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Drug ReportsNimesulide
Nimesulide
Nimesulide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target sodium-dependent neutral amino acid transporter B(0)AT1.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Status
Last Update
3ce lip color 805 r 19OTC monograph not final2016-10-04
Indications
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ATC Codes
M: Musculo-skeletal system drugs
M01: Antiinflammatory and antirheumatic products
M01A: Antiinflammatory and antirheumatic products, non-steroids
M01AX: Other antiinflammatory and antirheumatic agents, non-steroids in atc
M01AX17: Nimesulide
M02: Topical products for joint and muscular pain
M02A: Topical products for joint and muscular pain
M02AA: Antiinflammatory preparations, non-steroids for topical use
M02AA26: Nimesulide
HCPCS
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17112
OsteoarthritisD010003EFO_0002506M15-M19112
Respiratory tract infectionsD012141J06.911
InfectionsD007239EFO_000054411
Communicable diseasesD00314111
PharyngitisD010612R07.011
LaryngitisD00782711
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peri-implantitisD057873EFO_1001390111
InflammationD007249MP_000184511
DyspepsiaD004415EFO_0008533K3011
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Temporomandibular joint disordersD013705M26.6123
Temporomandibular joint dysfunction syndromeD013706123
Joint diseasesD007592HP_0003040M12.9112
Colorectal neoplasmsD015179112
ArthralgiaD018771HP_0002829M25.511
SyndromeD01357711
Breast neoplasmsD001943EFO_0003869C5011
BursitisD002062EFO_1000941M71.911
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8011
PainD010146EFO_0003843R5211
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Low back painD017116HP_0003419M54.522
UlcerD014456MPATH_57911
Leg ulcerD00787111
Venous insufficiencyD01468911
Back painD001416HP_0003418M5411
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNimesulide
INNnimesulide
Description
Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a C-nitro compound, a sulfonamide and an aromatic ether. It is functionally related to a nitrobenzene.
Classification
Small molecule
Drug class
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Structure (InChI/SMILES or Protein Sequence)
CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1
Identifiers
PDB
CAS-ID51803-78-2
RxCUI
ChEMBL IDCHEMBL56367
ChEBI ID44445
PubChem CID4495
DrugBankDB04743
UNII IDV4TKW1454M (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,257 adverse events reported
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