Nitroglycerin
Nitro-dur, Nitroglycerin, Nitrolingual Pumpspray, Nitromist, Nitrostat, Rectiv (nitroglycerin) is a small molecule pharmaceutical. Nitroglycerin was first approved as Nitroglycerin on 1982-01-01. It is used to treat angina pectoris, diffuse esophageal spasm, eclampsia, fissure in ano, and heart failure amongst others in the USA.
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Commercial
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Nitro-dur, Nitrolingual pumpspray, Nitromist, Nitrostat, Rectiv (generic drugs available since 1988-05-24, discontinued: Gonitro, Minitran, Nitro, Nitro-bid, Nitrol, Nitrolingual, Nitronal, Transderm-nitro, Tridil)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nitroglycerin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| RECTIV | AbbVie | N-021359 RX | 2011-06-21 | 1 products, RLD, RS |
| NITROGLYCERIN IN DEXTROSE 5% | Baxter | N-019970 RX | 1989-12-29 | 3 products, RLD, RS |
| NITROMIST | Evus Health Solutions | N-021780 RX | 2006-11-02 | 1 products, RLD, RS |
| NITROLINGUAL PUMPSPRAY | Pohl-Boskamp | N-018705 RX | 1997-01-10 | 1 products, RLD, RS |
| NITRO-DUR | USpharma | N-020145 RX | 1995-04-04 | 6 products, RLD, RS |
| NITROSTAT | Viatris | N-021134 RX | 2000-05-01 | 3 products, RLD, RS |
Show 10 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| basic dental emergency kit | unapproved drug other | 2024-10-03 |
| deluxe dental emergency kit | unapproved drug other | 2024-10-03 |
| gonitro | New Drug Application | 2018-06-20 |
| minitran | Export only | 2023-01-25 |
| nitro-bid | ANDA | 2024-09-04 |
| nitro-dur | New Drug Application | 2023-05-30 |
| nitro-time | unapproved drug other | 2018-10-09 |
| nitroglycerin | ANDA | 2024-08-13 |
| nitroglycerin in dextrose | New Drug Application | 2022-12-09 |
| nitroglycerin in dextrose | New Drug Application | 2016-08-22 |
Show 9 more
Indications
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 28 | 44 | 10 | 2 | 6 | 79 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 15 | 24 | 2 | 1 | 4 | 37 |
| Coronary artery disease | D003324 | — | I25.1 | 2 | 4 | 1 | 9 | 20 | 36 |
| B-cell lymphoma | D016393 | — | — | 13 | 11 | 2 | 1 | 4 | 26 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 2 | 3 | 2 | 6 | 12 | 25 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 11 | 10 | 2 | 1 | 4 | 25 |
| Coronary disease | D003327 | — | — | 1 | 3 | 1 | 6 | 9 | 20 |
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | — | 3 | 1 | 10 | 18 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 3 | 4 | 8 | 15 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 3 | 4 | 8 | 15 |
Show 57 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 18 | 31 | 4 | — | 2 | 46 |
| Leukemia | D007938 | — | C95 | 15 | 23 | 5 | — | 4 | 43 |
| Plasma cell neoplasms | D054219 | — | — | 17 | 27 | 4 | — | 1 | 40 |
| Neoplasms | D009369 | — | C80 | 14 | 22 | 3 | — | 5 | 40 |
| Recurrence | D012008 | — | — | 20 | 23 | 1 | — | 5 | 39 |
| Sarcoma | D012509 | — | — | 7 | 13 | 10 | — | 6 | 33 |
| Hodgkin disease | D006689 | — | C81 | 11 | 22 | 3 | — | 3 | 33 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 12 | 12 | 4 | — | 3 | 29 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 12 | 11 | 2 | — | 2 | 25 |
| Myeloid leukemia | D007951 | — | C92 | 11 | 11 | 1 | — | 2 | 23 |
Show 95 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mycoses | D009181 | — | B35-B49 | 1 | 8 | — | — | 6 | 15 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | 8 | — | — | 6 | 15 |
| Mantle-cell lymphoma | D020522 | — | — | 7 | 8 | — | — | 3 | 14 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 2 | 11 | — | — | 1 | 14 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 6 | 6 | — | — | 1 | 13 |
| Healthy volunteers/patients | — | — | — | 4 | 1 | — | — | 9 | 13 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 4 | 9 | — | — | 1 | 12 |
| Follicular lymphoma | D008224 | — | C82 | 4 | 7 | — | — | 4 | 12 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 5 | 6 | — | — | 3 | 12 |
| T-cell lymphoma cutaneous | D016410 | — | — | — | 6 | — | — | 5 | 11 |
Show 164 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | — | — | 9 | 10 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 3 | 4 |
| Rhabdoid tumor | D018335 | — | — | 3 | — | — | — | — | 3 |
| Ependymoma | D004806 | — | — | 2 | — | — | — | 1 | 3 |
| Hepatectomy | D006498 | — | — | 1 | — | — | — | 2 | 3 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | — | — | — | 1 | 2 |
| Colonic polyps | D003111 | — | K63.5 | 2 | — | — | — | — | 2 |
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 2 | — | — | — | — | 2 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | — | — | — | — | 2 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | 1 | 2 |
Show 41 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 6 | 6 |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 5 | 5 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 4 | 4 |
| Microvascular angina | D017566 | — | — | — | — | — | — | 3 | 3 |
| Coronary circulation | D003326 | — | — | — | — | — | — | 3 | 3 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | — | — | — | 3 | 3 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 3 | 3 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | — | — | — | — | 3 | 3 |
| Dysmenorrhea | D004412 | HP_0100607 | N94.6 | — | — | — | — | 2 | 2 |
| Intraocular lymphoma | D064090 | — | — | — | — | — | — | 2 | 2 |
Show 124 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nitroglycerin |
| INN | — |
| Description | Nitroglycerin is a nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain. It has a role as a vasodilator agent, a nitric oxide donor, an explosive, a prodrug, a tocolytic agent, a muscle relaxant and a xenobiotic. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=[N+]([O-])OCC(CO[N+](=O)[O-])O[N+](=O)[O-] |
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Nitroglycerin
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Safety
Black-box Warning
Black-box warning for: Nitro-dur, Nitroglycerin transdermal infusion system
Adverse Events
Top Adverse Reactions
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9,159 adverse events reported
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