ONAMETOSTAT
Onametostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein arginine N-methyltransferase 5.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ONAMETOSTAT |
| INN | onametostat |
| Description | Onametostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target protein arginine N-methyltransferase 5. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2cc(CC[C@H]3C[C@@H](n4ccc5c(N)ncnc54)[C@H](O)[C@@H]3O)ccc2cc1Br |
Identifiers
| PDB | — |
| CAS-ID | 2086772-26-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4249337 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | N8VKI8FPW0 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PRMT5
PRMT5
Organism
Homo sapiens
Gene name
PRMT5
Gene synonyms
HRMT1L5, IBP72, JBP1, SKB1
NCBI Gene ID
Protein name
protein arginine N-methyltransferase 5
Protein synonyms
72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, HMT1 hnRNP methyltransferase-like 5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs
Uniprot ID
Mouse ortholog
Prmt5 (27374)
protein arginine N-methyltransferase 5 (Q9QZS9)
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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