Obicetrapib
Obicetrapib is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
27 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dyslipidemias | D050171 | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Obicetrapib |
| INN | obicetrapib |
| Description | Obicetrapib is an experimental CETP inhibitor that is intended to treat dyslipidemia. In a clinical trial, as an add-on to statins, it decreased "LDL-C concentration (by up to 51%; P < 0.0001), the primary trial outcome. As compared with placebo, obicetrapib treatment also significantly (P < 0.0001) decreased apolipoprotein B (by up to 30%) and non-high-density lipoprotein cholesterol (non-HDL-C) concentration (by up to 44%), and significantly (P < 0.0001) increased HDL-C concentration (by up to 165%; the secondary trial outcomes)". As of 2023, it is in a Phase III trial.
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| Classification | Small molecule |
| Drug class | cholesterol ester transfer protein inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(OCCCC(=O)O)cn2)C[C@H]1CC |
Identifiers
| PDB | — |
| CAS-ID | 866399-87-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3785197 |
| ChEBI ID | — |
| PubChem CID | 11498596 |
| DrugBank | DB14890 |
| UNII ID | 8O74K609HN (ChemIDplus, GSRS) |
Target
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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