NIDUFEXOR
Nidufexor is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target bile acid receptor.
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FDA approval date
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Study first post date
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Commercial
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Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 1 | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | 1 | — | — | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NIDUFEXOR |
| INN | nidufexor |
| Description | Nidufexor (LMB-763) is a drug which acts as a partial agonist of the farnesoid X receptor (FXR). It has reached Phase II clinical trials for the treatment of diabetic nephropathy and nonalcoholic steatohepatitis.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1nc(C(=O)N(Cc2ccccc2)Cc2ccc(C(=O)O)cc2)c2c1-c1cc(Cl)ccc1OC2 |
Identifiers
| PDB | — |
| CAS-ID | 1773489-72-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297626 |
| ChEBI ID | — |
| PubChem CID | 118063735 |
| DrugBank | — |
| UNII ID | CJ1PL0TE6J (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NR1H4
NR1H4
Organism
Homo sapiens
Gene name
NR1H4
Gene synonyms
BAR, FXR, HRR1, RIP14
NCBI Gene ID
Protein name
bile acid receptor
Protein synonyms
farnesoid X nuclear receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Uniprot ID
Mouse ortholog
Nr1h4 (20186)
bile acid receptor (Q60641)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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