Obatoclax
Obatoclax is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target apoptosis regulator Bcl-2, induced myeloid leukemia cell differentiation protein Mcl-1, and bcl-2-like protein 1.
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Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
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Epidemiology
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Drug
General
| Drug common name | Obatoclax |
| INN | obatoclax |
| Description | Obatoclax mesylate, also known as GX15-070, is an experimental drug for the treatment of various types of cancer. It was discovered by Gemin X, which was acquired by Cephalon, which has since been acquired by Teva Pharmaceuticals. Several Phase II clinical trials were completed that investigated use of obatoclax in the treatment of leukemia, lymphoma, myelofibrosis, and mastocytosis.
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| Classification | Small molecule |
| Drug class | bcl-2 (B-cell lymphoma 2) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC1=CC(c2cc3ccccc3[nH]2)=N/C1=C\c1[nH]c(C)cc1C |
Identifiers
| PDB | — |
| CAS-ID | 803712-67-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL408194 |
| ChEBI ID | — |
| PubChem CID | 11404337 |
| DrugBank | — |
| UNII ID | QN4128B52A (ChemIDplus, GSRS) |
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