Nimotuzumab
Nimotuzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target epidermal growth factor receptor.
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Commercial
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Clinical
Clinical Trials
157 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 2 | 28 | 7 | 1 | 3 | 39 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 1 | 15 | 6 | 1 | 1 | 24 |
| Squamous cell carcinoma | D002294 | — | — | 2 | 18 | 2 | 1 | 3 | 23 |
| Nasopharyngeal neoplasms | D009303 | — | — | 1 | 12 | 6 | 1 | — | 20 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 11 | 3 | 1 | 2 | 15 |
| Head and neck neoplasms | D006258 | — | — | — | 2 | 2 | 1 | — | 5 |
| Premature obstetric labor | D007752 | — | O60 | — | — | — | 1 | — | 1 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | 1 | — | 1 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esophageal neoplasms | D004938 | — | C15 | 1 | 13 | 3 | — | — | 16 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 1 | 15 | 3 | — | — | 16 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 7 | 2 | — | 3 | 12 |
| Uterine cervical neoplasms | D002583 | — | — | 1 | 9 | 3 | — | — | 12 |
| Neoplasms | D009369 | — | C80 | 4 | 4 | 2 | — | 1 | 11 |
| Chemoradiotherapy | D059248 | — | — | — | 4 | 2 | — | — | 6 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 4 | 1 | — | — | 5 |
| Adenocarcinoma | D000230 | — | — | 1 | 5 | 1 | — | — | 5 |
| Colorectal neoplasms | D015179 | — | — | 2 | 4 | 1 | — | — | 5 |
| Immunotherapy | D007167 | — | — | — | 3 | 2 | — | — | 5 |
Show 15 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 7 | — | — | 2 | 11 |
| Lung neoplasms | D008175 | — | C34.90 | 4 | 7 | — | — | 1 | 9 |
| Squamous cell neoplasms | D018307 | — | — | 1 | 4 | — | — | — | 4 |
| Glioma | D005910 | EFO_0000520 | — | — | 2 | — | — | 2 | 4 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 3 | — | — | — | 3 |
| Oropharyngeal neoplasms | D009959 | — | — | — | 2 | — | — | — | 2 |
| Adenosquamous carcinoma | D018196 | — | — | — | 2 | — | — | — | 2 |
| Drug therapy | D004358 | — | — | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Hypopharyngeal neoplasms | D007012 | — | C13 | — | 1 | — | — | — | 1 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adoptive transfer | D019264 | — | — | 1 | — | — | — | — | 1 |
| Antibody-dependent cell cytotoxicity | D000920 | — | — | 1 | — | — | — | — | 1 |
| Cellular immunity | D007111 | — | — | 1 | — | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dengue | D003715 | — | A90 | — | — | — | — | 1 | 1 |
| Healthy volunteers/patients | — | — | — | — | — | — | — | 1 | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 1 | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 1 | 1 |
| Dyssomnias | D020920 | — | — | — | — | — | — | 1 | 1 |
| Parasomnias | D020447 | — | G47.5 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nimotuzumab |
| INN | nimotuzumab |
| Description | Nimotuzumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >3GKW:H|Heavy chain of the antibody Nimotuzumab
QVQLQQSGAEVKKPGSSVKVSCKASGYTFTNYYIYWVRQAPGQGLEWIGGINPTSGGSNFNEKFKTRVTITADESSTTAY
MELSSLRSEDTAFYFCTRQGLWFDSDGRGFDFWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV
TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVP
>3GKW:L|Light chain of the antibody Nimotuzumab
DIQMTQSPSSLSASVGDRVTITCRSSQNIVHSNGNTYLDWYQQTPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTFTI
SSLQPEDIATYYCFQYSHVPWTFGQGTKLQITREVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 3GKW |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108359 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 6NS400BXKH (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
EGFR
EGFR
Organism
Homo sapiens
Gene name
EGFR
Gene synonyms
ERBB, ERBB1, HER1
NCBI Gene ID
Protein name
epidermal growth factor receptor
Protein synonyms
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR vIII, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Uniprot ID
Mouse ortholog
Egfr (13649)
epidermal growth factor receptor (Q01279)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,317 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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85 adverse events reported
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