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Drug ReportsNimesulide
Nimesulide
Nimesulide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target sodium-dependent neutral amino acid transporter B(0)AT1.
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Drug Products
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Abbreviated New Drug Application (ANDA)
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Status
Last Update
3ce lip color 805 r 19OTC monograph not final2016-10-04
Indications
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AX: Other antiinflammatory and antirheumatic agents, non-steroids in atc
— M01AX17: Nimesulide
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA26: Nimesulide
HCPCS
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
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Total
PainD010146EFO_0003843R521————1
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNimesulide
INNnimesulide
Description
Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a C-nitro compound, a sulfonamide and an aromatic ether. It is functionally related to a nitrobenzene.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1
Identifiers
PDB—
CAS-ID51803-78-2
RxCUI—
ChEMBL IDCHEMBL56367
ChEBI ID44445
PubChem CID4495
DrugBankDB04743
UNII IDV4TKW1454M (ChemIDplus, GSRS)
Target
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Variants
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Trends
PubMed Central
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Safety
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1,511 adverse events reported
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