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Drug ReportsNifedipine
Nifedipine
Nifedipine, Procardia (nifedipine) is a small molecule pharmaceutical. Nifedipine was first approved as Procardia on 1982-01-01. It is used to treat hypertension, stable angina, and variant angina pectoris in the USA. It is known to target voltage-dependent L-type calcium channel subunit alpha-1F, glycine receptor subunit alpha-3, voltage-gated potassium channel KCNC1, voltage-dependent L-type calcium channel subunit alpha-1S, potassium voltage-gated channel subfamily A member 5, potassium voltage-gated channel subfamily A member 7, glycine receptor subunit beta, potassium voltage-gated channel subfamily A member 2, nuclear receptor subfamily 1 group I member 2, transient receptor potential cation channel subfamily M member 3, voltage-dependent L-type calcium channel subunit alpha-1C, voltage-dependent L-type calcium channel subunit alpha-1D, glycine receptor subunit alpha-1, and potassium voltage-gated channel subfamily A member 1.
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Events Timeline
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FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Nifedipine, Procardia (discontinued: Adalat, Afeditab, Nifedipine, Procardia)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nifedipine
Tradename
Company
Number
Date
Products
PROCARDIAPfizerN-018482 RX1982-01-01
1 products, RLD, RS
PROCARDIA XLPfizerN-019684 RX1989-09-06
3 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adalat ccNew Drug Application2014-05-14
afeditabANDA2016-08-06
nifediac ccANDA2010-06-07
nifedicalANDA2013-09-26
nifedicalxlANDA2013-10-02
nifedipineANDA2025-09-19
nifedipine nifedipineANDA2011-01-11
nifedipine erANDA2011-01-11
procardiaNew Drug Application2023-11-27
procardia xlNew Drug Application2011-12-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
stable angina—D060050I20.89
variant angina pectoris—D000788I20.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB03: Atenolol and nifedipine
— C08: Calcium channel blockers
— C08C: Selective calcium channel blockers with mainly vascular effects
— C08CA: Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects
— C08CA05: Nifedipine
— C08CA55: Nifedipine, combinations
— C08G: Calcium channel blockers and diuretics
— C08GA: Calcium channel blockers and diuretics
— C08GA01: Nifedipine and diuretics
HCPCS
No data
Clinical
Clinical Trials
186 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNifedipine
INNnifedipine
Description
Nifedipine is a dihydropyridine, a methyl ester and a C-nitro compound. It has a role as a calcium channel blocker, a vasodilator agent, a tocolytic agent and a human metabolite.
Classification
Small molecule
Drug classphenylpyridine vasodilators; tricyclic compounds
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]
Identifiers
PDB—
CAS-ID21829-25-4
RxCUI—
ChEMBL IDCHEMBL193
ChEBI ID7565
PubChem CID4485
DrugBankDB01115
UNII IDI9ZF7L6G2L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNC1
KCNC1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
3746
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
Uniprot ID
Q3KNS8
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Nifedipine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 30,072 documents
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Safety
Black-box Warning
Black-box warning for: Nifedipine nifedipine, Nifedipine er
Adverse Events
Top Adverse Reactions
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13,658 adverse events reported
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