Nimesulide
Nimesulide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target sodium-dependent neutral amino acid transporter B(0)AT1.
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Brand Name | Status | Last Update |
|---|---|---|
| 3ce lip color 805 r 19 | OTC monograph not final | 2016-10-04 |
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AX: Other antiinflammatory and antirheumatic agents, non-steroids in atc
— M01AX17: Nimesulide
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA26: Nimesulide
HCPCS
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 1 | 1 | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | 1 | 1 | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | 1 | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
| Communicable diseases | D003141 | — | — | — | — | — | 1 | — | 1 |
| Pharyngitis | D010612 | — | R07.0 | — | — | — | 1 | — | 1 |
| Laryngitis | D007827 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peri-implantitis | D057873 | EFO_1001390 | — | — | 1 | 1 | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | 1 | — | — | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Temporomandibular joint disorders | D013705 | — | M26.6 | — | 1 | — | — | 2 | 3 |
| Temporomandibular joint dysfunction syndrome | D013706 | — | — | — | 1 | — | — | 2 | 3 |
| Joint diseases | D007592 | HP_0003040 | M12.9 | — | 1 | — | — | 1 | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 2 |
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Bursitis | D002062 | EFO_1000941 | M71.9 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | — | — | 2 | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 1 | 1 |
| Leg ulcer | D007871 | — | — | — | — | — | — | 1 | 1 |
| Venous insufficiency | D014689 | — | — | — | — | — | — | 1 | 1 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nimesulide |
| INN | nimesulide |
| Description | Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a C-nitro compound, a sulfonamide and an aromatic ether. It is functionally related to a nitrobenzene. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 51803-78-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL56367 |
| ChEBI ID | 44445 |
| PubChem CID | 4495 |
| DrugBank | DB04743 |
| UNII ID | V4TKW1454M (ChemIDplus, GSRS) |
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Safety
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1,257 adverse events reported
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