Nicardipine
Cardene, Nicardipine (nicardipine) is a small molecule pharmaceutical. Nicardipine was first approved as Cardene on 1988-12-21. It is used to treat hypertension, stable angina, and variant angina pectoris in the USA. It is known to target potassium voltage-gated channel subfamily A member 4 and adenosine receptor A3.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Cardene, Nicardipine (discontinued: Cardene, Nicardipine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Nicardipine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CARDENE IN 4.8% DEXTROSE IN PLASTIC CONTAINER | Chiesi Farmaceutici | N-019734 RX | 2008-07-31 | 1 products, RLD, RS |
| CARDENE IN 0.86% SODIUM CHLORIDE IN PLASTIC CONTAINER | Chiesi Farmaceutici | N-019734 RX | 2008-07-31 | 1 products, RLD, RS |
| CARDENE IN 0.83% SODIUM CHLORIDE IN PLASTIC CONTAINER | Chiesi Farmaceutici | N-019734 RX | 2008-11-07 | 1 products, RLD, RS |
| NICARDIPINE HYDROCHLORIDE | Hikma Pharmaceuticals | N-022276 RX | 2008-07-24 | 1 products, RLD, RS |
| NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE | Hikma Pharmaceuticals | N-022276 RX | 2016-04-07 | 2 products, RLD, RS |
Show 5 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cardene | New Drug Application | 2016-08-06 |
| cardene iv | New Drug Application | 2024-09-27 |
| nicardipine hydrochloride | ANDA | 2024-11-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypertension | EFO_0000537 | D006973 | I10 |
| stable angina | — | D060050 | I20.89 |
| variant angina pectoris | — | D000788 | I20.1 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
NICARDIPINE HYDROCHLORIDE, NICARDIPINE HYDROCHLORIDE, SENORES PHARMS | |||
| 2024-03-20 | CGT | ||
HCPCS
No data
Clinical
Clinical Trials
58 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | 5 | 3 | 6 | 16 |
| Ischemic stroke | D000083242 | — | — | — | — | 2 | 1 | 1 | 4 |
| Covid-19 | D000086382 | — | — | — | — | — | 1 | 2 | 3 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | 1 | — | 1 | 1 | 3 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | 1 | 1 | 3 |
| Emergencies | D004630 | — | — | — | — | — | 2 | 1 | 3 |
| Hypertensive crisis | D000096003 | — | — | — | — | — | 2 | 1 | 3 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | 2 | 1 | 3 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | — | — | 1 | 1 | 2 |
| Angle class iii malocclusion | D008313 | HP_0000303 | M26.213 | — | — | — | 1 | — | 1 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 1 | 1 | — | 9 | 12 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | 2 | — | 4 | 8 |
| Cerebral hemorrhage | D002543 | — | — | 1 | — | 1 | — | 5 | 7 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | 2 | — | 1 | 3 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | 1 | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | — | 2 | — | — | 2 |
| Muscle cramp | D009120 | HP_0003394 | — | — | — | 1 | — | — | 1 |
| Spasm | D013035 | — | M62.83 | — | — | 1 | — | — | 1 |
| Vasodilation | D014664 | — | — | — | — | 1 | — | — | 1 |
| Eclampsia | D004461 | HP_0100601 | O15 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | 1 | — | — | 3 | 4 |
| Thrombectomy | D017131 | — | — | — | 1 | — | — | — | 1 |
| Aneurysm | D000783 | HP_0002617 | I72.9 | — | 1 | — | — | — | 1 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | — | 1 | — | — | — | 1 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Coronary disease | D003327 | — | — | 1 | — | — | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | — | — | — | — | 1 |
| Burns | D002056 | — | T30.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | — | — | — | 2 | 2 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | — | — | 1 | 1 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 1 | 1 |
| Mucocutaneous lymph node syndrome | D009080 | EFO_0004246 | M30.3 | — | — | — | — | 1 | 1 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | — | — | 1 | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 1 | 1 |
Show 31 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Nicardipine |
| INN | nicardipine |
| Description | Nicardipine is a racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. It has a role as an antihypertensive agent, a calcium channel blocker, a vasodilator agent and an autophagy inhibitor. It contains a (S)-nicardipine and a (R)-nicardipine. |
| Classification | Small molecule |
| Drug class | phenylpyridine vasodilators; tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1 |
Identifiers
| PDB | — |
| CAS-ID | 55985-32-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1484 |
| ChEBI ID | 7550 |
| PubChem CID | 4474 |
| DrugBank | DB00622 |
| UNII ID | CZ5312222S (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNA4
KCNA4
ADORA3
ADORA3
Organism
Homo sapiens
Gene name
KCNA4
Gene synonyms
KCNA4L
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily A member 4
Protein synonyms
cardiac potassium channel, fetal skeletal muscle potassium channel, HPCN2, potassium channel 2, potassium channel, voltage gated shaker related subfamily A, member 4, rapidly inactivating potassium channel, shaker-related potassium channel Kv1.4, type A potassium channel, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv1.4
Uniprot ID
Mouse ortholog
Kcna4 (16492)
potassium voltage-gated channel subfamily A member 4 (Q8CBF8)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Nicardipine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,954 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,003 adverse events reported
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