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Drug ReportsNiacin
Wampocap, Tredaptive(niacin)
Niacin, Niacor (niacin) is a small molecule pharmaceutical. Niacin was first approved as Wampocap on 1982-01-01. It is used to treat hypercholesterolemia, hypertriglyceridemia, pellagra, and peripheral vascular diseases in the USA. It is known to target hydroxycarboxylic acid receptor 1, hydroxycarboxylic acid receptor 2, and hydroxycarboxylic acid receptor 3.
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Variants
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Niacin, Niacor (discontinued: Niacin, Niaspan titration starter pack, Nicolar, Wampocap)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Niacin
Tradename
Company
Number
Date
Products
NIASPANAbbVieN-020381 DISCN1997-07-28
4 products, RLD
NIASPAN TITRATION STARTER PACKAbbVieN-020381 DISCN1997-07-28
1 products
WAMPOCAPMedpointe Pharm HlcN-011073 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
011010 niacinamide 4% / tretinoin 0.025%unapproved drug other2020-07-02
011013 niacinamide 4% / tretinoin 0.025%unapproved drug other2020-07-02
011020 niacinamide 4% / tretinoin 0.05%unapproved drug other2020-07-02
011021 niacinamide 4% / tretinoin 0.05%unapproved drug other2020-07-02
011054 niacinamide 4% / spironolactone 5%unapproved drug other2020-07-02
011218 niacinamide 2% / spironolactone 5% / tretinoin 0.025%unapproved drug other2020-07-02
011220 niacinamide 2% / spironolactone 5% / tretinoin 0.05%unapproved drug other2020-07-02
011312 niacinamide 4% / tazarotene 0.05%unapproved drug other2020-07-02
011503 dapsone 6% / niacinamide 2% / spironolactone 5%unapproved drug other2020-07-02
011504 dapsone 8.5% / niacinamide 4%unapproved drug other2020-07-02
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypercholesterolemia—D006937—
hypertriglyceridemiaEFO_0004211D015228—
peripheral vascular diseasesEFO_0003875D016491I73.9
pellagra—D010383—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C04: Peripheral vasodilators
— C04A: Peripheral vasodilators
— C04AC: Nicotinic acid and derivatives, peripheral vasodilators
— C04AC01: Nicotinic acid
— C10: Lipid modifying agents
— C10A: Lipid modifying agents, plain
— C10AD: Nicotinic acid and derivatives, lipid modifying, plain
— C10AD02: Nicotinic acid
— C10AD52: Nicotinic acid, combinations
— C10B: Lipid modifying agents, combinations
— C10BA: Combinations of various lipid modifying agents
— C10BA01: Lovastatin and nicotinic acid
HCPCS
No data
Clinical
Clinical Trials
1468 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277—C80.07415067942302
Hepatocellular carcinomaD006528—C22.066111591036243
Liver neoplasmsD008113EFO_1001513C22.071110471032232
NeoplasmsD009369—C80592671792
Renal cell carcinomaD002292EFO_0000376—17441612092
DyslipidemiasD050171——651314745
Healthy volunteers/patients———244—11443
HypercholesterolemiaD006937——42173632
Diabetes mellitusD003920EFO_0000400E08-E134783627
Type 2 diabetes mellitusD003924EFO_0001360E117763526
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C9521265—546
RecurrenceD012008——14322—246
Myeloid leukemia acuteD015470—C92.021193—440
Myeloid leukemiaD007951—C9216203—436
Lung neoplasmsD008175—C34.9011244——36
Non-small-cell lung carcinomaD002289——11195—132
Breast neoplasmsD001943EFO_0003869C509231—230
MelanomaD008545——10172——27
Thyroid diseasesD013959—E00-E07—183—221
Kidney neoplasmsD007680EFO_0003865C64783—320
Show 122 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SarcomaD012509——711———16
Prostatic neoplasmsD011471—C61610——115
Colorectal neoplasmsD015179——510——215
GlioblastomaD005909EFO_0000515—710——114
Myelodysplastic syndromesD009190—D4679———13
InflammationD007249MP_0001845—33——813
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.075———11
Brain neoplasmsD001932EFO_0003833C7185——111
LymphomaD008223—C85.984———10
Lymphoid leukemiaD007945—C9165———10
Show 228 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Metabolic diseasesD008659EFO_0000589E88.94———59
Hematologic neoplasmsD019337——3———14
PharmacokineticsD010599——3———14
Abdominal obesityD056128——1———23
Glucose intoleranceD018149HP_0000833R73.031———23
Prediabetic stateD011236EFO_1001121R73.031———23
Megakaryoblastic leukemia acuteD007947—C94.23————3
Myelomonocytic leukemia acuteD015479—C92.53————3
Basophilic leukemia acuteD015471—C94.83————3
Erythroblastic leukemia acuteD004915EFO_1001257C94.03————3
Show 65 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DermatitisD003872—L30.9————44
Healthy agingD000073656——————44
Diet therapyD004035——————33
ConstipationD003248—K59.0————33
Congenital heart defectsD006330—Q24.9————33
Respiratory tract infectionsD012141—J06.9————33
CognitionD003071EFO_0003925—————33
ExerciseD015444EFO_0000483—————33
OverweightD050177—E66.3————33
Heart valve diseasesD006349EFO_0009551I08————33
Show 130 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameNiacin
INNnicotinic acid
Description
Nicotinic acid is a pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group. It has a role as an antidote, an antilipemic drug, a vasodilator agent, a metabolite, an EC 3.5.1.19 (nicotinamidase) inhibitor, an Escherichia coli metabolite, a mouse metabolite, a human urinary metabolite and a plant metabolite. It is a vitamin B3, a pyridinemonocarboxylic acid and a pyridine alkaloid. It is a conjugate acid of a nicotinate.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C(O)c1cccnc1
Identifiers
PDB—
CAS-ID59-67-6
RxCUI—
ChEMBL IDCHEMBL573
ChEBI ID15940
PubChem CID938
DrugBankDB00627
UNII ID2679MF687A (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA2
CA2
Organism
Homo sapiens
Gene name
CA2
Gene synonyms
NCBI Gene ID
760
Protein name
carbonic anhydrase 2
Protein synonyms
CA-II, CAC, Carbonate dehydratase II, carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase II, carbonic dehydratase, Cyanamide hydratase CA2, epididymis luminal protein 76, epididymis secretory protein Li 282
Uniprot ID
Q96ET9
Mouse ortholog
Car2 (12349)
carbonic anhydrase 2 (Q9DCY9)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Niaspan – AbbVie
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Estimated US medical usage
Niacin
+
Lovastatin
Total medical expenditures per year (USD, in millions)
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Niacin
Total medical expenditures per year (USD, in millions)
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Niacin
+
Simvastatin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19,839 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal 90 dha, Citranatal assure, Citranatal dha, Citranatal essence, Citranatal rx, Healthy mamabe well rounded, Marnatal f, Moms choice rx, Natafort, Nestabs, Nestabs dha, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate elite, Select ob, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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48,671 adverse events reported
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