ONAMETOSTAT
Onametostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein arginine N-methyltransferase 5.
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Events Timeline
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YTD
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2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | — | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | — | — | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ONAMETOSTAT |
| INN | onametostat |
| Description | Onametostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein arginine N-methyltransferase 5. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2cc(CC[C@H]3C[C@@H](n4ccc5c(N)ncnc54)[C@H](O)[C@@H]3O)ccc2cc1Br |
Identifiers
| PDB | — |
| CAS-ID | 2086772-26-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4249337 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | N8VKI8FPW0 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PRMT5
PRMT5
Organism
Homo sapiens
Gene name
PRMT5
Gene synonyms
HRMT1L5, IBP72, JBP1, SKB1
NCBI Gene ID
Protein name
protein arginine N-methyltransferase 5
Protein synonyms
72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, HMT1 hnRNP methyltransferase-like 5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs
Uniprot ID
Mouse ortholog
Prmt5 (27374)
protein arginine N-methyltransferase 5 (Q9QZS9)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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