binds predominantly to the somatostatin receptors SSTR2 and SSTR5.
|
| Classification | Protein |
| Drug class | peptides: inhibition of growth hormone release |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O |
Identifiers
| PDB | — |
| CAS-ID | 83150-76-9 |
| RxCUI | 7617 |
| ChEMBL ID | CHEMBL1680 |
| ChEBI ID | — |
| PubChem CID | 448601 |
| DrugBank | DB00104 |
| UNII ID | RWM8CCW8GP (ChemIDplus, GSRS) |
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Mycapssa – Amryt Pharma
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Sandostatin – Novartis
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Octreotide
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Safety
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30,361 adverse events reported
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