PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsNicotine
Nicotine
Habitrol, Nicoderm Cq, Nicotine, Nicotrol (nicotine) is a small molecule pharmaceutical. Nicotine was first approved as Nicotrol on 1996-03-22. It is used to treat tobacco use disorder and ulcerative colitis in the USA. It is known to target transient receptor potential cation channel subfamily A member 1, P2Y purinoceptor 11, hydroxycarboxylic acid receptor 1, neuronal acetylcholine receptor subunit alpha-4, hydroxycarboxylic acid receptor 2, transient receptor potential cation channel subfamily M member 2, A-type voltage-gated potassium channel KCND3, neuronal acetylcholine receptor subunit alpha-9, hydroxycarboxylic acid receptor 3, neuronal acetylcholine receptor subunit alpha-10, and neuronal acetylcholine receptor subunit alpha-3.
Download report
Favorite
Searched
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Habitrol, Nicoderm cq, Nicorette, Nicotine, Nicotine polacrilex, Nicotrol (discontinued: Nicotine polacrilex, Nicotrol, Prostep, Thrive)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nicotine polacrilex
Tradename
Company
Number
Date
Products
NICORETTEGSKN-018612 OTC1996-02-09
1 products, RLD
NICORETTE (MINT)GSKN-018612 OTC1998-12-23
1 products, RLD
NICORETTEGSKN-018612 OTC2000-09-25
1 products, RLD
NICORETTEGSKN-020066 OTC1996-02-09
1 products, RLD, RS
NICORETTE (MINT)GSKN-020066 OTC1998-12-23
1 products, RLD
NICORETTEGSKN-020066 OTC2000-09-25
1 products, RLD
NICORETTEGSKN-022360 OTC2009-05-18
2 products, RLD, RS
NICORETTEGSKN-021330 OTC2002-10-31
2 products, RLD, RS
Nicotine
Tradename
Company
Number
Date
Products
NICODERM CQSanofiN-020165 OTC1996-08-02
3 products, RLD
HABITROLDr Reddys LaboratoriesN-020076 OTC1999-11-12
3 products, RLD, RS
NICOTROLPfizerN-020385 RX1996-03-22
1 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amazon basic care nicotine polacrilexANDA2025-05-02
aroamas cot nicotine transdermal patches kitC2002632025-06-24
atevke quit smoking nicotineC2002632025-11-14
basic care nicotineANDA2025-10-10
berkley and jensen nicotineANDA2025-11-04
berkley and jensen nicotine polacrilexANDA2025-09-20
blipANDA2025-10-13
botasun quit smoking nicotineC2002632025-06-19
care one nicotineANDA2025-03-26
careone mini nicotine polacrilexANDA2023-10-25
Show 112 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
ulcerative colitisEFO_0000729D003093K51
tobacco use disorder—D014029F17
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07B: Drugs used in addictive disorders
— N07BA: Drugs used in nicotine dependence
— N07BA01: Nicotine
HCPCS
Code
Description
S4990
Nicotine patches, legend
S4991
Nicotine patches, non-legend
Clinical
Clinical Trials
2557 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Tobacco use disorderD014029—F17871204965307595
Smoking cessationD016540EFO_0004319—44533868266452
SmokingD012907EFO_0004318—33342137208318
Cigarette smokingD000073865——2025613104161
Tobacco useD064424—Z72.08573104125
VapingD000072137——762894117
Tobacco smokingD000073869——7521284108
Tobacco use cessationD020340——4107125078
Substance-related disordersD019966EFO_0003890F1374135367
SchizophreniaD012559EFO_0000692F207122163367
Show 90 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13—13—1822
StrokeD020521EFO_0000712I63.91—1—1214
Covid-19D000086382—U07.1—34—714
Post-traumatic stress disordersD013313EFO_0001358F43.1211—1114
Lung diseasesD008171EFO_0003818J98.4111—1013
Harm reductionD040261——323—613
AnesthesiaD000758————1—1213
AsthmaD001249EFO_0000270J45—21—912
Wounds and injuriesD014947—T14.8——2—1012
Traumatic stress disordersD040921——211—710
Show 64 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———132——3549
ObesityD009765EFO_0001073E66.914——2328
Breast neoplasmsD001943EFO_0003869C5012——2427
AnxietyD001007EFO_0005230F41.113——2225
Chronic painD059350———1——1718
OverweightD050177—E66.313——1013
Psychological distressD000079225——31——69
CannabisD002188——41——27
Medication adherenceD055118EFO_0006344——1——45
Alcohol-related disordersD019973—F10—2——24
Show 63 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Anxiety disordersD001008EFO_0006788F41.13———2124
Prostatic neoplasmsD011471—C611———89
CarcinomaD002277—C80.01———89
EmergenciesD004630——1———89
Autism spectrum disorderD000067877—F84.01———56
PeriodontitisD010518EFO_0000649K05.31———45
Periodontal diseasesD010510—K05.61———45
Autistic disorderD001321EFO_0003758F84.01———34
Squamous cell carcinoma of head and neckD000077195——1———23
AgingD000375GO_0007568R41.811———23
Show 30 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acceptance and commitment therapyD064869——————1010
Sedentary behaviorD057185——————99
HypoxiaD000860—R09.02————88
ApneaD001049—R06.81————88
Heart failureD006333EFO_0003144I50————77
Heart disease risk factorsD000082742——————77
Chronic diseaseD002908——————77
Health behaviorD015438——————77
Suicidal ideationD059020EFO_0004320R45.851————66
Motor activityD009043EFO_0003940—————66
Show 445 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameNicotine
INN—
Description
(S)-nicotine is a 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. It has a role as a phytogenic insecticide, a teratogenic agent, a neurotoxin, an anxiolytic drug, a nicotinic acetylcholine receptor agonist, a biomarker, an immunomodulator, a mitogen, a peripheral nervous system drug, a psychotropic drug, a plant metabolite and a xenobiotic. It is a conjugate base of a (S)-nicotinium(1+). It is an enantiomer of a (R)-nicotine.
Classification
Small molecule
Drug classStimulant; Nootropic; Euphoriant
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1CCC[C@H]1c1cccnc1
Identifiers
PDB—
CAS-ID54-11-5
RxCUI—
ChEMBL IDCHEMBL3
ChEBI ID17688
PubChem CID89594
DrugBankDB00184
UNII ID—
Target
Agency Approved
No data
Alternate
KCND3
KCND3
Organism
Homo sapiens
Gene name
KCND3
Gene synonyms
NCBI Gene ID
3752
Protein name
potassium voltage-gated channel subfamily D member 3
Protein synonyms
potassium channel, voltage gated Shal related subfamily D, member 3, potassium ionic channel Kv4.3, potassium voltage-gated channel long, potassium voltage-gated channel, Shal-related subfamily, member 3, sha1-related potassium channel Kv4.3, voltage-gated K+ channel, Voltage-gated potassium channel subunit Kv4.3
Uniprot ID
Q9UK17
Mouse ortholog
Kcnd3 (56543)
potassium voltage-gated channel subfamily D member 3 (Q9Z0V1)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Nicotine
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 129,186 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
62,805 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use