Nitroprusside
Nipride, Nitroprusside (nitroprusside) is a small molecule pharmaceutical. Nitroprusside was first approved as Nitropress on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Nipride, Nitroprusside (discontinued: Nipride, Nitropress, Nitroprusside)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium nitroprusside
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NIPRIDE RTU IN SODIUM CHLORIDE 0.9% | Exela Pharma Sciences | N-209387 RX | 2017-03-08 | 2 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| nipride rtu | New Drug Application | 2018-07-20 |
| sodium nitroprusside | ANDA | 2026-08-10 |
| sodium nitroprusside in 0.9% sodium chloride | ANDA | 2023-11-15 |
Indications
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EMA
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Agency Specific
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Clinical
Clinical Trials
110 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 2 | 3 | 1 | 4 | 11 |
| Heart failure | D006333 | EFO_0003144 | I50 | 2 | 1 | 1 | 1 | 5 | 9 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 2 | 1 | 1 | 2 | 5 |
| Infarction | D007238 | EFO_0009463 | — | — | 2 | 1 | 1 | 2 | 5 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | 3 | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 1 | 2 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | 2 | 3 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | 1 | — | 2 |
| Thyroid diseases | D013959 | — | E00-E07 | — | — | — | 1 | — | 1 |
| Prehypertension | D058246 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart arrest | D006323 | EFO_0009492 | I46 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | 1 | — | — | 6 | 10 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 3 | 2 | — | — | 5 | 10 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 3 | — | — | — | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 2 | — | — | 1 | 3 |
| Hypotension | D007022 | EFO_0005251 | I95 | 1 | 1 | — | — | 1 | 3 |
| St elevation myocardial infarction | D000072657 | — | — | — | 1 | — | — | 2 | 3 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | 1 | 2 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vasodilation | D014664 | — | — | 5 | — | — | — | 5 | 10 |
| Vasoconstriction | D014661 | — | — | 4 | — | — | — | 2 | 6 |
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | — | 3 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | 2 | — | — | — | — | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | — | — | — | — | 2 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | — | — | — | 1 | 2 |
| Orthostatic intolerance | D054971 | — | — | 2 | — | — | — | — | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | 2 | — | — | — | — | 2 |
| Aneurysm | D000783 | — | I72.9 | 1 | — | — | — | 1 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 4 | 4 |
| Thrombosis | D013927 | — | — | — | — | — | — | 3 | 3 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 3 | 3 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 3 | 3 |
| Emergencies | D004630 | — | — | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Cerebral hemorrhage | D002543 | — | — | — | — | — | — | 2 | 2 |
| Microcirculation | D008833 | — | — | — | — | — | — | 2 | 2 |
| Percutaneous coronary intervention | D062645 | — | — | — | — | — | — | 2 | 2 |
| Hypercholesterolemia | D006937 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nitroprusside |
| INN | _ |
| Description | Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. This may be done if the blood pressure is very high and resulting in symptoms, in certain types of heart failure, and during surgery to decrease bleeding. It is used by continuous injection into a vein. Onset is typically immediate and effects last for up to ten minutes.
|
| Classification | Small molecule |
| Drug class | atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 13755-38-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2097081 |
| ChEBI ID | 7596 |
| PubChem CID | 11953895 |
| DrugBank | DB00325 |
| UNII ID | EAO03PE1TC (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Nipride rtu, Sodium nitroprusside, Sodium nitroprusside in 0.9% sodium chloride
Adverse Events
Top Adverse Reactions
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274 adverse events reported
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