OLORINAB
Olorinab is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against cannabinoid receptor 2. In addition, it is known to target cannabinoid receptor 1.
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Drug
General
| Drug common name | OLORINAB |
| INN | olorinab |
| Description | Olorinab (APD371) is a drug being developed by Arena Pharmaceuticals for the treatment of gastrointestinal pain associated with Crohn's disease and irritable bowel syndrome. It acts as a potent and selective cannabinoid CB2 receptor agonist and is claimed to be orally active and peripherally selective. Initial Phase IIa exploratory clinical trials have been successful in patients with quiescent Crohn's disease. Arena initiated the Phase IIb Captivate trial in late July 2019 in patients with irritable bowel syndrome related pain, in constipation and diarrhea predominant sub-types. The Phase IIb trial is expected to enroll 240 participants between the ages of 18 and 70.Three doses of 10 mg, 25 mg, and 50 mg are being tested against Placebo in a 3:4 prescription ratio with a Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) masking layout.
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| Classification | Small molecule |
| Drug class | cannabinol derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)[C@@H](CO)NC(=O)c1nn(-c2c[n+]([O-])ccn2)c2c1C[C@@H]1C[C@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 1268881-20-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4175981 |
| ChEBI ID | — |
| PubChem CID | 60164925 |
| DrugBank | DB14998 |
| UNII ID | 581F7DFA9B (ChemIDplus, GSRS) |
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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