Nipocalimab
Nipocalimab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target IgG receptor FcRn large subunit p51.
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Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemolysis | D006461 | — | — | — | 2 | 2 | — | 2 | 5 |
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | — | 3 | 2 | — | — | 4 |
| Muscle weakness | D018908 | — | — | — | 3 | 2 | — | — | 4 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 1 | 1 | — | 1 | 2 |
| Hemolytic anemia autoimmune | D000744 | EFO_1001264 | D59.10 | — | 1 | 1 | — | 1 | 2 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | 1 | 1 | — | 1 | 2 |
| Sjogren's syndrome | D012859 | EFO_0000699 | M35.0 | — | 1 | 1 | — | — | 2 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | 2 | — | — | 2 |
| Neonatal alloimmune thrombocytopenia | D054098 | — | — | — | — | 2 | — | — | 2 |
| Polyneuropathies | D011115 | EFO_0009562 | A69.22 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 2 | — | — | — | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 2 | — | — | — | 2 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | 1 | — | — | — | 1 |
| Nephritis | D009393 | — | N05 | — | 1 | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Myositis | D009220 | EFO_0000783 | G72.49 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
| Fetal erythroblastosis | D004899 | EFO_1000937 | P55 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nipocalimab |
| INN | nipocalimab |
| Description | Nipocalimab is an antibody pharmaceutical. It is currently being investigated in clinical studies. |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4594310 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 87M90CV8NC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
FCGRT
FCGRT
Organism
Homo sapiens
Gene name
FCGRT
Gene synonyms
FCRN
NCBI Gene ID
Protein name
IgG receptor FcRn large subunit p51
Protein synonyms
Fc fragment of IgG receptor and transporter, Fc fragment of IgG, receptor, transporter, alpha, FcRn alpha chain, heavy chain of the major histocompatibility complex class I-like Fc receptor, IgG Fc fragment receptor transporter alpha chain, immunoglobulin receptor, intestinal, heavy chain, major histocompatibility complex class I-like Fc receptor, Neonatal Fc receptor, neonatal Fc-receptor for Ig, neonatal fragment crystallizable Fc receptor FcRn, transmembrane alpha chain of the neonatal receptor
Uniprot ID
Mouse ortholog
Fcgrt (14132)
IgG receptor FcRn large subunit p51 (Q9R2A5)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 349 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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