Nitroglycerin
Nitro-dur, Nitroglycerin, Nitrolingual Pumpspray, Nitromist, Nitrostat, Rectiv (nitroglycerin) is a small molecule pharmaceutical. Nitroglycerin was first approved as Nitroglycerin on 1982-01-01. It is used to treat angina pectoris, diffuse esophageal spasm, eclampsia, fissure in ano, and heart failure amongst others in the USA.
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Commercial
Trade Name
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EMA
Nitro-dur, Nitroglycerin, Nitrolingual pumpspray, Nitromist, Nitrostat (discontinued: Gonitro, Minitran, Nitro, Nitro-bid, Nitroglycerin, Nitrol, Nitrolingual pumpspray, Nitrostat, Rectiv, Transderm-nitro, Tridil)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nitroglycerin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RECTIV | AbbVie | N-021359 RX | 2011-06-21 | 1 products, RLD, RS |
| NITROGLYCERIN IN DEXTROSE 5% | Baxter | N-019970 RX | 1989-12-29 | 3 products, RLD, RS |
| NITROMIST | Evus Health Solutions | N-021780 RX | 2006-11-02 | 1 products, RLD, RS |
| NITROLINGUAL PUMPSPRAY | Pohl-Boskamp | N-018705 RX | 1997-01-10 | 1 products, RLD, RS |
| NITRO-DUR | USpharma | N-020145 RX | 1995-04-04 | 6 products, RLD, RS |
| NITROSTAT | Viatris | N-021134 RX | 2000-05-01 | 3 products, RLD, RS |
Show 10 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| basic dental emergency kit | unapproved drug other | 2025-10-16 |
| deluxe dental emergency kit | unapproved drug other | 2025-10-16 |
| minitran | Export only | 2025-12-01 |
| nitro-bid | ANDA | 2026-01-28 |
| nitro-dur | New Drug Application | 2023-05-30 |
| nitro-time | unapproved drug other | 2025-11-19 |
| nitroglycerin | ANDA | 2026-04-02 |
| nitroglycerin in dextrose | New Drug Application | 2022-12-09 |
| nitroglycerin in dextrose | New Drug Application | 2025-12-18 |
| nitroglycerin lingual | NDA authorized generic | 2025-12-17 |
Show 8 more
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 339 | 725 | 165 | 14 | 54 | 1129 |
| Leukemia | D007938 | — | C95 | 252 | 472 | 122 | 18 | 43 | 795 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 110 | 355 | 177 | 13 | 44 | 633 |
| Multiple myeloma | D009101 | — | C90.0 | 200 | 362 | 65 | 8 | 26 | 571 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 180 | 308 | 65 | 3 | 21 | 486 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 143 | 248 | 66 | 17 | 20 | 429 |
| Plasma cell neoplasms | D054219 | — | — | 143 | 264 | 52 | 6 | 18 | 413 |
| Lymphoid leukemia | D007945 | — | C91 | 116 | 202 | 62 | 17 | 15 | 366 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 121 | 202 | 47 | 3 | 11 | 325 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 107 | 181 | 59 | 4 | 12 | 322 |
Show 197 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 220 | 178 | 26 | — | 25 | 374 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 101 | 158 | 31 | — | 12 | 264 |
| Myeloid leukemia | D007951 | — | C92 | 57 | 119 | 26 | — | 10 | 189 |
| Melanoma | D008545 | — | — | 88 | 84 | 6 | — | 6 | 152 |
| Hematologic neoplasms | D019337 | — | — | 58 | 84 | 6 | — | 8 | 133 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 70 | 74 | 10 | — | 2 | 125 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 34 | 83 | 4 | — | 11 | 121 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 52 | 48 | 22 | — | 7 | 119 |
| Triple negative breast neoplasms | D064726 | — | — | 35 | 76 | 14 | — | 5 | 112 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 24 | 86 | 8 | — | 6 | 111 |
Show 278 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 26 | 20 | — | — | 2 | 38 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 14 | 21 | — | — | 8 | 38 |
| Mycosis fungoides | D009182 | — | C84.0 | 12 | 19 | — | — | 9 | 37 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 22 | 15 | — | — | 1 | 28 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 9 | 22 | — | — | 3 | 28 |
| Mycoses | D009181 | — | B35-B49 | 8 | 17 | — | — | 5 | 27 |
| Adult t-cell leukemia-lymphoma | D015459 | — | C91.5 | 9 | 14 | — | — | 2 | 22 |
| Healthy volunteers/patients | — | — | — | 8 | 3 | — | — | 13 | 22 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 5 | 17 | — | — | 1 | 21 |
| Mesothelioma | D008654 | — | C45 | 17 | 12 | — | — | 2 | 21 |
Show 292 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | — | — | 8 | 9 |
| Pinealoma | D010871 | — | — | 6 | — | — | — | — | 6 |
| Nervous system diseases | D009422 | — | G00-G99 | 3 | — | — | — | 1 | 4 |
| Muscle weakness | D018908 | — | — | 2 | — | — | — | 1 | 3 |
| Adrenocortical carcinoma | D018268 | — | — | 3 | — | — | — | — | 3 |
| Hepatectomy | D006498 | — | — | 1 | — | — | — | 2 | 3 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | 1 | 2 |
| Papillary thyroid cancer | D000077273 | — | — | 2 | — | — | — | — | 2 |
| Colonic polyps | D003111 | — | K63.5 | 2 | — | — | — | — | 2 |
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 2 | — | — | — | — | 2 |
Show 74 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 6 | 6 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 5 | 5 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 4 | 4 |
| Anesthesia | D000758 | — | — | — | — | — | — | 4 | 4 |
| Headache | D006261 | — | R51 | — | — | — | — | 4 | 4 |
| Microvascular angina | D017566 | — | — | — | — | — | — | 3 | 3 |
| Coronary circulation | D003326 | — | — | — | — | — | — | 3 | 3 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 3 | 3 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | — | — | — | — | 3 | 3 |
| Blood circulation | D001775 | — | — | — | — | — | — | 3 | 3 |
Show 165 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nitroglycerin |
| INN | — |
| Description | Nitroglycerin is a nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain. It has a role as a vasodilator agent, a nitric oxide donor, an explosive, a prodrug, a tocolytic agent, a muscle relaxant and a xenobiotic. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=[N+]([O-])OCC(CO[N+](=O)[O-])O[N+](=O)[O-] |
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Nitroglycerin
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Safety
Black-box Warning
Black-box warning for: Nitro-dur, Nitroglycerin transdermal infusion system
Adverse Events
Top Adverse Reactions
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10,862 adverse events reported
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