Nifedipine
Nifedipine, Procardia (nifedipine) is a small molecule pharmaceutical. Nifedipine was first approved as Procardia on 1982-01-01. It is used to treat hypertension, stable angina, and variant angina pectoris in the USA. It is known to target voltage-dependent L-type calcium channel subunit alpha-1F, glycine receptor subunit alpha-3, voltage-gated potassium channel KCNC1, voltage-dependent L-type calcium channel subunit alpha-1S, potassium voltage-gated channel subfamily A member 5, potassium voltage-gated channel subfamily A member 7, glycine receptor subunit beta, potassium voltage-gated channel subfamily A member 2, nuclear receptor subfamily 1 group I member 2, transient receptor potential cation channel subfamily M member 3, voltage-dependent L-type calcium channel subunit alpha-1C, voltage-dependent L-type calcium channel subunit alpha-1D, glycine receptor subunit alpha-1, and potassium voltage-gated channel subfamily A member 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Nifedipine, Procardia (discontinued: Adalat, Afeditab, Nifedipine, Procardia)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| adalat cc | New Drug Application | 2014-05-14 |
| afeditab | ANDA | 2016-08-06 |
| nifediac cc | ANDA | 2010-06-07 |
| nifedical | ANDA | 2013-09-26 |
| nifedicalxl | ANDA | 2013-10-02 |
| nifedipine | ANDA | 2025-03-25 |
| nifedipine nifedipine | ANDA | 2011-01-11 |
| nifedipine er | ANDA | 2011-01-11 |
| procardia | New Drug Application | 2023-11-27 |
| procardia xl | New Drug Application | 2011-12-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypertension | EFO_0000537 | D006973 | I10 |
| stable angina | — | D060050 | I20.89 |
| variant angina pectoris | — | D000788 | I20.1 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB03: Atenolol and nifedipine
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA05: Nifedipine
— C08CA55: Nifedipine, combinations
— C08G: Calcium channel blockers and diuretics
— C08GA: Calcium channel blockers and diuretics
— C08GA01: Nifedipine and diuretics
HCPCS
No data
Clinical
Clinical Trials
179 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | 7 | 12 | 33 | 19 | 72 |
| Premature obstetric labor | D007752 | — | O60 | 2 | 6 | 9 | 5 | 12 | 31 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | 4 | 6 | 5 | 10 | 25 |
| Pregnancy-induced hypertension | D046110 | — | O13 | 2 | 2 | 2 | 11 | 4 | 20 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 3 | 2 | 2 | 9 | 5 | 19 |
| Essential hypertension | D000075222 | — | I10 | 2 | 1 | 5 | 6 | 3 | 17 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | 2 | 1 | 1 | 4 | 10 |
| Fissure in ano | D005401 | — | K60.2 | 2 | 5 | 3 | 1 | — | 6 |
| Hyperaldosteronism | D006929 | — | E26 | — | — | — | 2 | 3 | 5 |
| Altitude sickness | D000532 | EFO_1000782 | T70.29 | — | — | — | 2 | 2 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Proteinuria | D011507 | — | R80 | 2 | 3 | 1 | — | — | 5 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 1 | — | 3 | 4 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | 1 | — | 2 | 3 |
| Toxemia | D014115 | — | — | 1 | 1 | 1 | — | 1 | 3 |
| Morbid obesity | D009767 | EFO_0001074 | — | 1 | 1 | 1 | — | — | 2 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | 2 | — | — | 2 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | 2 | — | — | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 2 | — | — | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | 1 | — | — | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | 2 | 2 | — | — | 4 | 8 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | — | 2 | 3 |
| Ischemic stroke | D000083242 | — | — | — | 1 | — | — | 1 | 2 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | 1 | 1 | — | — | 1 | 2 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | 1 | — | — | 1 | 2 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 2 | — | — | — | 2 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | — | — | — | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | 1 | — | — | — | 1 |
| Partial epilepsies | D004828 | EFO_0004263 | — | — | 1 | — | — | — | 1 |
| Embryo implantation | D010064 | — | — | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | 1 | — | — | — | 2 | 3 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | 1 | — | — | — | 2 | 3 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 2 | — | — | — | — | 2 |
| Sclerosis | D012598 | — | — | 1 | — | — | — | 1 | 2 |
| Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | — | — | — | — | 1 |
| Pregnancy complications | D011248 | — | — | 1 | — | — | — | — | 1 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Edema | D004487 | — | R60.9 | — | — | — | — | 3 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 2 | 2 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 2 | 2 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 2 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 2 | 2 |
| Urinary tract infections | D014552 | EFO_0003103 | N39.0 | — | — | — | — | 2 | 2 |
| Hypokalemia | D007008 | — | E87.6 | — | — | — | — | 2 | 2 |
| Sleep initiation and maintenance disorders | D007319 | — | F51.01 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nifedipine |
| INN | nifedipine |
| Description | Nifedipine is a dihydropyridine, a methyl ester and a C-nitro compound. It has a role as a calcium channel blocker, a vasodilator agent, a tocolytic agent and a human metabolite. |
| Classification | Small molecule |
| Drug class | phenylpyridine vasodilators; tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] |
Identifiers
| PDB | — |
| CAS-ID | 21829-25-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL193 |
| ChEBI ID | 7565 |
| PubChem CID | 4485 |
| DrugBank | DB01115 |
| UNII ID | I9ZF7L6G2L (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNC1
KCNC1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
Uniprot ID
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Nifedipine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 28,795 documents
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Safety
Black-box Warning
Black-box warning for: Nifedipine nifedipine, Nifedipine er
Adverse Events
Top Adverse Reactions
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13,293 adverse events reported
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