Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Dyslipidemias | D050171 | — | — | 2 | — | — | — | — | 2 |
Drug common name | Obicetrapib |
INN | obicetrapib |
Description | Obicetrapib is an experimental CETP inhibitor that is intended to treat dyslipidemia. In a clinical trial, as an add-on to statins, it decreased "LDL-C concentration (by up to 51%; P < 0.0001), the primary trial outcome. As compared with placebo, obicetrapib treatment also significantly (P < 0.0001) decreased apolipoprotein B (by up to 30%) and non-high-density lipoprotein cholesterol (non-HDL-C) concentration (by up to 44%), and significantly (P < 0.0001) increased HDL-C concentration (by up to 165%; the secondary trial outcomes)". As of 2023, it is in a Phase III trial.
|
Classification | Small molecule |
Drug class | cholesterol ester transfer protein inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(OCCCC(=O)O)cn2)C[C@H]1CC |
PDB | — |
CAS-ID | 866399-87-3 |
RxCUI | — |
ChEMBL ID | CHEMBL3785197 |
ChEBI ID | — |
PubChem CID | 11498596 |
DrugBank | DB14890 |
UNII ID | 8O74K609HN (ChemIDplus, GSRS) |