Nortriptyline
Nortriptyline (nortriptyline) is a small molecule pharmaceutical. Nortriptyline was first approved as Aventyl hydrochloride on 1982-01-01. It is used to treat anxiety disorders, attention deficit disorder with hyperactivity, depressive disorder, enuresis, and pain amongst others in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target G protein-activated inward rectifier potassium channel 2, ATP-sensitive inward rectifier potassium channel 10, and G protein-activated inward rectifier potassium channel 4.
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Commercial
Trade Name
FDA
EMA
Nortriptyline (discontinued: Aventyl, Nortriptyline, Pamelor)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nortriptyline hydrochloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nortriptyline hci | ANDA | 2022-10-05 |
| nortriptyline hci nortriptyline hcl | ANDA | 2019-03-11 |
| nortriptyline hcl | ANDA | 2026-09-16 |
| nortriptyline hydrochloride | ANDA | 2026-09-28 |
| pamelor | New Drug Application | 2024-12-04 |
Agency Specific
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Clinical
Clinical Trials
68 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 1 | 2 | 12 | 9 | 24 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 2 | — | 9 | 3 | 14 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 2 | — | 8 | 2 | 12 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | 5 | 1 | 7 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | 4 | 1 | 5 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 2 | 1 | 2 | 5 |
| Tinnitus | D014012 | — | H93.1 | — | — | — | 3 | — | 3 |
| Headache | D006261 | — | R51 | — | — | — | 2 | 1 | 3 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | 1 | 2 | 1 | — | 3 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | 1 | — | 2 |
Show 13 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | 1 | — | — | 2 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 1 | — | 1 | 2 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | 1 | — | — | 1 |
| Heartburn | D006356 | — | R12 | — | — | 1 | — | — | 1 |
| Non-erosive reflux disease | D000096663 | — | — | — | — | 1 | — | — | 1 |
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | — | 1 | — | — | 1 |
Show 1 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sciatica | D012585 | — | M54.3 | — | 1 | — | — | 2 | 3 |
| Radiculopathy | D011843 | — | M54.1 | — | 1 | — | — | 2 | 3 |
| Chronic pain | D059350 | — | — | — | 1 | — | — | 1 | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 2 | — | — | — | 2 |
| Temporomandibular joint disorders | D013705 | — | M26.6 | — | 2 | — | — | — | 2 |
| Back pain | D001416 | — | M54 | — | 1 | — | — | 1 | 2 |
| Tension-type headache | D018781 | — | G44.2 | — | 1 | — | — | 1 | 2 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 2 | — | — | — | 2 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | 1 | — | — | — | 1 |
| Vulvodynia | D056650 | — | N94.81 | — | 1 | — | — | — | 1 |
Show 9 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Small cell carcinoma | D018288 | — | — | 1 | — | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | — | 1 |
| Dermatitis | D003872 | — | L30.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 4 | 4 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | — | — | — | — | 1 | 1 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 1 | 1 |
| Hernia | D006547 | — | K40-K46 | — | — | — | — | 1 | 1 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 1 | 1 |
| Low back pain | D017116 | — | M54.5 | — | — | — | — | 1 | 1 |
| Intractable pain | D010148 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nortriptyline |
| INN | nortriptyline |
| Description | Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. It has a role as a drug metabolite, an antidepressant, an adrenergic uptake inhibitor, an analgesic, an antineoplastic agent and an apoptosis inducer. It is an organic tricyclic compound and a secondary amine. It is functionally related to an amitriptyline. It derives from a hydride of a dibenzo[a,d][7]annulene. |
| Classification | Small molecule |
| Drug class | antidepressants (dibenzol[a,d]cycloheptane derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNCCC=C1c2ccccc2CCc2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 72-69-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL445 |
| ChEBI ID | 7640 |
| PubChem CID | 4543 |
| DrugBank | DB00540 |
| UNII ID | BL03SY4LXB (ChemIDplus, GSRS) |
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Nortriptyline
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Safety
Black-box Warning
Black-box warning for: Nortriptyline hci, Nortriptyline hcl, Nortriptyline hydrochloride, Pamelor
Adverse Events
Top Adverse Reactions
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8,677 adverse events reported
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